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Illumina Body Map 2: averaged replicates

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Results for PPARD

Z-value: 1.52

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Transcription factors associated with PPARD

Gene Symbol Gene ID Gene Info
PPARD
ENSG00000112033.9 peroxisome proliferator activated receptor delta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PPARDhg19_v2_chr6_+_35310391_35310410-0.421.6e-02Click!

Activity profile of PPARD motif

Sorted Z-values of PPARD motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_4153598 8.49 ENST00000078445.2
ENST00000252587.3
ENST00000595923.1
ENST00000602257.1
ENST00000602147.1
CREB3L3
cAMP responsive element binding protein 3-like 3
chr1_-_120311517 6.89 ENST00000369406.3
ENST00000544913.2
HMGCS2
3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
chr1_-_161193349 6.68 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2
apolipoprotein A-II
chr6_+_43265992 6.51 ENST00000449231.1
ENST00000372589.3
ENST00000372585.5
SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chr6_+_43266063 5.41 ENST00000372574.3
SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chr10_-_74714533 5.23 ENST00000373032.3
PLA2G12B
phospholipase A2, group XIIB
chr3_+_186383741 4.77 ENST00000232003.4
HRG
histidine-rich glycoprotein
chr4_+_159593418 4.17 ENST00000507475.1
ENST00000307738.5
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr1_+_145727681 3.86 ENST00000417171.1
ENST00000451928.2
PDZK1
PDZ domain containing 1
chr3_+_46538981 3.86 ENST00000296142.3
RTP3
receptor (chemosensory) transporter protein 3
chr22_-_42526802 3.33 ENST00000359033.4
ENST00000389970.3
ENST00000360608.5
CYP2D6
cytochrome P450, family 2, subfamily D, polypeptide 6
chr12_-_53320245 3.30 ENST00000552150.1
KRT8
keratin 8
chr3_-_126236605 2.96 ENST00000290868.2
UROC1
urocanate hydratase 1
chr17_+_37894179 2.93 ENST00000577695.1
ENST00000309156.4
ENST00000309185.3
GRB7
growth factor receptor-bound protein 7
chr9_-_33402506 2.90 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
AQP7
aquaporin 7
chr1_-_11107280 2.87 ENST00000400897.3
ENST00000400898.3
MASP2
mannan-binding lectin serine peptidase 2
chr9_+_126773880 2.86 ENST00000373615.4
LHX2
LIM homeobox 2
chr1_+_6511651 2.84 ENST00000434576.1
ESPN
espin
chr3_-_126236588 2.80 ENST00000383579.3
UROC1
urocanate hydratase 1
chr12_-_21757774 2.79 ENST00000261195.2
GYS2
glycogen synthase 2 (liver)
chr3_-_187009798 2.75 ENST00000337774.5
MASP1
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
chr18_-_47340297 2.67 ENST00000586485.1
ENST00000587994.1
ENST00000586100.1
ENST00000285093.10
ACAA2
acetyl-CoA acyltransferase 2
chr13_+_113760098 2.61 ENST00000346342.3
ENST00000541084.1
ENST00000375581.3
F7
coagulation factor VII (serum prothrombin conversion accelerator)
chr3_-_187009646 2.59 ENST00000296280.6
ENST00000392470.2
ENST00000169293.6
ENST00000439271.1
ENST00000392472.2
ENST00000392475.2
MASP1
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
chr20_+_42187682 2.50 ENST00000373092.3
ENST00000373077.1
SGK2
serum/glucocorticoid regulated kinase 2
chr6_+_32006159 2.22 ENST00000478281.1
ENST00000471671.1
ENST00000435122.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr2_+_120125245 2.11 ENST00000393103.2
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr20_+_42187608 2.10 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chr2_-_28113217 2.07 ENST00000444339.2
RBKS
ribokinase
chr7_-_87342564 1.97 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr6_+_32006042 1.96 ENST00000418967.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chrX_+_2746850 1.92 ENST00000381163.3
ENST00000338623.5
ENST00000542787.1
GYG2
glycogenin 2
chr19_-_51869592 1.90 ENST00000596253.1
ENST00000309244.4
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr17_+_7123207 1.90 ENST00000584103.1
ENST00000579886.2
ACADVL
acyl-CoA dehydrogenase, very long chain
chr17_+_4802713 1.89 ENST00000521575.1
ENST00000381365.3
C17orf107
chromosome 17 open reading frame 107
chr3_-_53878644 1.88 ENST00000481668.1
ENST00000467802.1
CHDH
choline dehydrogenase
chr17_+_7123125 1.87 ENST00000356839.5
ENST00000583312.1
ENST00000350303.5
ACADVL
acyl-CoA dehydrogenase, very long chain
chr3_-_48936272 1.82 ENST00000544097.1
ENST00000430379.1
ENST00000319017.4
SLC25A20
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chrX_+_2746818 1.80 ENST00000398806.3
GYG2
glycogenin 2
chr17_-_34345002 1.76 ENST00000293280.2
CCL23
chemokine (C-C motif) ligand 23
chr17_-_34344991 1.61 ENST00000591423.1
CCL23
chemokine (C-C motif) ligand 23
chr4_+_140586922 1.57 ENST00000265498.1
ENST00000506797.1
MGST2
microsomal glutathione S-transferase 2
chr9_+_115142217 1.47 ENST00000398805.3
ENST00000398803.1
ENST00000262542.7
ENST00000539114.1
HSDL2
hydroxysteroid dehydrogenase like 2
chr3_-_187009468 1.40 ENST00000425937.1
MASP1
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
chr15_+_43885252 1.38 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr11_+_17281900 1.38 ENST00000530527.1
NUCB2
nucleobindin 2
chr15_+_43985084 1.37 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr1_-_197036364 1.35 ENST00000367412.1
F13B
coagulation factor XIII, B polypeptide
chr17_+_4853442 1.26 ENST00000522301.1
ENO3
enolase 3 (beta, muscle)
chr2_+_219283815 1.20 ENST00000248444.5
ENST00000454069.1
ENST00000392114.2
VIL1
villin 1
chr4_+_159593271 1.19 ENST00000512251.1
ENST00000511912.1
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr20_+_39969519 1.15 ENST00000373257.3
LPIN3
lipin 3
chrX_+_38211777 1.13 ENST00000039007.4
OTC
ornithine carbamoyltransferase
chr17_+_9745786 1.12 ENST00000304773.5
GLP2R
glucagon-like peptide 2 receptor
chr6_+_33172407 1.07 ENST00000374662.3
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr2_+_198365095 1.06 ENST00000409468.1
HSPE1
heat shock 10kDa protein 1
chr12_-_56727676 1.04 ENST00000547572.1
ENST00000257931.5
ENST00000440411.3
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr21_-_27107881 1.02 ENST00000400090.3
ENST00000400087.3
ENST00000400093.3
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr17_+_48610042 1.02 ENST00000503246.1
EPN3
epsin 3
chr19_-_10687983 1.01 ENST00000587069.1
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr8_-_80942467 0.98 ENST00000518271.1
ENST00000276585.4
ENST00000521605.1
MRPS28
mitochondrial ribosomal protein S28
chr14_+_32546274 0.97 ENST00000396582.2
ARHGAP5
Rho GTPase activating protein 5
chr17_+_48610074 0.93 ENST00000503690.1
ENST00000514874.1
ENST00000537145.1
ENST00000541226.1
EPN3
epsin 3
chr14_-_51561784 0.92 ENST00000360392.4
TRIM9
tripartite motif containing 9
chr8_+_145065705 0.89 ENST00000533044.1
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr12_+_121163602 0.82 ENST00000411593.2
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr7_-_34978980 0.79 ENST00000428054.1
DPY19L1
dpy-19-like 1 (C. elegans)
chr12_-_56727487 0.79 ENST00000548043.1
ENST00000425394.2
PAN2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr1_-_160253998 0.76 ENST00000392220.2
PEX19
peroxisomal biogenesis factor 19
chr11_-_119599794 0.76 ENST00000264025.3
PVRL1
poliovirus receptor-related 1 (herpesvirus entry mediator C)
chr10_-_94050820 0.71 ENST00000265997.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr8_-_80942061 0.71 ENST00000519386.1
MRPS28
mitochondrial ribosomal protein S28
chr21_-_27107344 0.69 ENST00000457143.2
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr14_+_32546145 0.69 ENST00000556611.1
ENST00000539826.2
ARHGAP5
Rho GTPase activating protein 5
chr19_+_10196981 0.67 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr16_-_75285380 0.66 ENST00000393420.6
ENST00000162330.5
BCAR1
breast cancer anti-estrogen resistance 1
chr19_+_10197463 0.66 ENST00000590378.1
ENST00000397881.3
C19orf66
chromosome 19 open reading frame 66
chr2_+_198365122 0.61 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr21_-_27107198 0.60 ENST00000400094.1
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr12_+_121163538 0.59 ENST00000242592.4
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr8_-_80942139 0.59 ENST00000521434.1
ENST00000519120.1
ENST00000520946.1
MRPS28
mitochondrial ribosomal protein S28
chr7_+_7222157 0.58 ENST00000419721.1
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr2_-_198364552 0.58 ENST00000439605.1
ENST00000418022.1
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr1_-_109968973 0.54 ENST00000271308.4
ENST00000538610.1
PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr2_-_207024134 0.54 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr2_+_115919684 0.53 ENST00000310323.8
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr2_-_198364581 0.52 ENST00000428204.1
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr21_-_27107283 0.52 ENST00000284971.3
ENST00000400099.1
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr19_-_49339080 0.46 ENST00000595764.1
HSD17B14
hydroxysteroid (17-beta) dehydrogenase 14
chr17_+_73997419 0.45 ENST00000425876.2
CDK3
cyclin-dependent kinase 3
chr9_+_35042205 0.43 ENST00000312292.5
ENST00000378745.3
C9orf131
chromosome 9 open reading frame 131
chr8_+_145065521 0.39 ENST00000534791.1
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr19_+_29493486 0.37 ENST00000589821.1
CTD-2081K17.2
CTD-2081K17.2
chr4_-_7069760 0.36 ENST00000264954.4
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr9_+_131901661 0.34 ENST00000423100.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr1_+_62417957 0.33 ENST00000307297.7
ENST00000543708.1
INADL
InaD-like (Drosophila)
chr9_+_131037623 0.33 ENST00000495313.1
ENST00000372898.2
SWI5
SWI5 recombination repair homolog (yeast)
chr19_+_29493456 0.32 ENST00000591143.1
ENST00000592653.1
CTD-2081K17.2
CTD-2081K17.2
chr17_-_4464081 0.31 ENST00000574154.1
GGT6
gamma-glutamyltransferase 6
chr2_+_206547215 0.29 ENST00000360409.3
ENST00000540178.1
ENST00000540841.1
ENST00000355117.4
ENST00000450507.1
ENST00000417189.1
NRP2
neuropilin 2
chr16_-_28303360 0.27 ENST00000501520.1
RP11-57A19.2
RP11-57A19.2
chr19_-_10687948 0.26 ENST00000592285.1
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr6_-_88299678 0.26 ENST00000369536.5
RARS2
arginyl-tRNA synthetase 2, mitochondrial
chr2_-_99871570 0.25 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
LYG2
lysozyme G-like 2
chr2_+_95940186 0.24 ENST00000403131.2
ENST00000317668.4
ENST00000317620.9
PROM2
prominin 2
chr6_+_142468383 0.24 ENST00000367621.1
ENST00000452973.2
VTA1
vesicle (multivesicular body) trafficking 1
chr16_-_4401284 0.23 ENST00000318059.3
PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr7_+_7222233 0.19 ENST00000436587.2
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr12_-_109797249 0.14 ENST00000538041.1
RP11-256L11.1
RP11-256L11.1
chr5_-_143550159 0.12 ENST00000448443.2
ENST00000513112.1
ENST00000519064.1
ENST00000274496.5
YIPF5
Yip1 domain family, member 5
chr1_+_244998602 0.10 ENST00000411948.2
COX20
COX20 cytochrome C oxidase assembly factor
chr11_+_7595136 0.10 ENST00000529575.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr14_+_74551650 0.10 ENST00000554938.1
LIN52
lin-52 homolog (C. elegans)
chr21_+_27107672 0.09 ENST00000400075.3
GABPA
GA binding protein transcription factor, alpha subunit 60kDa
chr1_-_43855444 0.08 ENST00000372455.4
MED8
mediator complex subunit 8
chr6_+_142468361 0.07 ENST00000367630.4
VTA1
vesicle (multivesicular body) trafficking 1
chr1_-_43855479 0.06 ENST00000290663.6
ENST00000372457.4
MED8
mediator complex subunit 8
chr12_+_131438443 0.06 ENST00000261654.5
GPR133
G protein-coupled receptor 133
chr17_-_34270668 0.06 ENST00000293274.4
LYZL6
lysozyme-like 6
chr1_-_11863171 0.05 ENST00000376592.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr6_+_88299833 0.05 ENST00000392844.3
ENST00000257789.4
ENST00000546266.1
ENST00000417380.2
ORC3
origin recognition complex, subunit 3
chr12_-_95467267 0.02 ENST00000330677.7
NR2C1
nuclear receptor subfamily 2, group C, member 1
chr11_+_64073699 0.01 ENST00000405666.1
ENST00000468670.1
ESRRA
estrogen-related receptor alpha
chr1_+_165864821 0.00 ENST00000470820.1
UCK2
uridine-cytidine kinase 2

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARD

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 GO:2000910 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
1.2 4.8 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.8 3.3 GO:0033076 alkaloid catabolic process(GO:0009822) isoquinoline alkaloid metabolic process(GO:0033076) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346)
0.8 5.8 GO:0019557 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.6 9.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.5 8.5 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.5 2.6 GO:1905225 response to thyrotropin-releasing hormone(GO:1905225)
0.5 11.0 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.5 1.9 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.5 1.8 GO:1902616 acyl carnitine transport(GO:0006844) acyl carnitine transmembrane transport(GO:1902616)
0.4 2.7 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.4 2.1 GO:0019303 D-ribose catabolic process(GO:0019303)
0.4 6.9 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.4 1.1 GO:0070781 arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
0.4 1.1 GO:0002368 B cell cytokine production(GO:0002368) protein import into mitochondrial intermembrane space(GO:0045041)
0.3 2.9 GO:0015793 glycerol transport(GO:0015793)
0.2 2.0 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.2 0.7 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.2 0.9 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.2 11.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 4.2 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.2 3.3 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.2 0.8 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.2 2.8 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.2 1.2 GO:1902896 terminal web assembly(GO:1902896)
0.2 2.9 GO:0021978 telencephalon regionalization(GO:0021978)
0.1 2.9 GO:0034063 stress granule assembly(GO:0034063)
0.1 3.6 GO:0015879 carnitine transport(GO:0015879)
0.1 5.2 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.1 2.1 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.1 2.8 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 1.4 GO:0006600 creatine metabolic process(GO:0006600)
0.1 3.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 1.9 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.1 3.7 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 0.8 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 1.5 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 0.2 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 1.1 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 3.4 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.3 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.8 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.0 1.2 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 2.8 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 1.3 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0 0.3 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 4.6 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.0 1.8 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.5 GO:0045023 G0 to G1 transition(GO:0045023)
0.0 1.3 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.6 GO:0006457 protein folding(GO:0006457)
0.0 0.3 GO:0045003 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.3 GO:0097490 sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491)
0.0 2.3 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.3 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.0 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 1.1 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.1 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0031251 PAN complex(GO:0031251)
0.4 6.7 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.2 2.8 GO:0032426 stereocilium tip(GO:0032426)
0.2 5.4 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1 2.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 4.8 GO:0036019 endolysosome(GO:0036019)
0.1 1.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.6 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 4.1 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.5 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.1 0.3 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.1 3.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 2.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 3.8 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.2 GO:0032433 filopodium tip(GO:0032433)
0.0 0.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 16.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.7 GO:0097440 apical dendrite(GO:0097440)
0.0 9.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 2.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.0 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 3.0 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 1.7 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.4 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.0 GO:0010494 cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.9 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
1.8 5.4 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
1.7 6.7 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.7 3.7 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.7 2.9 GO:0001855 complement component C4b binding(GO:0001855)
0.6 2.9 GO:0015254 glycerol channel activity(GO:0015254)
0.6 3.9 GO:0031849 olfactory receptor binding(GO:0031849)
0.5 1.6 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.5 2.0 GO:1990175 EH domain binding(GO:1990175)
0.5 3.9 GO:0005124 scavenger receptor binding(GO:0005124)
0.5 3.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.5 3.8 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.5 1.8 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.4 1.1 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.3 2.8 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.3 2.0 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.3 1.1 GO:0004967 glucagon receptor activity(GO:0004967)
0.3 2.7 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.3 8.5 GO:0035497 cAMP response element binding(GO:0035497)
0.2 11.9 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.2 1.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.2 2.1 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 0.8 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.2 1.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 7.5 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.2 4.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 1.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 4.6 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 1.4 GO:0004111 creatine kinase activity(GO:0004111)
0.1 1.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 5.2 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 1.4 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 5.3 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 1.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.5 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.1 0.8 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 6.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 1.1 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.3 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 2.1 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.7 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.8 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 1.7 GO:0042169 SH2 domain binding(GO:0042169)
0.0 2.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 2.1 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.3 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.5 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 1.9 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.8 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 1.5 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 3.1 GO:0017124 SH3 domain binding(GO:0017124)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 16.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 7.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 3.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 3.1 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 2.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.8 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 1.7 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.1 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 9.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.4 11.9 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.2 5.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 6.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 2.9 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 3.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.2 4.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.2 2.0 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 2.6 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 3.7 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 2.8 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 7.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 2.9 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 1.6 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 4.0 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 4.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 6.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 10.2 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.8 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.1 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.4 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions