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Illumina Body Map 2: averaged replicates
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Results for OLIG3_NEUROD2_NEUROG2
Z-value: 2.27
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Transcription factors associated with OLIG3_NEUROD2_NEUROG2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000177468.5 | oligodendrocyte transcription factor 3 | |
| ENSG00000171532.4 | neuronal differentiation 2 | |
| ENSG00000178403.3 | neurogenin 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NEUROD2 | hg19_v2_chr17_-_37764128_37764258 | 0.58 | 5.5e-04 | Click! |
| NEUROG2 | hg19_v2_chr4_-_113437328_113437337 | 0.24 | 1.8e-01 | Click! |
| OLIG3 | hg19_v2_chr6_-_137815524_137815537 | 0.01 | 9.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_35649365 Show fit | 9.09 |
ENST00000437887.1
|
Uncharacterized protein |
|
| chr14_-_23904861 Show fit | 8.11 |
ENST00000355349.3
|
myosin, heavy chain 7, cardiac muscle, beta |
|
| chr2_-_166930131 Show fit | 7.91 |
ENST00000303395.4
ENST00000409050.1 ENST00000423058.2 ENST00000375405.3 |
sodium channel, voltage-gated, type I, alpha subunit |
|
| chr9_-_130635741 Show fit | 6.85 |
ENST00000223836.10
|
adenylate kinase 1 |
|
| chr3_-_195310802 Show fit | 6.77 |
ENST00000421243.1
ENST00000453131.1 |
apolipoprotein D |
|
| chr2_-_152382500 Show fit | 6.42 |
ENST00000434685.1
|
nebulin |
|
| chr6_+_53948221 Show fit | 5.88 |
ENST00000460844.2
|
muscular LMNA-interacting protein |
|
| chr1_-_144994909 Show fit | 5.54 |
ENST00000369347.4
ENST00000369354.3 |
phosphodiesterase 4D interacting protein |
|
| chr4_-_100575781 Show fit | 5.50 |
ENST00000511828.1
|
Protein LOC285556 |
|
| chr6_-_33714667 Show fit | 5.34 |
ENST00000293756.4
|
inositol hexakisphosphate kinase 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of OLIG3_NEUROD2_NEUROG2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 18.1 | GO:0014724 | regulation of twitch skeletal muscle contraction(GO:0014724) |
| 0.0 | 9.8 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.6 | 9.1 | GO:0098870 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.6 | 9.0 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.8 | 8.8 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.2 | 8.2 | GO:0032958 | inositol phosphate biosynthetic process(GO:0032958) |
| 0.4 | 7.7 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 7.6 | GO:0097120 | receptor localization to synapse(GO:0097120) |
| 0.1 | 7.0 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 1.7 | 6.8 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 31.8 | GO:0030016 | myofibril(GO:0030016) |
| 0.1 | 14.4 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 13.0 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.4 | 11.1 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.0 | 9.4 | GO:0030426 | growth cone(GO:0030426) |
| 0.4 | 9.3 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.6 | 9.0 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.3 | 8.2 | GO:0032982 | myosin filament(GO:0032982) |
| 0.6 | 7.7 | GO:0060199 | clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203) |
| 0.2 | 6.4 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.1 | GO:0008017 | microtubule binding(GO:0008017) |
| 2.0 | 9.8 | GO:0052839 | inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839) |
| 0.3 | 9.8 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 9.8 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.3 | 9.3 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.1 | 8.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.3 | 8.1 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 1.1 | 7.7 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.1 | 7.5 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.1 | 7.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 5.8 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.1 | 5.6 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 4.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.2 | 4.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 4.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 3.5 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 3.3 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 3.0 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 2.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.3 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 9.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 9.2 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.4 | 8.1 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.0 | 7.6 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 7.3 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.2 | 7.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 6.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 6.1 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 6.1 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |