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Illumina Body Map 2: averaged replicates
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Results for PLAGL1
Z-value: 3.57
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Transcription factors associated with PLAGL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PLAGL1 | hg19_v2_chr6_-_144329531_144329546 | 0.67 | 2.5e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PLAGL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 67.6 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.2 | 35.0 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.2 | 27.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.2 | 26.5 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 15.9 | GO:0030198 | extracellular matrix organization(GO:0030198) |
| 0.6 | 15.5 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.1 | 14.5 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 2.0 | 12.3 | GO:0061364 | apoptotic process involved in luteolysis(GO:0061364) |
| 0.0 | 12.2 | GO:0007283 | spermatogenesis(GO:0007283) |
| 2.0 | 12.1 | GO:0030421 | defecation(GO:0030421) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 84.1 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.2 | 62.5 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 40.4 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 37.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 30.1 | GO:0030055 | cell-substrate junction(GO:0030055) |
| 0.2 | 29.1 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 23.4 | GO:0016604 | nuclear body(GO:0016604) |
| 0.2 | 23.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 20.3 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.2 | 19.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 102.5 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.4 | 78.3 | GO:0003823 | antigen binding(GO:0003823) |
| 1.1 | 69.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 28.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 21.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 19.4 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.1 | 19.2 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 16.0 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.2 | 15.4 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 15.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 99.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 40.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 38.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 30.1 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 25.3 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.3 | 20.5 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.3 | 19.2 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 19.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 19.1 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 17.6 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 33.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.3 | 23.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 19.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.4 | 17.6 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.2 | 17.4 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 16.4 | REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK | Genes involved in Gastrin-CREB signalling pathway via PKC and MAPK |
| 0.1 | 15.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 14.8 | REACTOME CHROMOSOME MAINTENANCE | Genes involved in Chromosome Maintenance |
| 0.4 | 14.6 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.2 | 13.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |