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Illumina Body Map 2: averaged replicates
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Results for POU3F3_POU3F4
Z-value: 2.24
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Transcription factors associated with POU3F3_POU3F4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU3F3 | hg19_v2_chr2_+_105471969_105471969 | 0.61 | 2.0e-04 | Click! |
| POU3F4 | hg19_v2_chrX_+_82763265_82763283 | 0.40 | 2.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU3F3_POU3F4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 25.3 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.8 | 15.0 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.2 | 14.8 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.2 | 14.3 | GO:0010765 | positive regulation of sodium ion transport(GO:0010765) |
| 0.1 | 12.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 12.0 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.1 | 7.4 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 6.7 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502) |
| 0.0 | 6.5 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 1.6 | 6.3 | GO:0006601 | creatine biosynthetic process(GO:0006601) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.6 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 18.0 | GO:0043025 | neuronal cell body(GO:0043025) |
| 2.0 | 14.3 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 0.0 | 11.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 8.6 | GO:0005813 | centrosome(GO:0005813) |
| 0.1 | 7.8 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.5 | 7.5 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.3 | 6.8 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 6.2 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 5.7 | GO:0043195 | terminal bouton(GO:0043195) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 18.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 16.8 | GO:0005516 | calmodulin binding(GO:0005516) |
| 2.1 | 15.0 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.8 | 14.3 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.2 | 13.3 | GO:0042805 | actinin binding(GO:0042805) |
| 0.0 | 9.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 7.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 6.8 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.9 | 6.6 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 2.1 | 6.3 | GO:0015067 | amidinotransferase activity(GO:0015067) glycine amidinotransferase activity(GO:0015068) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 15.7 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 11.2 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 8.8 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 4.7 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 4.0 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 3.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 3.7 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 3.3 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 2.9 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.1 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.3 | 15.0 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.2 | 10.7 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.2 | 10.0 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.2 | 7.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 7.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 5.9 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 5.3 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.0 | 5.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 4.9 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |