ISMARA results: POU1F1

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Illumina Body Map 2: averaged replicates

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Results for POU1F1

Z-value: 2.16

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Transcription factors associated with POU1F1

Gene Symbol	Gene ID	Gene Info
POU1F1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000064835.6	POU class 1 homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
POU1F1	hg19_v2_chr3_-_87325612_87325654	0.41	1.9e-02	Click!

Activity profile of POU1F1 motif

Sorted Z-values of POU1F1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_+_101417919 Show fit	3.62	ENST00000561338.1	ALDH1A3 Ensembl NCBI GeneCards UniProt NextProt Show fit	aldehyde dehydrogenase 1 family, member A3
chr12_+_78359999 Show fit	3.60	ENST00000550503.1	NAV3 Ensembl NCBI GeneCards UniProt NextProt Show fit	neuron navigator 3
chr21_-_43735628 Show fit	3.54	ENST00000291525.10 ENST00000518498.1	TFF3 Ensembl NCBI GeneCards UniProt NextProt Show fit	trefoil factor 3 (intestinal)
chr21_-_15583165 Show fit	3.37	ENST00000536861.1	LIPI Ensembl NCBI GeneCards UniProt NextProt Show fit	lipase, member I
chr12_+_26164645 Show fit	3.29	ENST00000542004.1	RASSF8 Ensembl NCBI GeneCards UniProt NextProt Show fit	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr14_+_101295638 Show fit	3.28	ENST00000523671.2	MEG3 Ensembl NCBI GeneCards UniProt NextProt Show fit	maternally expressed 3 (non-protein coding)
chr1_+_77333117 Show fit	3.28	ENST00000477717.1	ST6GALNAC5 Ensembl NCBI GeneCards UniProt NextProt Show fit	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr15_-_56757329 Show fit	3.23	ENST00000260453.3	MNS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	meiosis-specific nuclear structural 1
chr4_-_118006697 Show fit	3.14	ENST00000310754.4	TRAM1L1 Ensembl NCBI GeneCards UniProt NextProt Show fit	translocation associated membrane protein 1-like 1
chr10_-_13043697 Show fit	3.05	ENST00000378825.3	CCDC3 Ensembl NCBI GeneCards UniProt NextProt Show fit	coiled-coil domain containing 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of POU1F1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.6	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2	6.9	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	6.1	GO:0006936	muscle contraction(GO:0006936)
0.0	5.9	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1	5.6	GO:0032233	positive regulation of actin filament bundle assembly(GO:0032233)
0.3	5.0	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0	4.6	GO:1902476	chloride transmembrane transport(GO:1902476)
0.1	4.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.2	4.0	GO:0070986	left/right axis specification(GO:0070986)
0.9	3.6	GO:0060166	olfactory pit development(GO:0060166)

Showing 1 to 10 of 139 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	14.4	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	9.6	GO:0030018	Z disc(GO:0030018)
0.1	8.9	GO:1904724	tertiary granule lumen(GO:1904724)
0.0	6.1	GO:0000790	nuclear chromatin(GO:0000790)
0.1	4.4	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	3.9	GO:0097014	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0	3.7	GO:0005796	Golgi lumen(GO:0005796)
0.1	3.4	GO:0005640	nuclear outer membrane(GO:0005640)
0.2	3.1	GO:0031209	SCAR complex(GO:0031209)
0.3	3.0	GO:0005610	laminin-5 complex(GO:0005610)

Showing 1 to 10 of 64 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	17.5	GO:0005509	calcium ion binding(GO:0005509)
0.0	7.0	GO:0004984	olfactory receptor activity(GO:0004984)
0.2	6.5	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	4.9	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.5	4.5	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	4.3	GO:0002162	dystroglycan binding(GO:0002162)
0.1	3.8	GO:0070412	R-SMAD binding(GO:0070412)
0.4	3.7	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2	3.7	GO:0070324	thyroid hormone binding(GO:0070324)
0.9	3.6	GO:0047273	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)

Showing 1 to 10 of 103 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.1	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	3.0	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	2.7	PID BMP PATHWAY	BMP receptor signaling
0.0	2.5	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.0	2.4	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	2.4	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	2.2	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	1.9	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	1.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	1.6	PID RHOA REG PATHWAY	Regulation of RhoA activity

Showing 1 to 10 of 26 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.8	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.1	4.2	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.1	3.7	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.1	3.4	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.1	3.2	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.1	3.1	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	3.0	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.1	2.7	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	2.7	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	2.7	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions

Showing 1 to 10 of 43 entries

Results for POU1F1

Z-value: 2.16

Motif logo

Transcription factors associated with POU1F1

Activity-expression correlation:

Activity profile of POU1F1 motif

Sorted Z-values of POU1F1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of POU1F1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: