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Illumina Body Map 2: averaged replicates
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Results for POU5F1_POU2F3
Z-value: 7.16
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Transcription factors associated with POU5F1_POU2F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU5F1 | hg19_v2_chr6_-_31138439_31138475 | 0.32 | 7.6e-02 | Click! |
| POU2F3 | hg19_v2_chr11_+_120107344_120107351 | 0.26 | 1.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_23063100 Show fit | 30.57 |
ENST00000390309.2
|
immunoglobulin lambda variable 3-19 |
|
| chr14_-_107049312 Show fit | 26.05 |
ENST00000390627.2
|
immunoglobulin heavy variable 3-53 |
|
| chr22_+_23154239 Show fit | 24.74 |
ENST00000390315.2
|
immunoglobulin lambda variable 3-10 |
|
| chr22_+_23089870 Show fit | 24.55 |
ENST00000390311.2
|
immunoglobulin lambda variable 3-16 |
|
| chr14_-_106552755 Show fit | 24.07 |
ENST00000390600.2
|
immunoglobulin heavy variable 3-9 |
|
| chr14_-_107035208 Show fit | 23.78 |
ENST00000390626.2
|
immunoglobulin heavy variable 5-51 |
|
| chr22_+_22764088 Show fit | 22.86 |
ENST00000390299.2
|
immunoglobulin lambda variable 1-40 |
|
| chr22_+_22735135 Show fit | 22.43 |
ENST00000390297.2
|
immunoglobulin lambda variable 1-44 |
|
| chr14_-_107170409 Show fit | 22.42 |
ENST00000390633.2
|
immunoglobulin heavy variable 1-69 |
|
| chr2_+_89998789 Show fit | 22.21 |
ENST00000453166.2
|
immunoglobulin kappa variable 2D-28 |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU5F1_POU2F3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.9 | 1195.1 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 2.3 | 520.8 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 8.0 | 32.0 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 0.3 | 27.1 | GO:0045576 | mast cell activation(GO:0045576) |
| 7.6 | 22.9 | GO:0035700 | astrocyte chemotaxis(GO:0035700) regulation of astrocyte chemotaxis(GO:2000458) |
| 0.9 | 22.4 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.4 | 22.2 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
| 0.0 | 20.6 | GO:0043312 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 0.1 | 20.0 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.2 | 19.2 | GO:0030183 | B cell differentiation(GO:0030183) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 514.4 | GO:0005615 | extracellular space(GO:0005615) |
| 7.5 | 403.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 292.4 | GO:0005576 | extracellular region(GO:0005576) |
| 1.0 | 225.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.6 | 43.0 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 39.1 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.2 | 35.7 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.3 | 19.3 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.7 | 15.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.8 | 14.7 | GO:0033093 | Weibel-Palade body(GO:0033093) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 1239.3 | GO:0003823 | antigen binding(GO:0003823) |
| 5.9 | 386.7 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.3 | 35.1 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 8.0 | 32.0 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 1.9 | 30.9 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 1.0 | 22.4 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.9 | 22.2 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.6 | 19.3 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 18.8 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.7 | 18.4 | GO:0050700 | CARD domain binding(GO:0050700) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 55.7 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.5 | 55.4 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.4 | 28.4 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.5 | 25.9 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.6 | 20.6 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.2 | 19.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 18.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.4 | 16.8 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 15.7 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.3 | 10.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 40.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.4 | 38.7 | REACTOME TCR SIGNALING | Genes involved in TCR signaling |
| 0.1 | 29.4 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 28.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.6 | 27.1 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.4 | 23.8 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.2 | 22.6 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.2 | 14.6 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.1 | 13.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 11.0 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |