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Illumina Body Map 2: averaged replicates

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Results for POU3F3_POU3F4

Z-value: 2.24

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Transcription factors associated with POU3F3_POU3F4

Gene Symbol Gene ID Gene Info
POU3F3
ENSG00000198914.2 POU class 3 homeobox 3
POU3F4
ENSG00000196767.4 POU class 3 homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU3F3hg19_v2_chr2_+_105471969_1054719690.612.0e-04Click!
POU3F4hg19_v2_chrX_+_82763265_827632830.402.4e-02Click!

Activity profile of POU3F3_POU3F4 motif

Sorted Z-values of POU3F3_POU3F4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_158142750 6.55 ENST00000505888.1
ENST00000449365.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr4_-_168155700 6.18 ENST00000357545.4
ENST00000512648.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr4_-_168155577 6.18 ENST00000541354.1
ENST00000509854.1
ENST00000512681.1
ENST00000421836.2
ENST00000510741.1
ENST00000510403.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr9_+_77230499 6.02 ENST00000396204.2
RORB
RAR-related orphan receptor B
chr4_-_168155730 5.87 ENST00000502330.1
ENST00000357154.3
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr12_+_41221794 5.82 ENST00000547849.1
CNTN1
contactin 1
chr4_+_158141899 5.43 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr3_-_58613323 5.32 ENST00000474531.1
ENST00000465970.1
FAM107A
family with sequence similarity 107, member A
chr2_-_183387064 5.30 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr6_-_46459675 5.14 ENST00000306764.7
RCAN2
regulator of calcineurin 2
chr8_-_91095099 4.89 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr3_+_35722487 4.77 ENST00000441454.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr3_+_35722844 4.75 ENST00000436702.1
ENST00000438071.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr15_+_76352178 4.63 ENST00000388942.3
C15orf27
chromosome 15 open reading frame 27
chr5_-_160973649 4.43 ENST00000393959.1
ENST00000517547.1
GABRB2
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr3_+_158787041 4.35 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr11_-_26593649 4.07 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr2_-_166930131 3.99 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr20_+_58203664 3.93 ENST00000541461.1
PHACTR3
phosphatase and actin regulator 3
chr10_-_128359074 3.91 ENST00000544758.1
C10orf90
chromosome 10 open reading frame 90
chr17_+_3379284 3.88 ENST00000263080.2
ASPA
aspartoacylase
chr3_+_35722424 3.70 ENST00000396481.2
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr14_-_21270561 3.54 ENST00000412779.2
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr17_-_66951474 3.46 ENST00000269080.2
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr2_-_183387430 3.44 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr2_-_183387283 3.44 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr13_+_113698946 3.41 ENST00000397021.1
MCF2L
MCF.2 cell line derived transforming sequence-like
chr4_-_87281224 3.40 ENST00000395169.3
ENST00000395161.2
MAPK10
mitogen-activated protein kinase 10
chr18_+_616711 3.40 ENST00000579494.1
CLUL1
clusterin-like 1 (retinal)
chr11_-_26593677 3.37 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr16_-_21314360 3.36 ENST00000219599.3
ENST00000576703.1
CRYM
crystallin, mu
chr4_-_21950356 3.34 ENST00000447367.2
ENST00000382152.2
KCNIP4
Kv channel interacting protein 4
chr10_-_128359008 3.30 ENST00000488181.1
C10orf90
chromosome 10 open reading frame 90
chr7_+_119913688 3.28 ENST00000331113.4
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr15_-_45670717 3.28 ENST00000558163.1
ENST00000558336.1
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr7_-_14880892 3.25 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
DGKB
diacylglycerol kinase, beta 90kDa
chr17_-_50236039 3.19 ENST00000451037.2
CA10
carbonic anhydrase X
chr5_-_11588907 3.15 ENST00000513598.1
ENST00000503622.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr5_-_11589131 3.12 ENST00000511377.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr3_-_100558953 3.11 ENST00000533795.1
ABI3BP
ABI family, member 3 (NESH) binding protein
chrX_+_65382433 3.11 ENST00000374727.3
HEPH
hephaestin
chr14_-_21270995 3.10 ENST00000555698.1
ENST00000397970.4
ENST00000340900.3
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr15_-_45670924 3.05 ENST00000396659.3
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr11_+_8040739 3.03 ENST00000534099.1
TUB
tubby bipartite transcription factor
chr3_-_185826855 2.99 ENST00000306376.5
ETV5
ets variant 5
chr12_+_58003935 2.99 ENST00000333972.7
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chr5_+_140753444 2.98 ENST00000517434.1
PCDHGA6
protocadherin gamma subfamily A, 6
chr7_+_151653464 2.97 ENST00000431418.2
ENST00000392800.2
GALNTL5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
chr18_-_24722995 2.92 ENST00000581714.1
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr16_-_14109841 2.89 ENST00000576797.1
ENST00000575424.1
CTD-2135D7.5
CTD-2135D7.5
chr2_-_183106641 2.83 ENST00000346717.4
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr5_+_140762268 2.81 ENST00000518325.1
PCDHGA7
protocadherin gamma subfamily A, 7
chr10_+_24738355 2.81 ENST00000307544.6
KIAA1217
KIAA1217
chr4_+_88754113 2.79 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chr12_+_41086297 2.78 ENST00000551295.2
CNTN1
contactin 1
chr5_+_175288631 2.78 ENST00000509837.1
CPLX2
complexin 2
chr5_+_36608422 2.77 ENST00000381918.3
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr12_-_91573249 2.75 ENST00000550099.1
ENST00000546391.1
ENST00000551354.1
DCN
decorin
chr14_+_101297740 2.73 ENST00000555928.1
MEG3
maternally expressed 3 (non-protein coding)
chr10_+_68685764 2.72 ENST00000361320.4
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr17_-_38821373 2.69 ENST00000394052.3
KRT222
keratin 222
chr5_+_140529630 2.68 ENST00000543635.1
PCDHB6
protocadherin beta 6
chr3_+_148508845 2.62 ENST00000491148.1
CPB1
carboxypeptidase B1 (tissue)
chr4_-_100575781 2.61 ENST00000511828.1
RP11-766F14.2
Protein LOC285556
chr14_-_61116168 2.56 ENST00000247182.6
SIX1
SIX homeobox 1
chr16_-_10652993 2.47 ENST00000536829.1
EMP2
epithelial membrane protein 2
chr12_-_10324716 2.43 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr1_-_151345159 2.42 ENST00000458566.1
ENST00000447402.3
ENST00000426705.2
ENST00000435071.1
ENST00000368868.5
SELENBP1
selenium binding protein 1
chr11_-_56000737 2.42 ENST00000313264.4
OR5T2
olfactory receptor, family 5, subfamily T, member 2
chr5_-_160279207 2.40 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr13_+_113699029 2.39 ENST00000423251.1
MCF2L
MCF.2 cell line derived transforming sequence-like
chr4_-_186570679 2.39 ENST00000451974.1
SORBS2
sorbin and SH3 domain containing 2
chr11_-_95657231 2.39 ENST00000409459.1
ENST00000352297.7
ENST00000393223.3
ENST00000346299.5
MTMR2
myotubularin related protein 2
chr5_+_125759140 2.34 ENST00000543198.1
GRAMD3
GRAM domain containing 3
chr3_-_196242233 2.34 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr1_+_209602609 2.33 ENST00000458250.1
MIR205HG
MIR205 host gene (non-protein coding)
chr9_+_137967268 2.33 ENST00000371799.4
ENST00000277415.11
OLFM1
olfactomedin 1
chr4_+_158141843 2.29 ENST00000509417.1
ENST00000296526.7
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr2_+_40973618 2.24 ENST00000420187.1
AC007317.1
AC007317.1
chr19_+_18726786 2.22 ENST00000594709.1
TMEM59L
transmembrane protein 59-like
chr1_+_209602156 2.20 ENST00000429156.1
ENST00000366437.3
ENST00000603283.1
ENST00000431096.1
MIR205HG
MIR205 host gene (non-protein coding)
chr12_+_41221975 2.16 ENST00000552913.1
CNTN1
contactin 1
chrX_-_72097698 2.15 ENST00000373530.1
DMRTC1
DMRT-like family C1
chr21_+_17442799 2.12 ENST00000602580.1
ENST00000458468.1
ENST00000602935.1
LINC00478
long intergenic non-protein coding RNA 478
chr19_-_44124019 2.12 ENST00000300811.3
ZNF428
zinc finger protein 428
chrX_+_130192318 2.12 ENST00000370922.1
ARHGAP36
Rho GTPase activating protein 36
chr14_-_80697396 2.12 ENST00000557010.1
DIO2
deiodinase, iodothyronine, type II
chrX_+_72062617 2.08 ENST00000440247.1
DMRTC1B
DMRT-like family C1B
chr15_+_69857515 2.07 ENST00000559477.1
RP11-279F6.1
RP11-279F6.1
chr5_+_125758813 2.04 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr9_+_34458771 2.04 ENST00000437363.1
ENST00000242317.4
DNAI1
dynein, axonemal, intermediate chain 1
chr5_+_125758865 2.03 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr11_-_40314652 2.01 ENST00000527150.1
LRRC4C
leucine rich repeat containing 4C
chr8_-_67090825 1.97 ENST00000276571.3
CRH
corticotropin releasing hormone
chr1_+_170632250 1.96 ENST00000367760.3
PRRX1
paired related homeobox 1
chr18_+_76740189 1.95 ENST00000537592.2
ENST00000575389.2
SALL3
spalt-like transcription factor 3
chr8_-_38008783 1.94 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr2_+_166095898 1.93 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr21_+_17443521 1.92 ENST00000456342.1
LINC00478
long intergenic non-protein coding RNA 478
chr15_-_76304731 1.92 ENST00000394907.3
NRG4
neuregulin 4
chr10_-_128975273 1.92 ENST00000424811.2
FAM196A
family with sequence similarity 196, member A
chr11_-_102709441 1.91 ENST00000434103.1
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr12_+_41086215 1.89 ENST00000547702.1
ENST00000551424.1
CNTN1
contactin 1
chr15_-_76352069 1.89 ENST00000305435.10
ENST00000563910.1
NRG4
neuregulin 4
chrX_-_32173579 1.87 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr3_-_149375783 1.87 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WWTR1
WW domain containing transcription regulator 1
chr8_-_36636676 1.85 ENST00000524132.1
ENST00000519451.1
RP11-962G15.1
RP11-962G15.1
chr6_+_127898312 1.79 ENST00000329722.7
C6orf58
chromosome 6 open reading frame 58
chr10_+_29577974 1.78 ENST00000375500.3
LYZL1
lysozyme-like 1
chr3_-_74570291 1.77 ENST00000263665.6
CNTN3
contactin 3 (plasmacytoma associated)
chr5_+_140710061 1.77 ENST00000517417.1
ENST00000378105.3
PCDHGA1
protocadherin gamma subfamily A, 1
chr1_-_169703203 1.76 ENST00000333360.7
ENST00000367781.4
ENST00000367782.4
ENST00000367780.4
ENST00000367779.4
SELE
selectin E
chr3_+_159943362 1.76 ENST00000326474.3
C3orf80
chromosome 3 open reading frame 80
chr4_-_52883786 1.75 ENST00000343457.3
LRRC66
leucine rich repeat containing 66
chr4_+_9446156 1.73 ENST00000334879.1
DEFB131
defensin, beta 131
chr17_-_10452929 1.73 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
MYH2
myosin, heavy chain 2, skeletal muscle, adult
chr2_+_210444142 1.71 ENST00000360351.4
ENST00000361559.4
MAP2
microtubule-associated protein 2
chr19_-_44123734 1.69 ENST00000598676.1
ZNF428
zinc finger protein 428
chr15_+_71228826 1.68 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
LRRC49
leucine rich repeat containing 49
chr10_-_48806939 1.67 ENST00000374233.3
ENST00000507417.1
ENST00000512321.1
ENST00000395660.2
ENST00000374235.2
ENST00000395661.3
PTPN20B
protein tyrosine phosphatase, non-receptor type 20B
chr7_-_229557 1.67 ENST00000514988.1
AC145676.2
Uncharacterized protein
chr15_-_74658493 1.66 ENST00000419019.2
ENST00000569662.1
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr12_-_91574142 1.63 ENST00000547937.1
DCN
decorin
chr16_-_745946 1.62 ENST00000562563.1
FBXL16
F-box and leucine-rich repeat protein 16
chr5_+_140602904 1.61 ENST00000515856.2
ENST00000239449.4
PCDHB14
protocadherin beta 14
chr9_+_34458851 1.61 ENST00000545019.1
DNAI1
dynein, axonemal, intermediate chain 1
chr3_+_125694347 1.61 ENST00000505382.1
ENST00000511082.1
ROPN1B
rhophilin associated tail protein 1B
chr7_-_15014398 1.60 ENST00000437998.1
DGKB
diacylglycerol kinase, beta 90kDa
chr11_-_88799113 1.60 ENST00000393294.3
GRM5
glutamate receptor, metabotropic 5
chr15_-_74658519 1.57 ENST00000450547.1
ENST00000358632.4
CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr7_-_100026280 1.56 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
ZCWPW1
zinc finger, CW type with PWWP domain 1
chr4_+_30723003 1.53 ENST00000543491.1
PCDH7
protocadherin 7
chr5_-_133702761 1.52 ENST00000521118.1
ENST00000265334.4
ENST00000435211.1
CDKL3
cyclin-dependent kinase-like 3
chr2_+_239335449 1.52 ENST00000264607.4
ASB1
ankyrin repeat and SOCS box containing 1
chr1_+_53925063 1.51 ENST00000371445.3
DMRTB1
DMRT-like family B with proline-rich C-terminal, 1
chr1_+_28099683 1.50 ENST00000373943.4
STX12
syntaxin 12
chr2_-_239140276 1.48 ENST00000334973.4
AC016757.3
Protein LOC151174
chr5_+_140782351 1.47 ENST00000573521.1
PCDHGA9
protocadherin gamma subfamily A, 9
chr7_-_16505440 1.46 ENST00000307068.4
SOSTDC1
sclerostin domain containing 1
chr5_+_140474181 1.46 ENST00000194155.4
PCDHB2
protocadherin beta 2
chr11_-_57004658 1.44 ENST00000606794.1
APLNR
apelin receptor
chr15_-_49255632 1.42 ENST00000332408.4
SHC4
SHC (Src homology 2 domain containing) family, member 4
chr13_+_109248500 1.42 ENST00000356711.2
MYO16
myosin XVI
chr18_-_25739260 1.41 ENST00000413878.1
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr12_-_91573132 1.41 ENST00000550563.1
ENST00000546370.1
DCN
decorin
chr16_+_76311169 1.40 ENST00000307431.8
ENST00000377504.4
CNTNAP4
contactin associated protein-like 4
chr2_-_101034070 1.39 ENST00000264249.3
CHST10
carbohydrate sulfotransferase 10
chr3_-_73610759 1.39 ENST00000466780.1
PDZRN3
PDZ domain containing ring finger 3
chr1_+_28099700 1.38 ENST00000440806.2
STX12
syntaxin 12
chrX_-_112084043 1.36 ENST00000304758.1
AMOT
angiomotin
chr18_+_616672 1.35 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chr5_+_140174429 1.35 ENST00000520672.2
ENST00000378132.1
ENST00000526136.1
PCDHA2
protocadherin alpha 2
chr3_-_78719376 1.35 ENST00000495961.1
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr9_+_137967366 1.34 ENST00000252854.4
OLFM1
olfactomedin 1
chr17_-_66951382 1.34 ENST00000586539.1
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr15_-_30113676 1.34 ENST00000400011.2
TJP1
tight junction protein 1
chr12_-_91573316 1.33 ENST00000393155.1
DCN
decorin
chr12_-_120241187 1.33 ENST00000392520.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr6_+_168418553 1.33 ENST00000354419.2
ENST00000351261.3
KIF25
kinesin family member 25
chrX_-_18690210 1.33 ENST00000379984.3
RS1
retinoschisin 1
chr10_-_75423560 1.31 ENST00000606523.1
SYNPO2L
synaptopodin 2-like
chr3_-_62359180 1.30 ENST00000283268.3
FEZF2
FEZ family zinc finger 2
chr2_-_239140011 1.29 ENST00000409376.1
ENST00000409070.1
ENST00000409942.1
AC016757.3
Protein LOC151174
chr1_-_216978709 1.29 ENST00000360012.3
ESRRG
estrogen-related receptor gamma
chr1_-_193155729 1.28 ENST00000367434.4
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr21_+_17443434 1.28 ENST00000400178.2
LINC00478
long intergenic non-protein coding RNA 478
chr6_-_52859046 1.28 ENST00000457564.1
ENST00000541324.1
ENST00000370960.1
GSTA4
glutathione S-transferase alpha 4
chr15_-_90892669 1.27 ENST00000412799.2
GABARAPL3
GABA(A) receptors associated protein like 3, pseudogene
chr22_+_30476163 1.27 ENST00000336726.6
HORMAD2
HORMA domain containing 2
chr3_+_173116225 1.27 ENST00000457714.1
NLGN1
neuroligin 1
chr16_-_30064244 1.27 ENST00000571269.1
ENST00000561666.1
FAM57B
family with sequence similarity 57, member B
chrX_-_80457385 1.27 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
HMGN5
high mobility group nucleosome binding domain 5
chr12_-_71148413 1.27 ENST00000440835.2
ENST00000549308.1
ENST00000550661.1
PTPRR
protein tyrosine phosphatase, receptor type, R
chr5_+_126984710 1.26 ENST00000379445.3
CTXN3
cortexin 3
chr18_-_48346415 1.25 ENST00000431965.2
ENST00000436348.2
MRO
maestro
chr14_-_47351391 1.25 ENST00000399222.3
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr3_-_73483055 1.25 ENST00000479530.1
PDZRN3
PDZ domain containing ring finger 3
chr3_+_53528659 1.24 ENST00000350061.5
CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr2_+_189839046 1.24 ENST00000304636.3
ENST00000317840.5
COL3A1
collagen, type III, alpha 1
chrX_-_154255143 1.23 ENST00000453950.1
ENST00000423959.1
F8
coagulation factor VIII, procoagulant component
chr8_-_124749609 1.23 ENST00000262219.6
ENST00000419625.1
ANXA13
annexin A13
chr12_-_71148357 1.23 ENST00000378778.1
PTPRR
protein tyrosine phosphatase, receptor type, R
chr20_-_21378666 1.23 ENST00000351817.4
NKX2-4
NK2 homeobox 4
chr8_-_119634141 1.22 ENST00000409003.4
ENST00000526328.1
ENST00000314727.4
ENST00000526765.1
SAMD12
sterile alpha motif domain containing 12
chr2_+_210443993 1.21 ENST00000392193.1
MAP2
microtubule-associated protein 2
chr9_-_15472730 1.21 ENST00000481862.1
PSIP1
PC4 and SFRS1 interacting protein 1
chr4_-_20985632 1.20 ENST00000359001.5
KCNIP4
Kv channel interacting protein 4
chr10_-_124459284 1.20 ENST00000432000.1
ENST00000329446.4
C10orf120
chromosome 10 open reading frame 120
chr3_+_189507523 1.19 ENST00000437221.1
ENST00000392463.2
ENST00000392461.3
ENST00000449992.1
ENST00000456148.1
TP63
tumor protein p63
chrX_+_28605516 1.19 ENST00000378993.1
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr5_-_78809950 1.19 ENST00000334082.6
HOMER1
homer homolog 1 (Drosophila)
chr5_-_42811986 1.19 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
SEPP1
selenoprotein P, plasma, 1
chr5_+_149980622 1.19 ENST00000394243.1
SYNPO
synaptopodin
chr4_-_176708533 1.17 ENST00000507520.1
GPM6A
glycoprotein M6A
chr8_-_65711310 1.17 ENST00000310193.3
CYP7B1
cytochrome P450, family 7, subfamily B, polypeptide 1
chrY_-_20935572 1.17 ENST00000382852.1
ENST00000344884.4
ENST00000304790.3
HSFY2
heat shock transcription factor, Y linked 2
chr4_-_152149033 1.16 ENST00000514152.1
SH3D19
SH3 domain containing 19
chr3_-_33686925 1.15 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr4_+_114066764 1.15 ENST00000511380.1
ANK2
ankyrin 2, neuronal
chr1_+_113009163 1.15 ENST00000256640.5
WNT2B
wingless-type MMTV integration site family, member 2B

Network of associatons between targets according to the STRING database.

First level regulatory network of POU3F3_POU3F4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.3 GO:0006601 creatine biosynthetic process(GO:0006601)
1.3 3.9 GO:0006533 aspartate catabolic process(GO:0006533)
1.1 25.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.8 3.1 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.8 15.0 GO:0046069 cGMP catabolic process(GO:0046069)
0.7 4.9 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.7 2.8 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.7 2.0 GO:0070093 negative regulation of glucagon secretion(GO:0070093) positive regulation of corticosterone secretion(GO:2000854)
0.6 2.6 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.6 6.0 GO:0035881 amacrine cell differentiation(GO:0035881)
0.6 2.9 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.5 1.9 GO:0018963 insecticide metabolic process(GO:0017143) phthalate metabolic process(GO:0018963)
0.5 1.4 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.4 1.3 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.4 4.0 GO:0042078 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.4 2.5 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.3 3.8 GO:0070779 gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.3 2.8 GO:0031642 negative regulation of myelination(GO:0031642)
0.3 1.3 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.3 1.3 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.3 5.1 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.3 1.3 GO:0048789 cytoskeletal matrix organization at active zone(GO:0048789) neurexin clustering involved in presynaptic membrane assembly(GO:0097115) retrograde trans-synaptic signaling by trans-synaptic protein complex(GO:0098942)
0.3 4.8 GO:0042908 xenobiotic transport(GO:0042908)
0.3 1.5 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.3 3.4 GO:0003190 atrioventricular valve formation(GO:0003190)
0.3 3.0 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.3 0.8 GO:2000612 thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.3 3.3 GO:0048664 neuron fate determination(GO:0048664)
0.3 5.1 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.3 1.3 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.3 2.4 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.2 3.4 GO:0007258 JUN phosphorylation(GO:0007258)
0.2 1.0 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.2 3.4 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 14.8 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2 0.6 GO:0018315 molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.2 0.6 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.2 2.5 GO:0070836 caveola assembly(GO:0070836)
0.2 1.6 GO:0046952 ketone body catabolic process(GO:0046952)
0.2 1.2 GO:0098886 modification of dendritic spine(GO:0098886)
0.2 4.4 GO:0071420 cellular response to histamine(GO:0071420)
0.2 14.3 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.2 1.4 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.2 3.3 GO:0045475 locomotor rhythm(GO:0045475)
0.2 1.2 GO:0035754 B cell chemotaxis(GO:0035754)
0.2 1.4 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.2 0.6 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.1 1.2 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.1 3.6 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 1.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.5 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.1 5.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.5 GO:1903487 regulation of lactation(GO:1903487)
0.1 1.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 2.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 4.5 GO:0006825 copper ion transport(GO:0006825)
0.1 2.7 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 1.1 GO:0060492 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.1 0.8 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.1 1.0 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 0.6 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 2.1 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 1.7 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.7 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 2.0 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.1 1.9 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.1 0.2 GO:0005513 detection of calcium ion(GO:0005513)
0.1 0.3 GO:1904956 neural crest cell fate commitment(GO:0014034) cellular response to heparin(GO:0071504) regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.1 2.8 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.1 1.4 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 2.4 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 1.1 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.1 1.1 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.1 1.3 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 1.4 GO:2000821 regulation of grooming behavior(GO:2000821)
0.1 4.8 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 3.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 1.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.7 GO:1903286 regulation of potassium ion import(GO:1903286)
0.1 3.2 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.1 1.0 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.1 1.6 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.1 1.5 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.1 6.3 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.1 2.4 GO:0045332 phospholipid translocation(GO:0045332)
0.1 1.9 GO:1903209 positive regulation of oxidative stress-induced cell death(GO:1903209)
0.1 0.8 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 2.9 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 0.6 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 6.7 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 1.8 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.1 1.2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 7.4 GO:0016266 O-glycan processing(GO:0016266)
0.1 12.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 4.8 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.1 1.5 GO:0030539 male genitalia development(GO:0030539)
0.1 0.8 GO:0060856 establishment of blood-brain barrier(GO:0060856)
0.1 1.3 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 0.8 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 0.3 GO:0072695 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.1 0.2 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.1 0.7 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.1 1.2 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 1.4 GO:0048863 stem cell differentiation(GO:0048863)
0.0 0.1 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.0 0.6 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 12.0 GO:0034605 cellular response to heat(GO:0034605)
0.0 2.9 GO:0033344 cholesterol efflux(GO:0033344)
0.0 3.4 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.3 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.8 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 1.3 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 1.0 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.8 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0 3.5 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.8 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 0.7 GO:0072189 ureter development(GO:0072189)
0.0 0.9 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.0 0.2 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 1.3 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.0 0.3 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 3.5 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.0 0.5 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.5 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.0 1.3 GO:0021522 spinal cord motor neuron differentiation(GO:0021522)
0.0 0.4 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.5 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.6 GO:0032026 response to magnesium ion(GO:0032026)
0.0 0.1 GO:0090131 mesenchyme migration(GO:0090131)
0.0 1.4 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 6.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.3 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 0.1 GO:0018277 protein deamination(GO:0018277)
0.0 0.2 GO:0046078 dUMP metabolic process(GO:0046078)
0.0 1.3 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.8 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.8 GO:0090383 phagosome acidification(GO:0090383)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.9 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 3.0 GO:0007286 spermatid development(GO:0007286)
0.0 0.5 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.4 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 1.1 GO:0003281 ventricular septum development(GO:0003281)
0.0 0.3 GO:0044458 motile cilium assembly(GO:0044458)
0.0 2.8 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 4.1 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 0.3 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 1.7 GO:0021549 cerebellum development(GO:0021549)
0.0 1.6 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.6 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 1.2 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.5 GO:0002323 natural killer cell activation involved in immune response(GO:0002323)
0.0 0.7 GO:0033260 DNA replication initiation(GO:0006270) nuclear DNA replication(GO:0033260)
0.0 0.2 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.3 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 2.7 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 14.3 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.5 7.5 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.4 1.2 GO:0097444 spine apparatus(GO:0097444)
0.3 3.6 GO:0036157 outer dynein arm(GO:0036157)
0.3 2.8 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.3 2.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.3 6.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 2.0 GO:0043196 varicosity(GO:0043196)
0.2 1.7 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 1.9 GO:0016013 syntrophin complex(GO:0016013)
0.1 3.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 1.9 GO:0030061 mitochondrial crista(GO:0030061)
0.1 4.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 4.5 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.5 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 3.1 GO:0005614 interstitial matrix(GO:0005614)
0.1 2.9 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 0.7 GO:0002177 manchette(GO:0002177)
0.1 0.3 GO:0097224 sperm connecting piece(GO:0097224)
0.1 3.3 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 1.3 GO:0045180 basal cortex(GO:0045180)
0.1 1.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.4 GO:0016342 catenin complex(GO:0016342)
0.1 1.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 1.3 GO:0032433 filopodium tip(GO:0032433)
0.1 0.6 GO:1990812 growth cone filopodium(GO:1990812)
0.1 0.5 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 0.5 GO:0033263 CORVET complex(GO:0033263)
0.1 1.1 GO:0043194 axon initial segment(GO:0043194)
0.1 0.7 GO:0033268 node of Ranvier(GO:0033268)
0.1 0.6 GO:0032437 cuticular plate(GO:0032437)
0.1 5.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 7.8 GO:0005796 Golgi lumen(GO:0005796)
0.1 5.7 GO:0043195 terminal bouton(GO:0043195)
0.0 2.5 GO:0043034 costamere(GO:0043034)
0.0 1.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 11.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 21.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.2 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.5 GO:0030478 actin cap(GO:0030478)
0.0 3.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.5 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.4 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.7 GO:0031045 dense core granule(GO:0031045)
0.0 3.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.3 GO:0005921 gap junction(GO:0005921)
0.0 0.8 GO:0032982 myosin filament(GO:0032982)
0.0 6.2 GO:0016363 nuclear matrix(GO:0016363)
0.0 3.8 GO:0005901 caveola(GO:0005901)
0.0 0.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.9 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0061617 MICOS complex(GO:0061617)
0.0 18.0 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.3 GO:0070187 telosome(GO:0070187)
0.0 1.4 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.3 GO:0042587 glycogen granule(GO:0042587)
0.0 1.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.1 GO:0031941 filamentous actin(GO:0031941)
0.0 0.7 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 1.5 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.9 GO:0016459 myosin complex(GO:0016459)
0.0 0.7 GO:0005771 multivesicular body(GO:0005771)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.6 GO:0005871 kinesin complex(GO:0005871)
0.0 1.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.3 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.4 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 1.1 GO:0034704 calcium channel complex(GO:0034704)
0.0 2.0 GO:0043197 dendritic spine(GO:0043197)
0.0 1.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 3.4 GO:0030017 sarcomere(GO:0030017)
0.0 0.7 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.6 GO:0032420 stereocilium(GO:0032420)
0.0 8.6 GO:0005813 centrosome(GO:0005813)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 15.0 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
2.1 6.3 GO:0015067 amidinotransferase activity(GO:0015067) glycine amidinotransferase activity(GO:0015068)
1.1 3.2 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386)
0.9 6.6 GO:0004522 ribonuclease A activity(GO:0004522)
0.8 3.4 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.8 14.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.7 5.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.7 4.9 GO:0005499 vitamin D binding(GO:0005499)
0.6 18.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.6 4.4 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.5 2.0 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.5 2.8 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.4 1.3 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.4 2.9 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.4 1.6 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.4 3.9 GO:0004046 aminoacylase activity(GO:0004046)
0.4 3.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 4.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.4 4.8 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.4 3.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.3 3.4 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.3 1.6 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.3 2.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.2 0.6 GO:0061599 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.2 6.8 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.2 1.4 GO:0043532 angiostatin binding(GO:0043532)
0.2 3.1 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.2 6.1 GO:0002162 dystroglycan binding(GO:0002162)
0.2 1.5 GO:0098821 BMP receptor activity(GO:0098821)
0.2 4.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 2.4 GO:0008430 selenium binding(GO:0008430)
0.2 0.5 GO:0019150 D-ribulokinase activity(GO:0019150)
0.2 0.8 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.2 1.3 GO:0050682 AF-2 domain binding(GO:0050682)
0.2 0.6 GO:0004802 transketolase activity(GO:0004802)
0.2 3.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 13.3 GO:0042805 actinin binding(GO:0042805)
0.2 0.6 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.1 3.2 GO:0070492 oligosaccharide binding(GO:0070492)
0.1 1.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 2.3 GO:0003796 lysozyme activity(GO:0003796)
0.1 5.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.8 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.1 0.6 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.1 0.5 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 2.4 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.1 1.5 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 1.2 GO:0097100 supercoiled DNA binding(GO:0097100)
0.1 0.4 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.1 2.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 7.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.6 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.1 2.6 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 0.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 1.9 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 0.1 GO:0032427 GBD domain binding(GO:0032427)
0.1 1.2 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 1.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 1.2 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 1.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 2.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 0.4 GO:0050733 RS domain binding(GO:0050733)
0.1 0.3 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.1 2.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.7 GO:0097016 L27 domain binding(GO:0097016)
0.0 1.1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 2.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 16.8 GO:0005516 calmodulin binding(GO:0005516)
0.0 6.0 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 9.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 1.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.6 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.4 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 1.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.3 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.2 GO:0051731 polynucleotide 5'-hydroxyl-kinase activity(GO:0051731)
0.0 0.5 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 1.0 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 1.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 3.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 3.5 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.2 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 1.5 GO:0030507 spectrin binding(GO:0030507)
0.0 0.7 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 4.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.5 GO:0089720 caspase binding(GO:0089720)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.9 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.8 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.5 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.3 GO:0032027 myosin light chain binding(GO:0032027)
0.0 1.0 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 1.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 1.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 1.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.6 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.3 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 2.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.4 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 0.3 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 1.2 GO:0005507 copper ion binding(GO:0005507)
0.0 0.4 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.9 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.7 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.4 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.4 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.0 0.2 GO:0033038 bitter taste receptor activity(GO:0033038)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 25.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 15.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 8.8 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 11.2 PID NOTCH PATHWAY Notch signaling pathway
0.1 4.7 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 4.0 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 3.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 2.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 3.7 PID P73PATHWAY p73 transcription factor network
0.0 1.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 2.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.8 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.6 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.0 PID ATR PATHWAY ATR signaling pathway
0.0 1.0 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 1.5 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 3.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 15.1 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.3 15.0 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.2 10.0 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 10.7 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 2.8 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.2 7.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 3.7 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.1 1.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 4.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 3.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 4.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 5.9 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 2.9 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 4.9 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 5.3 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.1 4.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.1 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 7.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.9 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 1.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 3.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 1.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 1.2 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 3.8 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 2.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 2.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.6 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 1.0 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.6 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 1.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 3.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.7 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 5.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.9 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 3.4 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.7 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 2.0 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism