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Illumina Body Map 2: averaged replicates
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Results for PBX3
Z-value: 2.95
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Transcription factors associated with PBX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PBX3 | hg19_v2_chr9_+_128510454_128510478 | 0.35 | 4.8e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PBX3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 20.2 | GO:0035995 | detection of muscle stretch(GO:0035995) |
| 0.1 | 16.3 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.6 | 12.8 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 4.0 | 12.0 | GO:0031448 | regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) |
| 0.1 | 10.2 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 0.2 | 9.2 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.0 | 7.9 | GO:0051149 | positive regulation of muscle cell differentiation(GO:0051149) |
| 0.2 | 7.7 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.3 | 6.4 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
| 0.3 | 6.3 | GO:0045199 | maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 16.2 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.4 | 12.0 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.0 | 11.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.5 | 9.9 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.1 | 8.1 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.2 | 7.5 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 7.4 | GO:0036379 | myofilament(GO:0036379) |
| 0.0 | 7.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.9 | 7.1 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.2 | 6.5 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.1 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 1.0 | 15.0 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.3 | 11.9 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 1.7 | 11.6 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.1 | 9.3 | GO:0001618 | virus receptor activity(GO:0001618) |
| 1.0 | 7.0 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
| 1.7 | 6.8 | GO:0048763 | calcium-induced calcium release activity(GO:0048763) |
| 0.2 | 6.7 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 6.5 | GO:0003678 | DNA helicase activity(GO:0003678) |
| 0.1 | 6.4 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.7 | PID FGF PATHWAY | FGF signaling pathway |
| 0.2 | 9.6 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.2 | 6.4 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 5.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 3.4 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 2.9 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 2.8 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 2.4 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 2.4 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 2.0 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.4 | 11.6 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 10.7 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.2 | 9.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 9.8 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 9.5 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 9.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 8.6 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 7.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 7.0 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |