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Illumina Body Map 2: averaged replicates

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Results for OVOL1

Z-value: 0.48

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Transcription factors associated with OVOL1

Gene Symbol Gene ID Gene Info
OVOL1
ENSG00000172818.5 ovo like transcriptional repressor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
OVOL1hg19_v2_chr11_+_65554493_65554546-0.134.7e-01Click!

Activity profile of OVOL1 motif

Sorted Z-values of OVOL1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_73848764 1.22 ENST00000317376.4
ENST00000412663.1
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr10_-_73848531 1.14 ENST00000373109.2
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr10_-_73848086 1.10 ENST00000536168.1
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr5_+_161277603 0.81 ENST00000519621.1
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr7_-_38389573 0.77 ENST00000390344.2
TRGV5
T cell receptor gamma variable 5
chr6_-_84419101 0.66 ENST00000520302.1
ENST00000520213.1
ENST00000439399.2
ENST00000428679.2
ENST00000437520.1
SNAP91
synaptosomal-associated protein, 91kDa
chr5_+_140261703 0.49 ENST00000409494.1
ENST00000289272.2
PCDHA13
protocadherin alpha 13
chr1_+_174846570 0.36 ENST00000392064.2
RABGAP1L
RAB GTPase activating protein 1-like
chr2_-_183387283 0.35 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr19_-_52005009 0.30 ENST00000291707.3
SIGLEC12
sialic acid binding Ig-like lectin 12 (gene/pseudogene)
chr15_-_64385981 0.28 ENST00000557835.1
ENST00000380290.3
ENST00000559950.1
FAM96A
family with sequence similarity 96, member A
chr15_-_64386120 0.26 ENST00000300030.3
FAM96A
family with sequence similarity 96, member A
chr9_+_125562370 0.26 ENST00000277309.2
OR1K1
olfactory receptor, family 1, subfamily K, member 1
chr4_-_68620053 0.24 ENST00000420975.2
ENST00000226413.4
GNRHR
gonadotropin-releasing hormone receptor
chr11_+_71710973 0.23 ENST00000393707.4
IL18BP
interleukin 18 binding protein
chr10_-_21786179 0.22 ENST00000377113.5
CASC10
cancer susceptibility candidate 10
chr11_-_75017734 0.18 ENST00000532525.1
ARRB1
arrestin, beta 1
chr19_+_6772710 0.18 ENST00000304076.2
ENST00000602142.1
ENST00000596764.1
VAV1
vav 1 guanine nucleotide exchange factor
chr3_-_165555200 0.18 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
BCHE
butyrylcholinesterase
chr2_-_183387430 0.15 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr16_-_67260691 0.14 ENST00000447579.1
ENST00000393992.1
ENST00000424285.1
LRRC29
leucine rich repeat containing 29
chr2_-_183387064 0.14 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr16_-_67260901 0.14 ENST00000341546.3
ENST00000409509.1
ENST00000433915.1
ENST00000454102.2
LRRC29
AC040160.1
leucine rich repeat containing 29
Uncharacterized protein; cDNA FLJ57407, weakly similar to Mus musculus leucine rich repeat containing 29 (Lrrc29), mRNA
chr5_+_140739537 0.12 ENST00000522605.1
PCDHGB2
protocadherin gamma subfamily B, 2
chr15_+_64386261 0.08 ENST00000560829.1
SNX1
sorting nexin 1
chr14_+_29241910 0.08 ENST00000399387.4
ENST00000552957.1
ENST00000548213.1
C14orf23
chromosome 14 open reading frame 23
chrX_-_117107680 0.07 ENST00000447671.2
ENST00000262820.3
KLHL13
kelch-like family member 13
chr4_+_76481258 0.07 ENST00000311623.4
ENST00000435974.2
C4orf26
chromosome 4 open reading frame 26
chr1_-_98515395 0.07 ENST00000424528.2
MIR137HG
MIR137 host gene (non-protein coding)
chr5_-_16509101 0.04 ENST00000399793.2
FAM134B
family with sequence similarity 134, member B
chr20_+_54823788 0.04 ENST00000243911.2
MC3R
melanocortin 3 receptor
chr5_+_67535647 0.02 ENST00000520675.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr15_+_75335604 0.01 ENST00000563393.1
PPCDC
phosphopantothenoylcysteine decarboxylase

Network of associatons between targets according to the STRING database.

First level regulatory network of OVOL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.2 GO:0014016 neuroblast differentiation(GO:0014016)
0.0 0.8 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.2 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.2 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.6 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.8 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.2 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.1 0.2 GO:0042007 interleukin-18 binding(GO:0042007)
0.1 0.2 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.0 0.2 GO:0033265 acetylcholinesterase activity(GO:0003990) choline binding(GO:0033265)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.7 GO:0005545 1-phosphatidylinositol binding(GO:0005545)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.5 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects