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Illumina Body Map 2: averaged replicates
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Results for PPARG
Z-value: 2.46
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Transcription factors associated with PPARG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PPARG | hg19_v2_chr3_+_12329397_12329433 | 0.28 | 1.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_49864746 Show fit | 10.32 |
ENST00000598810.1
|
TEA domain family member 2 |
|
| chr22_+_23029188 Show fit | 5.58 |
ENST00000390305.2
|
immunoglobulin lambda variable 3-25 |
|
| chr22_+_23229960 Show fit | 5.41 |
ENST00000526893.1
ENST00000532223.2 ENST00000531372.1 |
immunoglobulin lambda-like polypeptide 5 |
|
| chr14_-_106330458 Show fit | 5.20 |
ENST00000461719.1
|
immunoglobulin heavy joining 4 |
|
| chr22_+_22676808 Show fit | 4.37 |
ENST00000390290.2
|
immunoglobulin lambda variable 1-51 |
|
| chr2_-_89513402 Show fit | 4.32 |
ENST00000498435.1
|
immunoglobulin kappa variable 1-27 |
|
| chr8_+_11351494 Show fit | 4.24 |
ENST00000259089.4
|
B lymphoid tyrosine kinase |
|
| chr8_+_11351876 Show fit | 4.04 |
ENST00000529894.1
|
B lymphoid tyrosine kinase |
|
| chr14_-_106453155 Show fit | 4.03 |
ENST00000390594.2
|
immunoglobulin heavy variable 1-2 |
|
| chr14_-_106642049 Show fit | 3.92 |
ENST00000390605.2
|
immunoglobulin heavy variable 1-18 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PPARG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.0 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.1 | 12.8 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 12.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.4 | 9.4 | GO:0048368 | lateral mesoderm development(GO:0048368) |
| 0.2 | 8.3 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 0.4 | 6.2 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 1.7 | 5.2 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
| 0.5 | 5.1 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
| 0.4 | 5.1 | GO:0033629 | negative regulation of cell adhesion mediated by integrin(GO:0033629) |
| 1.2 | 5.0 | GO:1990736 | positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.4 | 21.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 13.9 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.0 | 11.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 2.1 | 10.3 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 0.0 | 7.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 7.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 6.4 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.7 | 6.1 | GO:0044194 | cytolytic granule(GO:0044194) |
| 0.0 | 5.3 | GO:0030667 | secretory granule membrane(GO:0030667) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.8 | GO:0003823 | antigen binding(GO:0003823) |
| 0.3 | 21.7 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 11.4 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.4 | 10.3 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.0 | 9.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.2 | 8.1 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.1 | 5.7 | GO:0005227 | calcium activated cation channel activity(GO:0005227) |
| 1.0 | 5.2 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.0 | 5.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.7 | 5.1 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.0 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 7.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.0 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.1 | 5.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 5.4 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 4.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 4.5 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 4.2 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 3.9 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.2 | 3.4 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 12.2 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 10.9 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 5.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 5.1 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 4.8 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.0 | 4.1 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
| 0.2 | 4.0 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 4.0 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.1 | 3.5 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |