ISMARA results: PAX5

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Illumina Body Map 2: averaged replicates

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Results for PAX5

Z-value: 2.63

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Transcription factors associated with PAX5

Gene Symbol	Gene ID	Gene Info
PAX5 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000196092.8	paired box 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PAX5	hg19_v2_chr9_-_37034028_37034157	0.81	2.5e-08	Click!

Activity profile of PAX5 motif

Sorted Z-values of PAX5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_+_23101182 Show fit	5.18	ENST00000390312.2	IGLV2-14 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 2-14
chr2_+_89986318 Show fit	5.00	ENST00000491977.1	IGKV2D-29 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 2D-29
chr14_-_107170409 Show fit	4.81	ENST00000390633.2	IGHV1-69 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy variable 1-69
chr14_-_106539557 Show fit	4.80	ENST00000390599.2	IGHV1-8 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy variable 1-8
chr22_+_23165153 Show fit	4.73	ENST00000390317.2	IGLV2-8 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 2-8
chr22_+_22930626 Show fit	4.72	ENST00000390302.2	IGLV2-33 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 2-33 (non-functional)
chr22_+_23040274 Show fit	4.42	ENST00000390306.2	IGLV2-23 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 2-23
chr22_+_22385332 Show fit	4.08	ENST00000390282.2	IGLV4-69 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 4-69
chr22_-_37882395 Show fit	4.07	ENST00000416983.3 ENST00000424765.2 ENST00000356998.3	MFNG Ensembl NCBI GeneCards UniProt NextProt Show fit	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr14_-_106069247 Show fit	3.89	ENST00000479229.1	RP11-731F5.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-731F5.1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	139.1	GO:0006958	complement activation, classical pathway(GO:0006958)
0.4	85.3	GO:0002377	immunoglobulin production(GO:0002377)
0.1	36.3	GO:0002250	adaptive immune response(GO:0002250)
0.0	32.0	GO:0043312	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.2	16.3	GO:0006968	cellular defense response(GO:0006968)
0.5	13.6	GO:0072540	T-helper 17 cell lineage commitment(GO:0072540)
0.6	12.9	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.3	12.2	GO:0007202	activation of phospholipase C activity(GO:0007202)
0.1	12.1	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.1	10.4	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)

Showing 1 to 10 of 910 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	52.8	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.1	47.1	GO:0009897	external side of plasma membrane(GO:0009897)
0.1	20.6	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	20.3	GO:0005615	extracellular space(GO:0005615)
0.0	18.7	GO:0000790	nuclear chromatin(GO:0000790)
0.5	17.6	GO:0042101	T cell receptor complex(GO:0042101)
0.3	17.6	GO:0001772	immunological synapse(GO:0001772)
0.2	17.4	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.1	15.4	GO:0072562	blood microparticle(GO:0072562)
0.4	15.0	GO:0001891	phagocytic cup(GO:0001891)

Showing 1 to 10 of 300 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	174.4	GO:0003823	antigen binding(GO:0003823)
0.9	61.0	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.2	21.7	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	19.8	GO:0005096	GTPase activator activity(GO:0005096)
0.4	13.0	GO:0042288	MHC class I protein binding(GO:0042288)
1.1	9.9	GO:0042610	CD8 receptor binding(GO:0042610)
0.2	9.8	GO:0042169	SH2 domain binding(GO:0042169)
0.0	8.9	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.5	6.8	GO:0019864	IgG binding(GO:0019864)
0.7	6.6	GO:0019863	IgE binding(GO:0019863)

Showing 1 to 10 of 571 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	29.8	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.3	27.3	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.2	20.6	PID IL4 2PATHWAY	IL4-mediated signaling events
0.2	11.1	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.3	10.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2	10.4	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	9.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	9.1	PID BCR 5PATHWAY	BCR signaling pathway
0.1	8.6	PID CMYB PATHWAY	C-MYB transcription factor network
0.2	7.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling

Showing 1 to 10 of 97 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	36.0	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3	21.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.3	17.5	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.6	15.6	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	11.4	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.3	9.5	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	8.1	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2	6.1	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.2	5.8	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.1	5.5	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA

Showing 1 to 10 of 157 entries

Results for PAX5

Z-value: 2.63

Motif logo

Transcription factors associated with PAX5

Activity-expression correlation:

Activity profile of PAX5 motif

Sorted Z-values of PAX5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: