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Illumina Body Map 2: averaged replicates
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Results for ONECUT1
Z-value: 3.34
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Transcription factors associated with ONECUT1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ONECUT1 | hg19_v2_chr15_-_53082178_53082209 | 0.45 | 1.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_57320437 Show fit | 18.62 |
ENST00000361249.3
|
complement component 8, alpha polypeptide |
|
| chr1_-_159684371 Show fit | 17.73 |
ENST00000255030.5
ENST00000437342.1 ENST00000368112.1 ENST00000368111.1 ENST00000368110.1 ENST00000343919.2 |
C-reactive protein, pentraxin-related |
|
| chr12_+_111471828 Show fit | 17.22 |
ENST00000261726.6
|
cut-like homeobox 2 |
|
| chr1_+_159557607 Show fit | 17.11 |
ENST00000255040.2
|
amyloid P component, serum |
|
| chr13_-_46679144 Show fit | 15.96 |
ENST00000181383.4
|
carboxypeptidase B2 (plasma) |
|
| chr9_-_116840728 Show fit | 15.41 |
ENST00000265132.3
|
alpha-1-microglobulin/bikunin precursor |
|
| chr3_-_170744498 Show fit | 15.00 |
ENST00000382808.4
ENST00000314251.3 |
solute carrier family 2 (facilitated glucose transporter), member 2 |
|
| chr13_-_46679185 Show fit | 14.52 |
ENST00000439329.3
|
carboxypeptidase B2 (plasma) |
|
| chr17_-_26697304 Show fit | 13.88 |
ENST00000536498.1
|
vitronectin |
|
| chr3_+_186383741 Show fit | 13.70 |
ENST00000232003.4
|
histidine-rich glycoprotein |
Network of associatons between targets according to the STRING database.
First level regulatory network of ONECUT1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.6 | 30.5 | GO:0003330 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 5.5 | 27.7 | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902) positive regulation of phospholipid catabolic process(GO:0060697) |
| 2.6 | 26.5 | GO:0045959 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) |
| 0.8 | 18.6 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 1.0 | 17.7 | GO:0032930 | positive regulation of superoxide anion generation(GO:0032930) |
| 0.7 | 17.2 | GO:0007614 | short-term memory(GO:0007614) |
| 2.4 | 17.1 | GO:0052199 | negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) |
| 0.1 | 16.9 | GO:0046849 | bone remodeling(GO:0046849) |
| 1.0 | 15.4 | GO:0046149 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 3.0 | 15.2 | GO:0034224 | cellular response to zinc ion starvation(GO:0034224) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 62.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 51.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 3.1 | 27.7 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.0 | 26.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 1.5 | 26.6 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.2 | 26.5 | GO:0044217 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 1.9 | 18.6 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 16.8 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 16.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 3.5 | 13.9 | GO:0071062 | rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 36.6 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 3.5 | 34.8 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.7 | 30.5 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 28.9 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) |
| 0.1 | 19.3 | GO:0005539 | glycosaminoglycan binding(GO:0005539) |
| 0.6 | 18.6 | GO:0001848 | complement binding(GO:0001848) |
| 0.1 | 17.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.5 | 16.2 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 3.9 | 15.4 | GO:0019862 | IgA binding(GO:0019862) |
| 0.3 | 15.2 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 71.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 45.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 27.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 14.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 7.4 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 7.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 5.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 2.5 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 2.2 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 2.2 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 45.1 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 1.0 | 27.7 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.6 | 25.1 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 1.3 | 17.7 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.7 | 15.6 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.4 | 15.2 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 15.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 12.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 12.3 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.3 | 12.0 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |