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Illumina Body Map 2: averaged replicates
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Results for PITX1
Z-value: 2.50
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Transcription factors associated with PITX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX1 | hg19_v2_chr5_-_134369973_134369988 | -0.04 | 8.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_161035655 Show fit | 10.09 |
ENST00000600454.1
|
Uncharacterized protein |
|
| chr5_-_55224569 Show fit | 8.37 |
ENST00000595799.1
|
Uncharacterized protein |
|
| chr12_-_66317967 Show fit | 8.08 |
ENST00000601398.1
|
Uncharacterized protein |
|
| chr19_-_2256405 Show fit | 6.80 |
ENST00000300961.6
|
junctional sarcoplasmic reticulum protein 1 |
|
| chr22_-_24096562 Show fit | 6.72 |
ENST00000398465.3
|
pre-B lymphocyte 3 |
|
| chr22_-_24096630 Show fit | 6.60 |
ENST00000248948.3
|
pre-B lymphocyte 3 |
|
| chr11_-_118213455 Show fit | 6.49 |
ENST00000300692.4
|
CD3d molecule, delta (CD3-TCR complex) |
|
| chr7_+_73623717 Show fit | 6.05 |
ENST00000344995.5
ENST00000460943.1 |
linker for activation of T cells family, member 2 |
|
| chr16_+_30386098 Show fit | 5.72 |
ENST00000322861.7
|
myosin light chain, phosphorylatable, fast skeletal muscle |
|
| chr11_-_118213331 Show fit | 5.63 |
ENST00000392884.2
|
CD3d molecule, delta (CD3-TCR complex) |
Network of associatons between targets according to the STRING database.
First level regulatory network of PITX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.2 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.4 | 17.5 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.1 | 17.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 1.1 | 17.1 | GO:0045059 | positive thymic T cell selection(GO:0045059) |
| 0.6 | 16.1 | GO:0072540 | T-helper 17 cell lineage commitment(GO:0072540) |
| 0.1 | 15.9 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.6 | 11.0 | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291) |
| 0.6 | 10.6 | GO:0043383 | negative T cell selection(GO:0043383) |
| 0.3 | 9.1 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.1 | 6.3 | GO:0002260 | lymphocyte homeostasis(GO:0002260) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.8 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 1.4 | 18.8 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.1 | 18.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.4 | 16.5 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.5 | 15.7 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.2 | 15.5 | GO:0001772 | immunological synapse(GO:0001772) |
| 1.1 | 12.0 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 0.1 | 10.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 10.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 8.5 | GO:0005859 | muscle myosin complex(GO:0005859) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.0 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.0 | 16.8 | GO:0005525 | GTP binding(GO:0005525) |
| 1.4 | 16.3 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.2 | 16.3 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 13.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.0 | 12.0 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.1 | 11.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 10.8 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.1 | 10.0 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 7.7 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 22.2 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 13.7 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.2 | 12.9 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.2 | 12.6 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 11.7 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.2 | 10.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 8.1 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.1 | 8.1 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 7.4 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 7.2 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 17.4 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 16.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 14.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 11.7 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.2 | 11.5 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.1 | 10.6 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 8.4 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 7.4 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.4 | 6.5 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.1 | 6.5 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |