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Illumina Body Map 2: averaged replicates
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Results for POU2F2_POU3F1
Z-value: 5.57
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Transcription factors associated with POU2F2_POU3F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU2F2 | hg19_v2_chr19_-_42636617_42636632 | 0.59 | 3.3e-04 | Click! |
| POU3F1 | hg19_v2_chr1_-_38512450_38512474 | -0.36 | 4.2e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_106552755 Show fit | 38.56 |
ENST00000390600.2
|
immunoglobulin heavy variable 3-9 |
|
| chr14_-_106692191 Show fit | 35.70 |
ENST00000390607.2
|
immunoglobulin heavy variable 3-21 |
|
| chr14_-_106573756 Show fit | 34.56 |
ENST00000390601.2
|
immunoglobulin heavy variable 3-11 (gene/pseudogene) |
|
| chr14_-_106994333 Show fit | 32.22 |
ENST00000390624.2
|
immunoglobulin heavy variable 3-48 |
|
| chr14_-_106791536 Show fit | 31.61 |
ENST00000390613.2
|
immunoglobulin heavy variable 3-30 |
|
| chr16_+_32077386 Show fit | 30.26 |
ENST00000354689.6
|
immunoglobulin heavy variable 3/OR16-9 (non-functional) |
|
| chr14_-_106610852 Show fit | 30.11 |
ENST00000390603.2
|
immunoglobulin heavy variable 3-15 |
|
| chr14_-_106586656 Show fit | 29.69 |
ENST00000390602.2
|
immunoglobulin heavy variable 3-13 |
|
| chr16_+_33629600 Show fit | 29.47 |
ENST00000562905.2
|
immunoglobulin heavy variable 3/OR16-13 (non-functional) |
|
| chr14_-_107114267 Show fit | 28.10 |
ENST00000454421.2
|
immunoglobulin heavy variable 3-64 |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU2F2_POU3F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 1005.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.2 | 259.7 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 5.2 | 20.7 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 0.1 | 19.3 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 1.5 | 12.3 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 0.1 | 9.5 | GO:0016239 | positive regulation of macroautophagy(GO:0016239) |
| 3.1 | 9.2 | GO:0070668 | regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668) |
| 0.1 | 7.2 | GO:0072678 | T cell migration(GO:0072678) |
| 0.1 | 7.2 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.9 | 6.9 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.4 | 451.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 317.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.8 | 182.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 153.0 | GO:0005576 | extracellular region(GO:0005576) |
| 0.1 | 14.3 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.3 | 12.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 1.5 | 9.2 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 0.1 | 9.1 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 7.6 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.1 | 7.3 | GO:0000118 | histone deacetylase complex(GO:0000118) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 760.4 | GO:0003823 | antigen binding(GO:0003823) |
| 6.9 | 451.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 5.2 | 20.7 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 0.2 | 17.8 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.2 | 12.7 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.7 | 11.8 | GO:0039706 | co-receptor binding(GO:0039706) |
| 1.4 | 11.6 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 3.3 | 10.0 | GO:0004877 | complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877) |
| 0.3 | 7.2 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.2 | 6.9 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 20.2 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 15.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 14.2 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.2 | 12.1 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.3 | 10.6 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 9.9 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 7.3 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 7.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.6 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 5.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 19.2 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.3 | 10.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.2 | 9.9 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.4 | 9.2 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 7.2 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.3 | 7.1 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.1 | 5.8 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 5.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 4.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 4.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |