Motif ID: PROX1

Z-value: 1.735


Transcription factors associated with PROX1:

Gene SymbolEntrez IDGene Name
PROX1 ENSG00000117707.11 PROX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PROX1hg19_v2_chr1_+_214161272_214161322-0.173.6e-01Click!


Activity profile for motif PROX1.

activity profile for motif PROX1


Sorted Z-values histogram for motif PROX1

Sorted Z-values for motif PROX1



Network of associatons between targets according to the STRING database.



First level regulatory network of PROX1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_22180536 4.911 ENST00000390424.2
TRAV2
T cell receptor alpha variable 2
chr14_+_22409308 4.890 ENST00000390441.2
TRAV9-2
T cell receptor alpha variable 9-2
chr5_+_156569944 4.810 ENST00000521769.1
ITK
IL2-inducible T-cell kinase
chr14_+_22320634 4.211 ENST00000390435.1
TRAV8-3
T cell receptor alpha variable 8-3
chr12_+_113229737 3.753 ENST00000551052.1
ENST00000415485.3
RPH3A

rabphilin 3A homolog (mouse)

chr12_+_113229543 3.230 ENST00000447659.2
RPH3A
rabphilin 3A homolog (mouse)
chr14_+_22788560 3.184 ENST00000390468.1
TRAV41
T cell receptor alpha variable 41
chr1_-_160832490 2.969 ENST00000322302.7
ENST00000368033.3
CD244

CD244 molecule, natural killer cell receptor 2B4

chr1_-_160832642 2.924 ENST00000368034.4
CD244
CD244 molecule, natural killer cell receptor 2B4
chr12_+_113229452 2.867 ENST00000389385.4
RPH3A
rabphilin 3A homolog (mouse)
chr5_-_156569850 2.832 ENST00000524219.1
HAVCR2
hepatitis A virus cellular receptor 2
chr1_-_160832670 2.623 ENST00000368032.2
CD244
CD244 molecule, natural killer cell receptor 2B4
chr9_+_93564191 2.468 ENST00000375747.1
SYK
spleen tyrosine kinase
chr4_-_170947485 2.443 ENST00000504999.1
MFAP3L
microfibrillar-associated protein 3-like
chr14_+_22458631 2.172 ENST00000390444.1
TRAV16
T cell receptor alpha variable 16
chr1_-_159046617 2.153 ENST00000368130.4
AIM2
absent in melanoma 2
chr5_+_156693159 2.097 ENST00000347377.6
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr19_+_15752088 2.094 ENST00000585846.1
CYP4F3
cytochrome P450, family 4, subfamily F, polypeptide 3
chr3_-_112218205 2.026 ENST00000383680.4
BTLA
B and T lymphocyte associated
chr5_-_157002775 2.016 ENST00000257527.4
ADAM19
ADAM metallopeptidase domain 19
chr10_+_45869652 2.008 ENST00000542434.1
ENST00000374391.2
ALOX5

arachidonate 5-lipoxygenase

chr3_-_112218378 2.004 ENST00000334529.5
BTLA
B and T lymphocyte associated
chr4_-_170947522 1.878 ENST00000361618.3
MFAP3L
microfibrillar-associated protein 3-like
chr6_+_37475109 1.858 ENST00000570443.2
RP1-153P14.8
RP1-153P14.8
chr3_-_130745403 1.830 ENST00000504725.1
ENST00000509060.1
ASTE1

asteroid homolog 1 (Drosophila)

chr1_+_159770292 1.813 ENST00000536257.1
ENST00000321935.6
FCRL6

Fc receptor-like 6

chr4_-_170947446 1.795 ENST00000507601.1
ENST00000512698.1
MFAP3L

microfibrillar-associated protein 3-like

chr1_-_173176452 1.767 ENST00000281834.3
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr11_+_73360024 1.734 ENST00000540431.1
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr17_+_72209653 1.710 ENST00000269346.4
TTYH2
tweety family member 2
chr6_-_25042231 1.696 ENST00000510784.2
FAM65B
family with sequence similarity 65, member B
chr10_+_134258649 1.682 ENST00000392630.3
ENST00000321248.2
C10orf91

chromosome 10 open reading frame 91

chr1_+_207669573 1.636 ENST00000400960.2
ENST00000534202.1
CR1

complement component (3b/4b) receptor 1 (Knops blood group)

chr4_-_170948361 1.611 ENST00000393702.3
MFAP3L
microfibrillar-associated protein 3-like
chr2_-_239140011 1.609 ENST00000409376.1
ENST00000409070.1
ENST00000409942.1
AC016757.3


Protein LOC151174


chrY_+_22918021 1.586 ENST00000288666.5
RPS4Y2
ribosomal protein S4, Y-linked 2
chr19_+_52255261 1.577 ENST00000600258.1
FPR2
formyl peptide receptor 2
chr5_-_157002749 1.564 ENST00000517905.1
ENST00000430702.2
ENST00000394020.1
ADAM19


ADAM metallopeptidase domain 19


chr2_-_152830479 1.483 ENST00000360283.6
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr11_+_73359936 1.468 ENST00000542389.1
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr10_-_121296045 1.432 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr2_+_163175394 1.421 ENST00000446271.1
ENST00000429691.2
GCA

grancalcin, EF-hand calcium binding protein

chr16_+_50300427 1.395 ENST00000394697.2
ENST00000566433.2
ENST00000538642.1
ADCY7


adenylate cyclase 7


chr22_+_24990746 1.368 ENST00000456869.1
ENST00000411974.1
GGT1

gamma-glutamyltransferase 1

chr9_+_125133315 1.314 ENST00000223423.4
ENST00000362012.2
PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr2_-_233877912 1.313 ENST00000264051.3
NGEF
neuronal guanine nucleotide exchange factor
chr15_+_81489213 1.307 ENST00000559383.1
ENST00000394660.2
IL16

interleukin 16

chr19_+_917287 1.301 ENST00000592648.1
ENST00000234371.5
KISS1R

KISS1 receptor

chr3_-_130745571 1.251 ENST00000514044.1
ENST00000264992.3
ASTE1

asteroid homolog 1 (Drosophila)

chr4_-_48683188 1.250 ENST00000505759.1
FRYL
FRY-like
chr11_-_126870655 1.230 ENST00000525144.2
KIRREL3
kin of IRRE like 3 (Drosophila)
chr11_-_111749767 1.206 ENST00000542429.1
FDXACB1
ferredoxin-fold anticodon binding domain containing 1
chr14_+_23013015 1.194 ENST00000390535.2
TRAJ2
T cell receptor alpha joining 2 (non-functional)
chr1_-_109203685 1.176 ENST00000402983.1
ENST00000420055.1
HENMT1

HEN1 methyltransferase homolog 1 (Arabidopsis)

chr7_-_143105941 1.165 ENST00000275815.3
EPHA1
EPH receptor A1
chr9_+_125132803 1.159 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr19_+_35773242 1.155 ENST00000222304.3
HAMP
hepcidin antimicrobial peptide
chr14_+_22782867 1.154 ENST00000390467.3
TRAV40
T cell receptor alpha variable 40
chr1_+_241695670 1.131 ENST00000366557.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr15_-_74726283 1.131 ENST00000543145.2
SEMA7A
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chr5_+_173473662 1.119 ENST00000519717.1
NSG2
Neuron-specific protein family member 2
chr20_-_61885826 1.107 ENST00000370316.3
NKAIN4
Na+/K+ transporting ATPase interacting 4
chr17_+_8869157 1.107 ENST00000585297.1
CTB-41I6.1
CTB-41I6.1
chr19_-_19754404 1.103 ENST00000587205.1
ENST00000445806.2
ENST00000203556.4
GMIP


GEM interacting protein


chr12_+_113229725 1.084 ENST00000551198.1
RPH3A
rabphilin 3A homolog (mouse)
chr6_-_134495992 1.076 ENST00000475719.2
ENST00000367857.5
ENST00000237305.7
SGK1


serum/glucocorticoid regulated kinase 1


chr11_-_131533462 1.075 ENST00000416725.1
AP003039.3
AP003039.3
chr12_+_113229708 1.071 ENST00000550901.1
RPH3A
rabphilin 3A homolog (mouse)
chr17_+_73629500 1.070 ENST00000375215.3
SMIM5
small integral membrane protein 5
chr11_+_61722629 1.063 ENST00000526988.1
BEST1
bestrophin 1
chr1_+_241695424 1.055 ENST00000366558.3
ENST00000366559.4
KMO

kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)

chr19_-_19754354 1.051 ENST00000587238.1
GMIP
GEM interacting protein
chr12_+_121078355 1.045 ENST00000316803.3
CABP1
calcium binding protein 1
chr2_+_28718921 1.034 ENST00000327757.5
ENST00000422425.2
ENST00000404858.1
PLB1


phospholipase B1


chr12_+_10331605 1.023 ENST00000298530.3
TMEM52B
transmembrane protein 52B
chr6_-_35992270 1.000 ENST00000394602.2
ENST00000355574.2
SLC26A8

solute carrier family 26 (anion exchanger), member 8

chr4_-_170947565 0.990 ENST00000506764.1
MFAP3L
microfibrillar-associated protein 3-like
chr1_-_109203648 0.988 ENST00000370031.1
HENMT1
HEN1 methyltransferase homolog 1 (Arabidopsis)
chr3_-_33138286 0.987 ENST00000399402.3
ENST00000416695.2
ENST00000342462.4
GLB1
TMPPE

galactosidase, beta 1
transmembrane protein with metallophosphoesterase domain

chr11_-_111749878 0.921 ENST00000260257.4
FDXACB1
ferredoxin-fold anticodon binding domain containing 1
chr4_-_38666430 0.911 ENST00000436901.1
AC021860.1
Uncharacterized protein
chr21_-_46961716 0.911 ENST00000427839.1
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr2_-_54087066 0.908 ENST00000352846.3
ENST00000394705.2
ENST00000406625.2
GPR75-ASB3
GPR75
ASB3
GPR75-ASB3 readthrough
G protein-coupled receptor 75
Ankyrin repeat and SOCS box protein 3
chr9_+_132096166 0.897 ENST00000436710.1
RP11-65J3.1
RP11-65J3.1
chr10_+_16478942 0.897 ENST00000535784.2
ENST00000423462.2
ENST00000378000.1
PTER


phosphotriesterase related


chr9_-_130497565 0.889 ENST00000336067.6
ENST00000373281.5
ENST00000373284.5
ENST00000458505.3
TOR2A



torsin family 2, member A



chr1_-_225616515 0.874 ENST00000338179.2
ENST00000425080.1
LBR

lamin B receptor

chr11_-_126870683 0.865 ENST00000525704.2
KIRREL3
kin of IRRE like 3 (Drosophila)
chr22_+_27042387 0.860 ENST00000421867.1
MIAT
myocardial infarction associated transcript (non-protein coding)
chr14_+_73603126 0.856 ENST00000557356.1
ENST00000556864.1
ENST00000556533.1
ENST00000556951.1
ENST00000557293.1
ENST00000553719.1
ENST00000553599.1
ENST00000556011.1
ENST00000394157.3
ENST00000357710.4
ENST00000324501.5
ENST00000560005.2
ENST00000555254.1
ENST00000261970.3
ENST00000344094.3
ENST00000554131.1
ENST00000557037.1
PSEN1
















presenilin 1
















chr21_-_16125773 0.855 ENST00000454128.2
AF127936.3
AF127936.3
chr14_-_50559361 0.850 ENST00000305273.1
C14orf183
chromosome 14 open reading frame 183
chr7_+_18126557 0.848 ENST00000417496.2
HDAC9
histone deacetylase 9
chr3_+_186915274 0.845 ENST00000312295.4
RTP1
receptor (chemosensory) transporter protein 1
chr3_-_33138592 0.843 ENST00000415454.1
GLB1
galactosidase, beta 1
chr2_+_131862900 0.843 ENST00000438882.2
ENST00000538982.1
ENST00000404460.1
PLEKHB2


pleckstrin homology domain containing, family B (evectins) member 2


chr7_+_48128316 0.832 ENST00000341253.4
UPP1
uridine phosphorylase 1
chr12_+_113229337 0.830 ENST00000552667.1
RPH3A
rabphilin 3A homolog (mouse)
chr3_-_33138624 0.815 ENST00000445488.2
ENST00000307377.8
ENST00000440656.1
ENST00000436768.1
ENST00000307363.5
GLB1




galactosidase, beta 1




chr4_+_2819883 0.770 ENST00000511747.1
ENST00000503393.2
SH3BP2

SH3-domain binding protein 2

chr11_+_92085262 0.761 ENST00000298047.6
ENST00000409404.2
ENST00000541502.1
FAT3


FAT atypical cadherin 3


chr14_+_78266408 0.760 ENST00000238561.5
ADCK1
aarF domain containing kinase 1
chr1_+_179262905 0.757 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
SOAT1



sterol O-acyltransferase 1



chr2_+_131862872 0.757 ENST00000439822.2
PLEKHB2
pleckstrin homology domain containing, family B (evectins) member 2
chr7_+_48128194 0.754 ENST00000416681.1
ENST00000331803.4
ENST00000432131.1
UPP1


uridine phosphorylase 1


chr8_-_116681686 0.744 ENST00000519815.1
TRPS1
trichorhinophalangeal syndrome I
chr8_-_19615382 0.742 ENST00000544602.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr1_+_95975672 0.736 ENST00000440116.2
ENST00000456933.1
RP11-286B14.1

RP11-286B14.1

chr11_+_1874200 0.730 ENST00000311604.3
LSP1
lymphocyte-specific protein 1
chr5_-_180688105 0.724 ENST00000327767.4
TRIM52
tripartite motif containing 52
chr4_+_26862400 0.721 ENST00000467011.1
ENST00000412829.2
STIM2

stromal interaction molecule 2

chr3_-_18487057 0.719 ENST00000415069.1
SATB1
SATB homeobox 1
chr14_+_45605127 0.705 ENST00000556036.1
ENST00000267430.5
FANCM

Fanconi anemia, complementation group M

chr7_+_64254793 0.704 ENST00000494380.1
ENST00000440155.2
ENST00000440598.1
ENST00000437743.1
ZNF138



zinc finger protein 138



chr11_-_83436446 0.698 ENST00000529399.1
DLG2
discs, large homolog 2 (Drosophila)
chr17_+_41994576 0.684 ENST00000588043.2
FAM215A
family with sequence similarity 215, member A (non-protein coding)
chr12_-_11091862 0.683 ENST00000537503.1
TAS2R14
taste receptor, type 2, member 14
chr2_-_239140276 0.677 ENST00000334973.4
AC016757.3
Protein LOC151174
chr2_+_241499719 0.674 ENST00000405954.1
DUSP28
dual specificity phosphatase 28
chr1_+_179263308 0.674 ENST00000426956.1
SOAT1
sterol O-acyltransferase 1
chr11_-_46408107 0.672 ENST00000433765.2
CHRM4
cholinergic receptor, muscarinic 4
chr11_+_61522844 0.669 ENST00000265460.5
MYRF
myelin regulatory factor
chr1_-_211307404 0.668 ENST00000367007.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr7_+_66093851 0.665 ENST00000275532.3
KCTD7
potassium channel tetramerization domain containing 7
chr10_-_50970382 0.633 ENST00000419399.1
ENST00000432695.1
OGDHL

oxoglutarate dehydrogenase-like

chr5_+_162930114 0.626 ENST00000280969.5
MAT2B
methionine adenosyltransferase II, beta
chr8_-_19615538 0.624 ENST00000517494.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr19_+_53073526 0.620 ENST00000596514.1
ENST00000391785.3
ENST00000301093.2
ZNF701


zinc finger protein 701


chr5_+_175490540 0.610 ENST00000515817.1
FAM153B
family with sequence similarity 153, member B
chr16_+_12070567 0.607 ENST00000566228.1
SNX29
sorting nexin 29
chrX_+_118602363 0.604 ENST00000317881.8
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr7_+_66093908 0.604 ENST00000443322.1
ENST00000449064.1
KCTD7

potassium channel tetramerization domain containing 7

chr22_-_50050986 0.603 ENST00000405854.1
C22orf34
chromosome 22 open reading frame 34
chr17_+_16593539 0.599 ENST00000340621.5
ENST00000399273.1
ENST00000443444.2
ENST00000360524.8
ENST00000456009.1
CCDC144A




coiled-coil domain containing 144A




chr10_-_98945264 0.596 ENST00000314867.5
SLIT1
slit homolog 1 (Drosophila)
chr10_-_50970322 0.582 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr9_+_131267052 0.574 ENST00000539582.1
GLE1
GLE1 RNA export mediator
chr7_+_64254766 0.574 ENST00000307355.7
ENST00000359735.3
ZNF138

zinc finger protein 138

chr3_+_190105909 0.568 ENST00000456423.1
CLDN16
claudin 16
chr3_+_9839335 0.568 ENST00000453882.1
ARPC4-TTLL3
ARPC4-TTLL3 readthrough
chr19_-_9546227 0.558 ENST00000361451.2
ENST00000361151.1
ZNF266

zinc finger protein 266

chr2_-_89310012 0.557 ENST00000493819.1
IGKV1-9
immunoglobulin kappa variable 1-9
chr7_-_102257139 0.549 ENST00000521076.1
ENST00000462172.1
ENST00000522801.1
ENST00000449970.2
ENST00000262940.7
RASA4




RAS p21 protein activator 4




chr14_+_45605157 0.543 ENST00000542564.2
FANCM
Fanconi anemia, complementation group M
chr12_-_122240792 0.539 ENST00000541657.1
ENST00000545885.1
ENST00000542933.1
ENST00000428029.2
ENST00000541694.1
ENST00000536662.1
ENST00000535643.1
RHOF
AC084018.1





ras homolog family member F (in filopodia)
AC084018.1





chr6_+_132455526 0.535 ENST00000443303.1
LINC01013
long intergenic non-protein coding RNA 1013
chr19_+_23945768 0.531 ENST00000486528.1
ENST00000496398.1
RPSAP58

ribosomal protein SA pseudogene 58

chr1_-_179457805 0.531 ENST00000600581.1
AL160286.1
Uncharacterized protein
chr6_-_8102279 0.529 ENST00000488226.2
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
chr5_-_22853429 0.523 ENST00000504376.2
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr1_+_10459111 0.520 ENST00000541529.1
ENST00000270776.8
ENST00000483936.1
ENST00000538557.1
PGD



phosphogluconate dehydrogenase



chr10_+_71075516 0.516 ENST00000436817.1
HK1
hexokinase 1
chr4_-_128887069 0.507 ENST00000541133.1
ENST00000296468.3
ENST00000513559.1
MFSD8


major facilitator superfamily domain containing 8


chr12_-_58240470 0.504 ENST00000548823.1
ENST00000398073.2
CTDSP2

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2

chr11_-_83435965 0.498 ENST00000434967.1
ENST00000530800.1
DLG2

discs, large homolog 2 (Drosophila)

chr8_-_19615435 0.496 ENST00000523262.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr7_-_91509986 0.496 ENST00000456229.1
ENST00000442961.1
ENST00000406735.2
ENST00000419292.1
ENST00000351870.3
MTERF




mitochondrial transcription termination factor




chr4_+_26862431 0.496 ENST00000465503.1
STIM2
stromal interaction molecule 2
chr6_-_107235287 0.495 ENST00000436659.1
ENST00000428750.1
ENST00000427903.1
RP1-60O19.1


RP1-60O19.1


chr19_-_9546177 0.492 ENST00000592292.1
ENST00000588221.1
ZNF266

zinc finger protein 266

chr19_-_57335682 0.491 ENST00000593931.1
ZIM2
zinc finger, imprinted 2
chr1_-_151431674 0.487 ENST00000531094.1
POGZ
pogo transposable element with ZNF domain
chr2_+_139259324 0.487 ENST00000280098.4
SPOPL
speckle-type POZ protein-like
chr21_-_16126181 0.484 ENST00000455253.2
AF127936.3
AF127936.3
chr7_-_102158157 0.481 ENST00000541662.1
ENST00000306682.6
ENST00000465829.1
RASA4B


RAS p21 protein activator 4B


chr4_+_128886532 0.477 ENST00000444616.1
ENST00000388795.5
C4orf29

chromosome 4 open reading frame 29

chr4_+_26862313 0.476 ENST00000467087.1
ENST00000382009.3
ENST00000237364.5
STIM2


stromal interaction molecule 2


chrX_+_150565038 0.476 ENST00000370361.1
VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr5_-_72861175 0.476 ENST00000504641.1
ANKRA2
ankyrin repeat, family A (RFXANK-like), 2
chr20_+_56964253 0.474 ENST00000395802.3
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr2_-_225434538 0.472 ENST00000409096.1
CUL3
cullin 3
chr5_-_156569754 0.471 ENST00000420343.1
MED7
mediator complex subunit 7
chr3_-_11888246 0.470 ENST00000455809.1
ENST00000444133.2
ENST00000273037.5
TAMM41


TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae)


chrX_+_57618269 0.467 ENST00000374888.1
ZXDB
zinc finger, X-linked, duplicated B
chr8_-_135652051 0.456 ENST00000522257.1
ZFAT
zinc finger and AT hook domain containing
chr18_-_2571210 0.456 ENST00000577166.1
METTL4
methyltransferase like 4
chr9_+_131266963 0.452 ENST00000309971.4
ENST00000372770.4
GLE1

GLE1 RNA export mediator

chr10_+_71075552 0.448 ENST00000298649.3
HK1
hexokinase 1
chr18_+_60190226 0.446 ENST00000269499.5
ZCCHC2
zinc finger, CCHC domain containing 2
chr11_+_28131821 0.442 ENST00000379199.2
ENST00000303459.6
METTL15

methyltransferase like 15

chr16_+_29817399 0.441 ENST00000545521.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr5_-_177210399 0.438 ENST00000510276.1
FAM153A
family with sequence similarity 153, member A
chr18_-_21166841 0.436 ENST00000269228.5
NPC1
Niemann-Pick disease, type C1
chr3_-_47555167 0.436 ENST00000296149.4
ELP6
elongator acetyltransferase complex subunit 6
chr19_+_4007644 0.430 ENST00000262971.2
PIAS4
protein inhibitor of activated STAT, 4
chr6_-_28226984 0.428 ENST00000423974.2
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr5_+_145583156 0.426 ENST00000265271.5
RBM27
RNA binding motif protein 27
chr11_+_46740730 0.423 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
F2


coagulation factor II (thrombin)


chr1_+_161719552 0.422 ENST00000367943.4
DUSP12
dual specificity phosphatase 12
chr1_+_179050512 0.418 ENST00000367627.3
TOR3A
torsin family 3, member A
chr3_-_197024965 0.418 ENST00000392382.2
DLG1
discs, large homolog 1 (Drosophila)
chr2_-_98280383 0.417 ENST00000289228.5
ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr14_-_36645674 0.413 ENST00000556013.2
PTCSC3
papillary thyroid carcinoma susceptibility candidate 3 (non-protein coding)
chr5_+_145583107 0.406 ENST00000506502.1
RBM27
RNA binding motif protein 27
chr20_-_7921090 0.404 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr6_+_132455118 0.398 ENST00000458028.1
LINC01013
long intergenic non-protein coding RNA 1013
chr15_+_43809797 0.396 ENST00000399453.1
ENST00000300231.5
MAP1A

microtubule-associated protein 1A

chr2_+_232826394 0.395 ENST00000409401.3
ENST00000441279.1
DIS3L2

DIS3 mitotic control homolog (S. cerevisiae)-like 2

chr7_+_92158083 0.387 ENST00000265732.5
ENST00000481551.1
ENST00000496410.1
RBM48


RNA binding motif protein 48


chr16_-_23607598 0.379 ENST00000562133.1
ENST00000570319.1
ENST00000007516.3
NDUFAB1


NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0043366 beta selection(GO:0043366)
0.7 2.0 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.6 4.0 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.5 2.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.5 1.5 GO:0071380 cellular response to prostaglandin E stimulus(GO:0071380)
0.4 1.7 GO:0032235 obsolete negative regulation of calcium ion transport via store-operated calcium channel activity(GO:0032235)
0.4 2.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.3 1.6 GO:0046108 uridine metabolic process(GO:0046108)
0.3 0.9 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.3 2.2 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.2 1.0 GO:0019532 oxalate transport(GO:0019532)
0.2 1.4 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.2 1.6 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.2 1.9 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.2 0.9 GO:0051958 methotrexate transport(GO:0051958)
0.2 0.6 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.2 0.7 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.2 0.5 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 0.6 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.2 1.4 GO:0071361 cellular response to ethanol(GO:0071361)
0.2 2.2 GO:0034587 piRNA metabolic process(GO:0034587)
0.2 2.2 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 0.3 GO:0035519 protein K29-linked ubiquitination(GO:0035519)
0.1 1.0 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 0.4 GO:0034310 primary alcohol catabolic process(GO:0034310)
0.1 0.4 GO:0071801 regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.1 0.6 GO:0015853 adenine transport(GO:0015853)
0.1 0.4 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.1 1.3 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1 0.5 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.1 0.5 GO:0019322 pentose biosynthetic process(GO:0019322)
0.1 0.4 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.1 1.4 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.1 0.4 GO:1903301 regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301)
0.1 1.3 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 0.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 1.3 GO:1903963 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.1 0.2 GO:0021769 orbitofrontal cortex development(GO:0021769) ventricular zone neuroblast division(GO:0021847) fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development(GO:0035607) fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915)
0.1 2.1 GO:0006691 leukotriene metabolic process(GO:0006691)
0.1 0.6 GO:0000959 mitochondrial RNA metabolic process(GO:0000959) transcription from mitochondrial promoter(GO:0006390)
0.1 0.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 1.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 3.2 GO:0007602 phototransduction(GO:0007602)
0.1 1.2 GO:0050832 defense response to fungus(GO:0050832)
0.1 1.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 0.8 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1 0.5 GO:0007064 mitotic sister chromatid cohesion(GO:0007064) kinetochore assembly(GO:0051382)
0.1 5.5 GO:0006968 cellular defense response(GO:0006968)
0.1 0.6 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.3 GO:0033522 histone H2A ubiquitination(GO:0033522)
0.0 0.4 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.3 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.5 GO:0050932 regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0 0.2 GO:0035444 nickel cation transport(GO:0015675) vanadium ion transport(GO:0015676) ferrous iron transport(GO:0015684) lead ion transport(GO:0015692) nickel cation transmembrane transport(GO:0035444) ferrous iron import(GO:0070627) iron ion import(GO:0097286)
0.0 0.5 GO:1901798 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 0.8 GO:0051205 protein insertion into membrane(GO:0051205)
0.0 1.5 GO:0051925 obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925)
0.0 0.1 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.0 1.0 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.0 0.7 GO:0007520 myoblast fusion(GO:0007520)
0.0 7.9 GO:0050900 leukocyte migration(GO:0050900)
0.0 0.5 GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein(GO:0042517)
0.0 1.1 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.8 GO:0051225 spindle assembly(GO:0051225)
0.0 0.2 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.2 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.0 0.1 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.3 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 1.4 GO:0061025 membrane fusion(GO:0061025)
0.0 0.1 GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.5 GO:0019048 modulation by virus of host morphology or physiology(GO:0019048)
0.0 0.4 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.6 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 10.3 GO:0006886 intracellular protein transport(GO:0006886)
0.0 1.2 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.0 0.3 GO:0031069 hair follicle morphogenesis(GO:0031069)
0.0 0.7 GO:0009056 catabolic process(GO:0009056)
0.0 0.1 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.7 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.0 1.0 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.9 GO:0019233 sensory perception of pain(GO:0019233)
0.0 0.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.1 GO:0032364 oxygen homeostasis(GO:0032364)
0.0 0.2 GO:0060334 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.1 GO:0032876 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.4 2.5 GO:0019815 immunoglobulin complex(GO:0019814) B cell receptor complex(GO:0019815)
0.2 1.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 1.2 GO:0045179 apical cortex(GO:0045179)
0.1 12.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 0.6 GO:0071817 MMXD complex(GO:0071817)
0.1 1.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 2.2 GO:0043186 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 0.3 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 0.5 GO:0005827 polar microtubule(GO:0005827)
0.1 0.7 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.1 0.8 GO:0070652 HAUS complex(GO:0070652)
0.0 12.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.4 GO:0005869 dynactin complex(GO:0005869)
0.0 0.9 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.2 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 1.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:0031592 centrosomal corona(GO:0031592)
0.0 2.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.1 GO:0000800 lateral element(GO:0000800)
0.0 0.6 GO:0001772 immunological synapse(GO:0001772)
0.0 1.7 GO:0030175 filopodium(GO:0030175)
0.0 0.3 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 1.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 4.9 GO:0005792 obsolete microsome(GO:0005792)
0.0 0.4 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.3 GO:0030426 growth cone(GO:0030426)
0.0 2.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.1 GO:0019717 obsolete synaptosome(GO:0019717)
0.0 1.8 GO:0060076 excitatory synapse(GO:0060076)
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 12.8 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.7 2.1 GO:0050051 leukotriene-B4 20-monooxygenase activity(GO:0050051)
0.7 2.6 GO:0004565 beta-galactosidase activity(GO:0004565)
0.5 2.4 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.5 1.4 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.3 1.6 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.3 2.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.3 0.9 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.3 1.9 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.2 0.7 GO:0003715 obsolete transcription termination factor activity(GO:0003715)
0.2 1.6 GO:0004875 complement receptor activity(GO:0004875)
0.2 0.9 GO:0015350 methotrexate transporter activity(GO:0015350)
0.2 2.0 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.2 1.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.2 1.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 1.6 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.2 1.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.2 0.8 GO:0031849 olfactory receptor binding(GO:0031849)
0.2 1.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 2.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.4 GO:0003973 (S)-2-hydroxy-acid oxidase activity(GO:0003973) oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1 0.4 GO:0031177 phosphopantetheine binding(GO:0031177)
0.1 0.4 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.1 1.0 GO:0004340 glucokinase activity(GO:0004340)
0.1 0.4 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.1 2.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 0.7 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.5 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.1 1.4 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.1 0.6 GO:0005345 purine nucleobase transmembrane transporter activity(GO:0005345)
0.1 0.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 2.2 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 0.6 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.1 GO:0050780 dopamine receptor binding(GO:0050780)
0.1 0.5 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.1 1.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 4.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 0.5 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 1.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 1.2 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.7 GO:0008527 taste receptor activity(GO:0008527)
0.0 1.9 GO:0019843 rRNA binding(GO:0019843)
0.0 0.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.2 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.0 1.4 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.2 GO:0070835 cobalt ion transmembrane transporter activity(GO:0015087) ferrous iron transmembrane transporter activity(GO:0015093) lead ion transmembrane transporter activity(GO:0015094) nickel cation transmembrane transporter activity(GO:0015099) vanadium ion transmembrane transporter activity(GO:0015100) chromium ion transmembrane transporter activity(GO:0070835)
0.0 0.4 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.7 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.1 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 1.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.3 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.8 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0 6.0 GO:0004518 nuclease activity(GO:0004518)
0.0 0.2 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.1 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.5 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.5 GO:0030332 cyclin binding(GO:0030332)
0.0 2.8 GO:0005254 chloride channel activity(GO:0005254)
0.0 1.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.3 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 4.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.0 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670)
0.0 0.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.3 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 1.8 GO:0005179 hormone activity(GO:0005179)
0.0 0.5 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.5 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.1 0.3 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 4.8 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 2.5 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.2 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.1 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway