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Illumina Body Map 2: averaged replicates

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Results for PROX1

Z-value: 1.73

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Transcription factors associated with PROX1

Gene Symbol Gene ID Gene Info
PROX1
ENSG00000117707.11 prospero homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PROX1hg19_v2_chr1_+_214161272_214161322-0.173.6e-01Click!

Activity profile of PROX1 motif

Sorted Z-values of PROX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_22180536 4.91 ENST00000390424.2
TRAV2
T cell receptor alpha variable 2
chr14_+_22409308 4.89 ENST00000390441.2
TRAV9-2
T cell receptor alpha variable 9-2
chr5_+_156569944 4.81 ENST00000521769.1
ITK
IL2-inducible T-cell kinase
chr14_+_22320634 4.21 ENST00000390435.1
TRAV8-3
T cell receptor alpha variable 8-3
chr12_+_113229737 3.75 ENST00000551052.1
ENST00000415485.3
RPH3A
rabphilin 3A homolog (mouse)
chr12_+_113229543 3.23 ENST00000447659.2
RPH3A
rabphilin 3A homolog (mouse)
chr14_+_22788560 3.18 ENST00000390468.1
TRAV41
T cell receptor alpha variable 41
chr1_-_160832490 2.97 ENST00000322302.7
ENST00000368033.3
CD244
CD244 molecule, natural killer cell receptor 2B4
chr1_-_160832642 2.92 ENST00000368034.4
CD244
CD244 molecule, natural killer cell receptor 2B4
chr12_+_113229452 2.87 ENST00000389385.4
RPH3A
rabphilin 3A homolog (mouse)
chr5_-_156569850 2.83 ENST00000524219.1
HAVCR2
hepatitis A virus cellular receptor 2
chr1_-_160832670 2.62 ENST00000368032.2
CD244
CD244 molecule, natural killer cell receptor 2B4
chr9_+_93564191 2.47 ENST00000375747.1
SYK
spleen tyrosine kinase
chr4_-_170947485 2.44 ENST00000504999.1
MFAP3L
microfibrillar-associated protein 3-like
chr14_+_22458631 2.17 ENST00000390444.1
TRAV16
T cell receptor alpha variable 16
chr1_-_159046617 2.15 ENST00000368130.4
AIM2
absent in melanoma 2
chr5_+_156693159 2.10 ENST00000347377.6
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr19_+_15752088 2.09 ENST00000585846.1
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr3_-_112218205 2.03 ENST00000383680.4
BTLA
B and T lymphocyte associated
chr5_-_157002775 2.02 ENST00000257527.4
ADAM19
ADAM metallopeptidase domain 19
chr10_+_45869652 2.01 ENST00000542434.1
ENST00000374391.2
ALOX5
arachidonate 5-lipoxygenase
chr3_-_112218378 2.00 ENST00000334529.5
BTLA
B and T lymphocyte associated
chr4_-_170947522 1.88 ENST00000361618.3
MFAP3L
microfibrillar-associated protein 3-like
chr6_+_37475109 1.86 ENST00000570443.2
RP1-153P14.8
RP1-153P14.8
chr3_-_130745403 1.83 ENST00000504725.1
ENST00000509060.1
ASTE1
asteroid homolog 1 (Drosophila)
chr1_+_159770292 1.81 ENST00000536257.1
ENST00000321935.6
FCRL6
Fc receptor-like 6
chr4_-_170947446 1.79 ENST00000507601.1
ENST00000512698.1
MFAP3L
microfibrillar-associated protein 3-like
chr1_-_173176452 1.77 ENST00000281834.3
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr11_+_73360024 1.73 ENST00000540431.1
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr17_+_72209653 1.71 ENST00000269346.4
TTYH2
tweety family member 2
chr6_-_25042231 1.70 ENST00000510784.2
FAM65B
family with sequence similarity 65, member B
chr10_+_134258649 1.68 ENST00000392630.3
ENST00000321248.2
C10orf91
chromosome 10 open reading frame 91
chr1_+_207669573 1.64 ENST00000400960.2
ENST00000534202.1
CR1
complement component (3b/4b) receptor 1 (Knops blood group)
chr4_-_170948361 1.61 ENST00000393702.3
MFAP3L
microfibrillar-associated protein 3-like
chr2_-_239140011 1.61 ENST00000409376.1
ENST00000409070.1
ENST00000409942.1
AC016757.3
Protein LOC151174
chrY_+_22918021 1.59 ENST00000288666.5
RPS4Y2
ribosomal protein S4, Y-linked 2
chr19_+_52255261 1.58 ENST00000600258.1
FPR2
formyl peptide receptor 2
chr5_-_157002749 1.56 ENST00000517905.1
ENST00000430702.2
ENST00000394020.1
ADAM19
ADAM metallopeptidase domain 19
chr2_-_152830479 1.48 ENST00000360283.6
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr11_+_73359936 1.47 ENST00000542389.1
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr10_-_121296045 1.43 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr2_+_163175394 1.42 ENST00000446271.1
ENST00000429691.2
GCA
grancalcin, EF-hand calcium binding protein
chr16_+_50300427 1.39 ENST00000394697.2
ENST00000566433.2
ENST00000538642.1
ADCY7
adenylate cyclase 7
chr22_+_24990746 1.37 ENST00000456869.1
ENST00000411974.1
GGT1
gamma-glutamyltransferase 1
chr9_+_125133315 1.31 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr2_-_233877912 1.31 ENST00000264051.3
NGEF
neuronal guanine nucleotide exchange factor
chr15_+_81489213 1.31 ENST00000559383.1
ENST00000394660.2
IL16
interleukin 16
chr19_+_917287 1.30 ENST00000592648.1
ENST00000234371.5
KISS1R
KISS1 receptor
chr3_-_130745571 1.25 ENST00000514044.1
ENST00000264992.3
ASTE1
asteroid homolog 1 (Drosophila)
chr4_-_48683188 1.25 ENST00000505759.1
FRYL
FRY-like
chr11_-_126870655 1.23 ENST00000525144.2
KIRREL3
kin of IRRE like 3 (Drosophila)
chr11_-_111749767 1.21 ENST00000542429.1
FDXACB1
ferredoxin-fold anticodon binding domain containing 1
chr14_+_23013015 1.19 ENST00000390535.2
TRAJ2
T cell receptor alpha joining 2 (non-functional)
chr1_-_109203685 1.18 ENST00000402983.1
ENST00000420055.1
HENMT1
HEN1 methyltransferase homolog 1 (Arabidopsis)
chr7_-_143105941 1.17 ENST00000275815.3
EPHA1
EPH receptor A1
chr9_+_125132803 1.16 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr19_+_35773242 1.15 ENST00000222304.3
HAMP
hepcidin antimicrobial peptide
chr14_+_22782867 1.15 ENST00000390467.3
TRAV40
T cell receptor alpha variable 40
chr1_+_241695670 1.13 ENST00000366557.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr15_-_74726283 1.13 ENST00000543145.2
SEMA7A
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chr5_+_173473662 1.12 ENST00000519717.1
NSG2
Neuron-specific protein family member 2
chr20_-_61885826 1.11 ENST00000370316.3
NKAIN4
Na+/K+ transporting ATPase interacting 4
chr17_+_8869157 1.11 ENST00000585297.1
CTB-41I6.1
CTB-41I6.1
chr19_-_19754404 1.10 ENST00000587205.1
ENST00000445806.2
ENST00000203556.4
GMIP
GEM interacting protein
chr12_+_113229725 1.08 ENST00000551198.1
RPH3A
rabphilin 3A homolog (mouse)
chr6_-_134495992 1.08 ENST00000475719.2
ENST00000367857.5
ENST00000237305.7
SGK1
serum/glucocorticoid regulated kinase 1
chr11_-_131533462 1.08 ENST00000416725.1
AP003039.3
AP003039.3
chr12_+_113229708 1.07 ENST00000550901.1
RPH3A
rabphilin 3A homolog (mouse)
chr17_+_73629500 1.07 ENST00000375215.3
SMIM5
small integral membrane protein 5
chr11_+_61722629 1.06 ENST00000526988.1
BEST1
bestrophin 1
chr1_+_241695424 1.05 ENST00000366558.3
ENST00000366559.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr19_-_19754354 1.05 ENST00000587238.1
GMIP
GEM interacting protein
chr12_+_121078355 1.04 ENST00000316803.3
CABP1
calcium binding protein 1
chr2_+_28718921 1.03 ENST00000327757.5
ENST00000422425.2
ENST00000404858.1
PLB1
phospholipase B1
chr12_+_10331605 1.02 ENST00000298530.3
TMEM52B
transmembrane protein 52B
chr6_-_35992270 1.00 ENST00000394602.2
ENST00000355574.2
SLC26A8
solute carrier family 26 (anion exchanger), member 8
chr4_-_170947565 0.99 ENST00000506764.1
MFAP3L
microfibrillar-associated protein 3-like
chr1_-_109203648 0.99 ENST00000370031.1
HENMT1
HEN1 methyltransferase homolog 1 (Arabidopsis)
chr3_-_33138286 0.99 ENST00000416695.2
ENST00000342462.4
ENST00000399402.3
TMPPE
GLB1
transmembrane protein with metallophosphoesterase domain
galactosidase, beta 1
chr11_-_111749878 0.92 ENST00000260257.4
FDXACB1
ferredoxin-fold anticodon binding domain containing 1
chr4_-_38666430 0.91 ENST00000436901.1
AC021860.1
Uncharacterized protein
chr21_-_46961716 0.91 ENST00000427839.1
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr2_-_54087066 0.91 ENST00000394705.2
ENST00000352846.3
ENST00000406625.2
GPR75
GPR75-ASB3
ASB3
G protein-coupled receptor 75
GPR75-ASB3 readthrough
Ankyrin repeat and SOCS box protein 3
chr9_+_132096166 0.90 ENST00000436710.1
RP11-65J3.1
RP11-65J3.1
chr10_+_16478942 0.90 ENST00000535784.2
ENST00000423462.2
ENST00000378000.1
PTER
phosphotriesterase related
chr9_-_130497565 0.89 ENST00000336067.6
ENST00000373281.5
ENST00000373284.5
ENST00000458505.3
TOR2A
torsin family 2, member A
chr1_-_225616515 0.87 ENST00000338179.2
ENST00000425080.1
LBR
lamin B receptor
chr11_-_126870683 0.87 ENST00000525704.2
KIRREL3
kin of IRRE like 3 (Drosophila)
chr22_+_27042387 0.86 ENST00000421867.1
MIAT
myocardial infarction associated transcript (non-protein coding)
chr14_+_73603126 0.86 ENST00000557356.1
ENST00000556864.1
ENST00000556533.1
ENST00000556951.1
ENST00000557293.1
ENST00000553719.1
ENST00000553599.1
ENST00000556011.1
ENST00000394157.3
ENST00000357710.4
ENST00000324501.5
ENST00000560005.2
ENST00000555254.1
ENST00000261970.3
ENST00000344094.3
ENST00000554131.1
ENST00000557037.1
PSEN1
presenilin 1
chr21_-_16125773 0.85 ENST00000454128.2
AF127936.3
AF127936.3
chr14_-_50559361 0.85 ENST00000305273.1
C14orf183
chromosome 14 open reading frame 183
chr7_+_18126557 0.85 ENST00000417496.2
HDAC9
histone deacetylase 9
chr3_+_186915274 0.84 ENST00000312295.4
RTP1
receptor (chemosensory) transporter protein 1
chr3_-_33138592 0.84 ENST00000415454.1
GLB1
galactosidase, beta 1
chr2_+_131862900 0.84 ENST00000438882.2
ENST00000538982.1
ENST00000404460.1
PLEKHB2
pleckstrin homology domain containing, family B (evectins) member 2
chr7_+_48128316 0.83 ENST00000341253.4
UPP1
uridine phosphorylase 1
chr12_+_113229337 0.83 ENST00000552667.1
RPH3A
rabphilin 3A homolog (mouse)
chr3_-_33138624 0.81 ENST00000445488.2
ENST00000307377.8
ENST00000440656.1
ENST00000436768.1
ENST00000307363.5
GLB1
galactosidase, beta 1
chr4_+_2819883 0.77 ENST00000511747.1
ENST00000503393.2
SH3BP2
SH3-domain binding protein 2
chr11_+_92085262 0.76 ENST00000298047.6
ENST00000409404.2
ENST00000541502.1
FAT3
FAT atypical cadherin 3
chr14_+_78266408 0.76 ENST00000238561.5
ADCK1
aarF domain containing kinase 1
chr1_+_179262905 0.76 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
SOAT1
sterol O-acyltransferase 1
chr2_+_131862872 0.76 ENST00000439822.2
PLEKHB2
pleckstrin homology domain containing, family B (evectins) member 2
chr7_+_48128194 0.75 ENST00000416681.1
ENST00000331803.4
ENST00000432131.1
UPP1
uridine phosphorylase 1
chr8_-_116681686 0.74 ENST00000519815.1
TRPS1
trichorhinophalangeal syndrome I
chr8_-_19615382 0.74 ENST00000544602.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr1_+_95975672 0.74 ENST00000440116.2
ENST00000456933.1
RP11-286B14.1
RP11-286B14.1
chr11_+_1874200 0.73 ENST00000311604.3
LSP1
lymphocyte-specific protein 1
chr5_-_180688105 0.72 ENST00000327767.4
TRIM52
tripartite motif containing 52
chr4_+_26862400 0.72 ENST00000467011.1
ENST00000412829.2
STIM2
stromal interaction molecule 2
chr3_-_18487057 0.72 ENST00000415069.1
SATB1
SATB homeobox 1
chr14_+_45605127 0.71 ENST00000556036.1
ENST00000267430.5
FANCM
Fanconi anemia, complementation group M
chr7_+_64254793 0.70 ENST00000494380.1
ENST00000440155.2
ENST00000440598.1
ENST00000437743.1
ZNF138
zinc finger protein 138
chr11_-_83436446 0.70 ENST00000529399.1
DLG2
discs, large homolog 2 (Drosophila)
chr17_+_41994576 0.68 ENST00000588043.2
FAM215A
family with sequence similarity 215, member A (non-protein coding)
chr12_-_11091862 0.68 ENST00000537503.1
TAS2R14
taste receptor, type 2, member 14
chr2_-_239140276 0.68 ENST00000334973.4
AC016757.3
Protein LOC151174
chr2_+_241499719 0.67 ENST00000405954.1
DUSP28
dual specificity phosphatase 28
chr1_+_179263308 0.67 ENST00000426956.1
SOAT1
sterol O-acyltransferase 1
chr11_-_46408107 0.67 ENST00000433765.2
CHRM4
cholinergic receptor, muscarinic 4
chr11_+_61522844 0.67 ENST00000265460.5
MYRF
myelin regulatory factor
chr1_-_211307404 0.67 ENST00000367007.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr7_+_66093851 0.67 ENST00000275532.3
KCTD7
potassium channel tetramerization domain containing 7
chr10_-_50970382 0.63 ENST00000419399.1
ENST00000432695.1
OGDHL
oxoglutarate dehydrogenase-like
chr5_+_162930114 0.63 ENST00000280969.5
MAT2B
methionine adenosyltransferase II, beta
chr8_-_19615538 0.62 ENST00000517494.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr19_+_53073526 0.62 ENST00000596514.1
ENST00000391785.3
ENST00000301093.2
ZNF701
zinc finger protein 701
chr5_+_175490540 0.61 ENST00000515817.1
FAM153B
family with sequence similarity 153, member B
chr16_+_12070567 0.61 ENST00000566228.1
SNX29
sorting nexin 29
chrX_+_118602363 0.60 ENST00000317881.8
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr7_+_66093908 0.60 ENST00000443322.1
ENST00000449064.1
KCTD7
potassium channel tetramerization domain containing 7
chr22_-_50050986 0.60 ENST00000405854.1
C22orf34
chromosome 22 open reading frame 34
chr17_+_16593539 0.60 ENST00000340621.5
ENST00000399273.1
ENST00000443444.2
ENST00000360524.8
ENST00000456009.1
CCDC144A
coiled-coil domain containing 144A
chr10_-_98945264 0.60 ENST00000314867.5
SLIT1
slit homolog 1 (Drosophila)
chr10_-_50970322 0.58 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr9_+_131267052 0.57 ENST00000539582.1
GLE1
GLE1 RNA export mediator
chr7_+_64254766 0.57 ENST00000307355.7
ENST00000359735.3
ZNF138
zinc finger protein 138
chr3_+_190105909 0.57 ENST00000456423.1
CLDN16
claudin 16
chr3_+_9839335 0.57 ENST00000453882.1
ARPC4-TTLL3
ARPC4-TTLL3 readthrough
chr19_-_9546227 0.56 ENST00000361451.2
ENST00000361151.1
ZNF266
zinc finger protein 266
chr2_-_89310012 0.56 ENST00000493819.1
IGKV1-9
immunoglobulin kappa variable 1-9
chr7_-_102257139 0.55 ENST00000521076.1
ENST00000462172.1
ENST00000522801.1
ENST00000449970.2
ENST00000262940.7
RASA4
RAS p21 protein activator 4
chr14_+_45605157 0.54 ENST00000542564.2
FANCM
Fanconi anemia, complementation group M
chr12_-_122240792 0.54 ENST00000545885.1
ENST00000542933.1
ENST00000428029.2
ENST00000541694.1
ENST00000536662.1
ENST00000535643.1
ENST00000541657.1
AC084018.1
RHOF
AC084018.1
ras homolog family member F (in filopodia)
chr6_+_132455526 0.53 ENST00000443303.1
LINC01013
long intergenic non-protein coding RNA 1013
chr19_+_23945768 0.53 ENST00000486528.1
ENST00000496398.1
RPSAP58
ribosomal protein SA pseudogene 58
chr1_-_179457805 0.53 ENST00000600581.1
AL160286.1
Uncharacterized protein
chr6_-_8102279 0.53 ENST00000488226.2
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
chr5_-_22853429 0.52 ENST00000504376.2
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr1_+_10459111 0.52 ENST00000541529.1
ENST00000270776.8
ENST00000483936.1
ENST00000538557.1
PGD
phosphogluconate dehydrogenase
chr10_+_71075516 0.52 ENST00000436817.1
HK1
hexokinase 1
chr4_-_128887069 0.51 ENST00000541133.1
ENST00000296468.3
ENST00000513559.1
MFSD8
major facilitator superfamily domain containing 8
chr12_-_58240470 0.50 ENST00000548823.1
ENST00000398073.2
CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr11_-_83435965 0.50 ENST00000434967.1
ENST00000530800.1
DLG2
discs, large homolog 2 (Drosophila)
chr8_-_19615435 0.50 ENST00000523262.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr7_-_91509986 0.50 ENST00000456229.1
ENST00000442961.1
ENST00000406735.2
ENST00000419292.1
ENST00000351870.3
MTERF
mitochondrial transcription termination factor
chr4_+_26862431 0.50 ENST00000465503.1
STIM2
stromal interaction molecule 2
chr6_-_107235287 0.50 ENST00000436659.1
ENST00000428750.1
ENST00000427903.1
RP1-60O19.1
RP1-60O19.1
chr19_-_9546177 0.49 ENST00000592292.1
ENST00000588221.1
ZNF266
zinc finger protein 266
chr19_-_57335682 0.49 ENST00000593931.1
ZIM2
zinc finger, imprinted 2
chr1_-_151431674 0.49 ENST00000531094.1
POGZ
pogo transposable element with ZNF domain
chr2_+_139259324 0.49 ENST00000280098.4
SPOPL
speckle-type POZ protein-like
chr21_-_16126181 0.48 ENST00000455253.2
AF127936.3
AF127936.3
chr7_-_102158157 0.48 ENST00000541662.1
ENST00000306682.6
ENST00000465829.1
RASA4B
RAS p21 protein activator 4B
chr4_+_128886532 0.48 ENST00000444616.1
ENST00000388795.5
C4orf29
chromosome 4 open reading frame 29
chr4_+_26862313 0.48 ENST00000467087.1
ENST00000382009.3
ENST00000237364.5
STIM2
stromal interaction molecule 2
chrX_+_150565038 0.48 ENST00000370361.1
VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr5_-_72861175 0.48 ENST00000504641.1
ANKRA2
ankyrin repeat, family A (RFXANK-like), 2
chr20_+_56964253 0.47 ENST00000395802.3
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr2_-_225434538 0.47 ENST00000409096.1
CUL3
cullin 3
chr5_-_156569754 0.47 ENST00000420343.1
MED7
mediator complex subunit 7
chr3_-_11888246 0.47 ENST00000455809.1
ENST00000444133.2
ENST00000273037.5
TAMM41
TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae)
chrX_+_57618269 0.47 ENST00000374888.1
ZXDB
zinc finger, X-linked, duplicated B
chr8_-_135652051 0.46 ENST00000522257.1
ZFAT
zinc finger and AT hook domain containing
chr18_-_2571210 0.46 ENST00000577166.1
METTL4
methyltransferase like 4
chr9_+_131266963 0.45 ENST00000309971.4
ENST00000372770.4
GLE1
GLE1 RNA export mediator
chr10_+_71075552 0.45 ENST00000298649.3
HK1
hexokinase 1
chr18_+_60190226 0.45 ENST00000269499.5
ZCCHC2
zinc finger, CCHC domain containing 2
chr11_+_28131821 0.44 ENST00000379199.2
ENST00000303459.6
METTL15
methyltransferase like 15
chr16_+_29817399 0.44 ENST00000545521.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr5_-_177210399 0.44 ENST00000510276.1
FAM153A
family with sequence similarity 153, member A
chr18_-_21166841 0.44 ENST00000269228.5
NPC1
Niemann-Pick disease, type C1
chr3_-_47555167 0.44 ENST00000296149.4
ELP6
elongator acetyltransferase complex subunit 6
chr19_+_4007644 0.43 ENST00000262971.2
PIAS4
protein inhibitor of activated STAT, 4
chr6_-_28226984 0.43 ENST00000423974.2
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr5_+_145583156 0.43 ENST00000265271.5
RBM27
RNA binding motif protein 27
chr11_+_46740730 0.42 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
F2
coagulation factor II (thrombin)
chr1_+_161719552 0.42 ENST00000367943.4
DUSP12
dual specificity phosphatase 12
chr1_+_179050512 0.42 ENST00000367627.3
TOR3A
torsin family 3, member A
chr3_-_197024965 0.42 ENST00000392382.2
DLG1
discs, large homolog 1 (Drosophila)
chr2_-_98280383 0.42 ENST00000289228.5
ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr14_-_36645674 0.41 ENST00000556013.2
PTCSC3
papillary thyroid carcinoma susceptibility candidate 3 (non-protein coding)
chr5_+_145583107 0.41 ENST00000506502.1
RBM27
RNA binding motif protein 27
chr20_-_7921090 0.40 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr6_+_132455118 0.40 ENST00000458028.1
LINC01013
long intergenic non-protein coding RNA 1013
chr15_+_43809797 0.40 ENST00000399453.1
ENST00000300231.5
MAP1A
microtubule-associated protein 1A
chr2_+_232826394 0.40 ENST00000409401.3
ENST00000441279.1
DIS3L2
DIS3 mitotic control homolog (S. cerevisiae)-like 2
chr7_+_92158083 0.39 ENST00000265732.5
ENST00000481551.1
ENST00000496410.1
RBM48
RNA binding motif protein 48
chr16_-_23607598 0.38 ENST00000562133.1
ENST00000570319.1
ENST00000007516.3
NDUFAB1
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of PROX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.5 GO:0071613 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
0.9 2.8 GO:0002519 natural killer cell tolerance induction(GO:0002519) regulation of tolerance induction dependent upon immune response(GO:0002652) negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859)
0.7 2.1 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.7 2.6 GO:0051413 response to cortisone(GO:0051413)
0.6 2.5 GO:0045401 response to molecule of fungal origin(GO:0002238) regulation of interleukin-3 production(GO:0032672) positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) cellular response to molecule of fungal origin(GO:0071226)
0.6 1.8 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.5 1.6 GO:0030451 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
0.4 1.6 GO:0006218 uridine catabolic process(GO:0006218)
0.4 1.2 GO:1903413 cellular response to bile acid(GO:1903413) response to iron ion starvation(GO:1990641)
0.3 2.2 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.3 2.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.3 2.1 GO:0036101 leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569)
0.3 4.8 GO:0001865 NK T cell differentiation(GO:0001865)
0.2 1.4 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.2 1.9 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.2 0.9 GO:0098838 reduced folate transmembrane transport(GO:0098838)
0.2 2.0 GO:2001300 lipoxin metabolic process(GO:2001300)
0.2 2.2 GO:0070269 pyroptosis(GO:0070269)
0.2 2.1 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.2 0.6 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.2 1.7 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 0.9 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563)
0.1 12.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 0.5 GO:0019521 aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521)
0.1 0.4 GO:0045643 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.1 0.6 GO:0015853 adenine transport(GO:0015853)
0.1 2.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.6 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.1 0.1 GO:0000022 mitotic spindle elongation(GO:0000022)
0.1 1.6 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.3 GO:0071139 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
0.1 0.5 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.1 1.3 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.1 2.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 1.0 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.1 0.3 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.1 1.0 GO:2000344 positive regulation of acrosome reaction(GO:2000344)
0.1 0.4 GO:1900738 cytolysis in other organism involved in symbiotic interaction(GO:0051801) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.1 1.1 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.2 GO:1901143 insulin catabolic process(GO:1901143)
0.1 2.2 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 0.3 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.1 1.4 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 0.1 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
0.1 0.3 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.1 0.7 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 1.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 0.2 GO:0035602 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604)
0.1 1.0 GO:0006449 regulation of translational termination(GO:0006449)
0.1 1.2 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 0.4 GO:1902231 positive regulation of keratinocyte apoptotic process(GO:1902174) positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1 0.7 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.4 GO:0033133 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.1 0.6 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 0.2 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.1 0.2 GO:0036292 DNA rewinding(GO:0036292)
0.1 1.2 GO:0090527 actin filament reorganization(GO:0090527)
0.1 12.2 GO:0002377 immunoglobulin production(GO:0002377)
0.1 1.4 GO:0071361 cellular response to ethanol(GO:0071361)
0.1 3.6 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 0.4 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.1 0.4 GO:0070475 rRNA base methylation(GO:0070475)
0.1 0.3 GO:0034184 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.1 1.0 GO:0019532 oxalate transport(GO:0019532)
0.1 1.3 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 0.6 GO:0018094 protein polyglycylation(GO:0018094)
0.1 0.4 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 0.8 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.4 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.4 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 1.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.2 GO:0015692 lead ion transport(GO:0015692)
0.0 0.9 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.5 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.6 GO:0000050 urea cycle(GO:0000050)
0.0 3.2 GO:0007602 phototransduction(GO:0007602)
0.0 1.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 4.9 GO:0031295 T cell costimulation(GO:0031295)
0.0 2.6 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.5 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.7 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.5 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.5 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.1 GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.0 0.4 GO:0009249 protein lipoylation(GO:0009249)
0.0 1.2 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.3 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.0 0.1 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 1.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:0043983 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) histone H4-K12 acetylation(GO:0043983)
0.0 1.2 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.6 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 1.5 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.3 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.4 GO:0032025 response to cobalt ion(GO:0032025)
0.0 0.3 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.9 GO:0030855 epithelial cell differentiation(GO:0030855)
0.0 0.5 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0 0.1 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.0 0.5 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.0 0.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.2 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.0 0.5 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.4 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0 1.7 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.1 GO:0043504 mitochondrial DNA repair(GO:0043504)
0.0 0.1 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.1 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.4 1.2 GO:0071821 FANCM-MHF complex(GO:0071821)
0.4 2.5 GO:0019815 B cell receptor complex(GO:0019815)
0.2 2.2 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.2 0.6 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.1 1.0 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 2.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 1.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.6 GO:0071817 MMXD complex(GO:0071817)
0.1 0.4 GO:0043293 apoptosome(GO:0043293)
0.1 0.9 GO:0035253 ciliary rootlet(GO:0035253) gamma-secretase complex(GO:0070765)
0.1 2.2 GO:0043186 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 10.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.2 GO:0045179 apical cortex(GO:0045179)
0.1 0.5 GO:1990393 3M complex(GO:1990393)
0.1 0.8 GO:0070652 HAUS complex(GO:0070652)
0.0 0.5 GO:0005827 polar microtubule(GO:0005827)
0.0 0.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 1.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.3 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.6 GO:0097025 lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 1.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 1.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0097361 CIA complex(GO:0097361)
0.0 0.3 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 2.0 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 1.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 3.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 3.2 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 0.4 GO:0005869 dynactin complex(GO:0005869)
0.0 2.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.1 GO:0031592 centrosomal corona(GO:0031592)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.7 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 0.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.0 GO:0097228 sperm principal piece(GO:0097228)
0.0 10.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.1 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.5 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.1 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.0 2.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 3.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 1.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.1 GO:0000243 commitment complex(GO:0000243)
0.0 0.2 GO:0031597 cytosolic proteasome complex(GO:0031597)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0052870 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.6 12.8 GO:0008430 selenium binding(GO:0008430)
0.5 1.6 GO:0001861 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.5 2.4 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.5 1.4 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.4 2.6 GO:0016936 galactoside binding(GO:0016936)
0.3 1.6 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.3 2.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.3 0.9 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.3 1.9 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.3 1.0 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.2 0.9 GO:0008518 reduced folate carrier activity(GO:0008518)
0.2 1.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.2 8.5 GO:0042288 MHC class I protein binding(GO:0042288)
0.2 1.6 GO:0005124 N-formyl peptide receptor activity(GO:0004982) scavenger receptor binding(GO:0005124)
0.2 1.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.2 0.5 GO:0033149 FFAT motif binding(GO:0033149)
0.2 0.6 GO:0005471 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.1 0.4 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 0.9 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 2.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.4 GO:0052853 (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
0.1 0.4 GO:0031177 phosphopantetheine binding(GO:0031177)
0.1 0.4 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.1 2.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 0.8 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 0.5 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.1 1.0 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.5 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.1 1.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.5 GO:0031208 POZ domain binding(GO:0031208)
0.1 1.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 1.1 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 0.7 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.2 GO:0031626 beta-endorphin binding(GO:0031626)
0.1 0.5 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.1 1.4 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 0.7 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 0.4 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.1 0.6 GO:0048495 Roundabout binding(GO:0048495)
0.1 2.2 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 1.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 0.3 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 1.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.6 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.1 2.0 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.4 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.5 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.0 0.3 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.6 GO:0097016 L27 domain binding(GO:0097016)
0.0 1.3 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 4.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.2 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.0 1.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.3 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.0 1.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.9 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.5 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.2 GO:0015639 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.1 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.0 0.3 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.1 GO:0036033 mediator complex binding(GO:0036033)
0.0 1.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.3 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.7 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 1.0 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.2 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 1.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.1 GO:0001026 TFIIIB-type transcription factor activity(GO:0001026)
0.0 0.4 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.8 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.3 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 1.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.4 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 1.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.1 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 0.2 GO:1904047 histone methyltransferase activity (H3-K9 specific)(GO:0046974) S-adenosyl-L-methionine binding(GO:1904047)
0.0 0.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 1.6 GO:0019843 rRNA binding(GO:0019843)
0.0 0.8 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 4.4 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.2 GO:0036310 annealing helicase activity(GO:0036310)
0.0 1.7 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 5.1 GO:0004518 nuclease activity(GO:0004518)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.5 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.0 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670)
0.0 0.1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0 0.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.3 GO:0017127 cholesterol transporter activity(GO:0017127)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 2.5 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 8.4 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 1.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 2.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.9 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.9 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.5 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 1.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.3 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.5 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 2.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.6 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 2.1 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 4.8 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 1.4 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.2 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 4.9 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.1 2.5 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 0.6 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 1.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.9 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 1.6 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.9 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 4.5 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.4 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.6 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.3 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.2 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling