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Illumina Body Map 2: averaged replicates
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Results for PRDM1
Z-value: 2.34
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Transcription factors associated with PRDM1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PRDM1 | hg19_v2_chr6_+_106535455_106535637 | -0.12 | 5.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PRDM1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.4 | GO:0045995 | regulation of embryonic development(GO:0045995) |
| 2.4 | 14.2 | GO:0030421 | defecation(GO:0030421) |
| 0.4 | 11.7 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 2.8 | 8.4 | GO:0035759 | mesangial cell-matrix adhesion(GO:0035759) regulation of dendritic cell dendrite assembly(GO:2000547) |
| 0.0 | 8.4 | GO:0001558 | regulation of cell growth(GO:0001558) |
| 1.6 | 8.1 | GO:1903971 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 0.4 | 8.1 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 0.1 | 7.6 | GO:0008542 | visual learning(GO:0008542) pancreas development(GO:0031016) |
| 1.5 | 7.5 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
| 0.5 | 7.5 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 31.1 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.5 | 25.4 | GO:0005605 | basal lamina(GO:0005605) |
| 1.2 | 8.1 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.1 | 6.2 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.4 | 6.0 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 5.4 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 5.2 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 1.5 | 4.4 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.2 | 3.4 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 3.4 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 29.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 23.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 18.3 | GO:0008201 | heparin binding(GO:0008201) |
| 0.2 | 8.4 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.2 | 8.4 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 1.0 | 8.1 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.9 | 8.1 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.5 | 7.5 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 7.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 7.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.4 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.3 | 22.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 8.1 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 7.7 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 7.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 5.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.1 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 4.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 3.6 | PID AP1 PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 10.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 8.1 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 7.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 6.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 5.6 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 3.6 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.1 | 3.6 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 3.2 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 2.5 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |