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Illumina Body Map 2: averaged replicates
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Results for PATZ1_KLF4
Z-value: 3.62
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Transcription factors associated with PATZ1_KLF4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF4 | hg19_v2_chr9_-_110251836_110251927 | 0.63 | 1.1e-04 | Click! |
| PATZ1 | hg19_v2_chr22_-_31741757_31741770 | 0.06 | 7.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_22457100 Show fit | 13.59 |
ENST00000409586.3
|
chromosome 8 open reading frame 58 |
|
| chr18_+_77155856 Show fit | 11.50 |
ENST00000253506.5
ENST00000591814.1 |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 |
|
| chr8_+_22457127 Show fit | 11.27 |
ENST00000289989.5
|
chromosome 8 open reading frame 58 |
|
| chr18_+_77155942 Show fit | 11.00 |
ENST00000397790.2
|
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 |
|
| chr2_-_37899323 Show fit | 10.55 |
ENST00000295324.3
ENST00000457889.1 |
CDC42 effector protein (Rho GTPase binding) 3 |
|
| chr19_-_39226045 Show fit | 10.37 |
ENST00000597987.1
ENST00000595177.1 |
calpain 12 |
|
| chr4_+_154387480 Show fit | 10.18 |
ENST00000409663.3
ENST00000440693.1 ENST00000409959.3 |
KIAA0922 |
|
| chr11_-_64512469 Show fit | 9.45 |
ENST00000377485.1
|
RAS guanyl releasing protein 2 (calcium and DAG-regulated) |
|
| chr6_-_30654977 Show fit | 9.16 |
ENST00000399199.3
|
protein phosphatase 1, regulatory subunit 18 |
|
| chr20_+_42295745 Show fit | 8.97 |
ENST00000396863.4
ENST00000217026.4 |
v-myb avian myeloblastosis viral oncogene homolog-like 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PATZ1_KLF4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 254.2 | GO:0042119 | neutrophil activation(GO:0042119) |
| 0.1 | 72.8 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter(GO:0000122) |
| 0.5 | 70.4 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.6 | 63.8 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 0.3 | 57.6 | GO:0038096 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.5 | 57.1 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.3 | 40.0 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.2 | 39.5 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 0.6 | 38.3 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.4 | 37.8 | GO:0042795 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 475.0 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.5 | 218.6 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.3 | 206.5 | GO:0016604 | nuclear body(GO:0016604) |
| 0.2 | 127.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.7 | 115.7 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.6 | 99.8 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 91.3 | GO:0005634 | nucleus(GO:0005634) |
| 0.7 | 90.4 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.5 | 89.1 | GO:0016605 | PML body(GO:0016605) |
| 0.7 | 74.9 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 158.1 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 116.4 | GO:0003677 | DNA binding(GO:0003677) |
| 0.6 | 111.6 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 92.3 | GO:0001012 | RNA polymerase II regulatory region DNA binding(GO:0001012) |
| 0.6 | 82.1 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.6 | 81.2 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.3 | 77.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 75.9 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.3 | 70.9 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.3 | 62.3 | GO:0042393 | histone binding(GO:0042393) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 143.6 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.7 | 113.9 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.6 | 92.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 1.1 | 87.2 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.4 | 67.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.9 | 66.5 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 1.1 | 66.0 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 1.0 | 61.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.7 | 59.7 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.6 | 59.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 83.5 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.2 | 76.3 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.2 | 61.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.1 | 59.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.4 | 55.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.9 | 46.5 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.7 | 46.1 | REACTOME IL 3 5 AND GM CSF SIGNALING | Genes involved in Interleukin-3, 5 and GM-CSF signaling |
| 0.3 | 44.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.1 | 44.2 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.5 | 43.5 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |