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Illumina Body Map 2: averaged replicates
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Results for ONECUT2_ONECUT3
Z-value: 1.61
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Transcription factors associated with ONECUT2_ONECUT3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ONECUT2 | hg19_v2_chr18_+_55102917_55102985 | 0.22 | 2.4e-01 | Click! |
| ONECUT3 | hg19_v2_chr19_+_1752372_1752372 | 0.18 | 3.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_63428752 Show fit | 7.28 |
ENST00000295894.5
|
synaptoporin |
|
| chr14_-_24047965 Show fit | 5.51 |
ENST00000397118.3
ENST00000356300.4 |
junctophilin 4 |
|
| chr10_+_95517616 Show fit | 4.43 |
ENST00000371418.4
|
leucine-rich, glioma inactivated 1 |
|
| chr10_+_95517660 Show fit | 4.28 |
ENST00000371413.3
|
leucine-rich, glioma inactivated 1 |
|
| chr10_+_95517566 Show fit | 4.00 |
ENST00000542308.1
|
leucine-rich, glioma inactivated 1 |
|
| chr12_-_62586543 Show fit | 3.53 |
ENST00000416284.3
|
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 |
|
| chr11_+_134144139 Show fit | 3.50 |
ENST00000389887.5
|
galactosidase, beta 1-like 3 |
|
| chr8_+_77316233 Show fit | 3.39 |
ENST00000603284.1
ENST00000603837.1 |
RP11-706J10.2 long intergenic non-protein coding RNA 1109 |
|
| chr2_-_192016316 Show fit | 3.27 |
ENST00000358470.4
ENST00000432798.1 ENST00000450994.1 |
signal transducer and activator of transcription 4 |
|
| chr3_-_187388173 Show fit | 3.23 |
ENST00000287641.3
|
somatostatin |
Network of associatons between targets according to the STRING database.
First level regulatory network of ONECUT2_ONECUT3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.7 | GO:0050806 | positive regulation of synaptic transmission(GO:0050806) |
| 1.4 | 6.9 | GO:2000471 | regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473) |
| 0.4 | 5.5 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.0 | 5.2 | GO:0035722 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 0.1 | 4.5 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.1 | 4.3 | GO:0044705 | mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705) |
| 0.4 | 4.0 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.6 | 3.2 | GO:0008628 | hormone-mediated apoptotic signaling pathway(GO:0008628) |
| 0.2 | 3.2 | GO:0098870 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.6 | 2.5 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.0 | GO:0045202 | synapse(GO:0045202) |
| 0.3 | 10.0 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.4 | 5.5 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.1 | 4.6 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 4.1 | GO:0043679 | axon terminus(GO:0043679) |
| 0.1 | 3.9 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.2 | 2.5 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 2.5 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 1.8 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 1.7 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.9 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 4.1 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.4 | 4.0 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 3.7 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.3 | 3.5 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.1 | 3.2 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.2 | 2.5 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.0 | 2.5 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.3 | 2.4 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.0 | 2.4 | GO:0005179 | hormone activity(GO:0005179) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 8.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 7.6 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 1.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 0.7 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.6 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 0.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.5 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.9 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.1 | 5.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 4.0 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 3.5 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 3.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 2.5 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 2.4 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.0 | 1.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 1.6 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 1.4 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |