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Illumina Body Map 2: averaged replicates
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Results for OLIG2_NEUROD1_ATOH1
Z-value: 1.73
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Transcription factors associated with OLIG2_NEUROD1_ATOH1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000205927.4 | oligodendrocyte transcription factor 2 | |
| ENSG00000162992.3 | neuronal differentiation 1 | |
| ENSG00000172238.3 | atonal bHLH transcription factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATOH1 | hg19_v2_chr4_+_94750014_94750042 | 0.29 | 1.1e-01 | Click! |
| OLIG2 | hg19_v2_chr21_+_34398153_34398250 | 0.25 | 1.6e-01 | Click! |
| NEUROD1 | hg19_v2_chr2_-_182545603_182545603 | -0.20 | 2.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_195310802 Show fit | 7.73 |
ENST00000421243.1
ENST00000453131.1 |
apolipoprotein D |
|
| chr4_+_114214125 Show fit | 4.23 |
ENST00000509550.1
|
ankyrin 2, neuronal |
|
| chr15_-_94614049 Show fit | 4.08 |
ENST00000556447.1
ENST00000555772.1 |
CTD-3049M7.1 |
|
| chr19_-_45826125 Show fit | 3.70 |
ENST00000221476.3
|
creatine kinase, muscle |
|
| chr5_+_71475449 Show fit | 3.55 |
ENST00000504492.1
|
microtubule-associated protein 1B |
|
| chr6_+_53948328 Show fit | 3.43 |
ENST00000370876.2
|
muscular LMNA-interacting protein |
|
| chr1_-_171621815 Show fit | 3.40 |
ENST00000037502.6
|
myocilin, trabecular meshwork inducible glucocorticoid response |
|
| chr19_-_49944806 Show fit | 3.17 |
ENST00000221485.3
|
solute carrier family 17 (vesicular glutamate transporter), member 7 |
|
| chr2_-_152590946 Show fit | 3.04 |
ENST00000172853.10
|
nebulin |
|
| chr6_+_53948221 Show fit | 2.68 |
ENST00000460844.2
|
muscular LMNA-interacting protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of OLIG2_NEUROD1_ATOH1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.3 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 2.0 | 8.0 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.0 | 7.4 | GO:0006936 | muscle contraction(GO:0006936) |
| 1.4 | 6.8 | GO:0036371 | protein localization to T-tubule(GO:0036371) |
| 0.4 | 6.5 | GO:0014722 | regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722) |
| 0.1 | 5.3 | GO:1901016 | regulation of potassium ion transmembrane transporter activity(GO:1901016) |
| 0.0 | 3.7 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.6 | 3.6 | GO:0018032 | protein amidation(GO:0018032) |
| 0.9 | 3.4 | GO:0014734 | skeletal muscle hypertrophy(GO:0014734) |
| 0.4 | 3.4 | GO:0008582 | regulation of synaptic growth at neuromuscular junction(GO:0008582) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.8 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 11.9 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 9.0 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 8.4 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.1 | 6.6 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 6.5 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 5.8 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.0 | 4.6 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.1 | 4.5 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.4 | 4.4 | GO:0060199 | clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.2 | 10.9 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 9.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.1 | 7.7 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 6.8 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 6.2 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 6.1 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 5.2 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.4 | 3.7 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 3.7 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.8 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 3.1 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 2.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 2.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.4 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 2.2 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 1.8 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 1.8 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.7 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 7.4 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 6.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 5.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 4.6 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 4.4 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 3.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 3.5 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 3.0 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 2.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |