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Illumina Body Map 2: averaged replicates

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Results for PRRX1_ALX4_PHOX2A

Z-value: 1.39

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Transcription factors associated with PRRX1_ALX4_PHOX2A

Gene Symbol Gene ID Gene Info
PRRX1
ENSG00000116132.7 paired related homeobox 1
ALX4
ENSG00000052850.5 ALX homeobox 4
PHOX2A
ENSG00000165462.5 paired like homeobox 2A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PHOX2Ahg19_v2_chr11_-_71955210_71955227-0.567.7e-04Click!
PRRX1hg19_v2_chr1_+_170632250_1706322770.212.5e-01Click!
ALX4hg19_v2_chr11_-_44331679_44331716-0.105.9e-01Click!

Activity profile of PRRX1_ALX4_PHOX2A motif

Sorted Z-values of PRRX1_ALX4_PHOX2A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_69865866 5.23 ENST00000354393.2
MYPN
myopalladin
chr5_+_36606700 5.07 ENST00000416645.2
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_-_195310802 4.68 ENST00000421243.1
ENST00000453131.1
APOD
apolipoprotein D
chr6_+_53964336 4.59 ENST00000447836.2
ENST00000511678.1
MLIP
muscular LMNA-interacting protein
chr10_+_24544249 4.55 ENST00000430453.2
KIAA1217
KIAA1217
chr1_+_170632250 3.72 ENST00000367760.3
PRRX1
paired related homeobox 1
chr6_-_76072719 3.44 ENST00000370020.1
FILIP1
filamin A interacting protein 1
chr15_+_51669444 2.97 ENST00000396399.2
GLDN
gliomedin
chr8_-_86253888 2.95 ENST00000522389.1
ENST00000432364.2
ENST00000517618.1
CA1
carbonic anhydrase I
chr7_+_80255472 2.85 ENST00000428497.1
CD36
CD36 molecule (thrombospondin receptor)
chrX_-_15332665 2.75 ENST00000537676.1
ENST00000344384.4
ASB11
ankyrin repeat and SOCS box containing 11
chr1_-_94147385 2.66 ENST00000260502.6
BCAR3
breast cancer anti-estrogen resistance 3
chr8_-_26724784 2.46 ENST00000380573.3
ADRA1A
adrenoceptor alpha 1A
chr1_-_92371839 2.21 ENST00000370399.2
TGFBR3
transforming growth factor, beta receptor III
chr15_+_51669513 2.17 ENST00000558426.1
GLDN
gliomedin
chr11_-_40315640 2.16 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr9_+_124329336 2.10 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr2_-_175629164 2.05 ENST00000409323.1
ENST00000261007.5
ENST00000348749.5
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr1_-_232651312 2.02 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr2_+_179184955 1.99 ENST00000315022.2
OSBPL6
oxysterol binding protein-like 6
chr5_+_140743859 1.93 ENST00000518069.1
PCDHGA5
protocadherin gamma subfamily A, 5
chr9_-_95298254 1.92 ENST00000444490.2
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr7_-_111032971 1.83 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr18_-_52989217 1.81 ENST00000570287.2
TCF4
transcription factor 4
chr18_-_52989525 1.76 ENST00000457482.3
TCF4
transcription factor 4
chr2_+_102413726 1.74 ENST00000350878.4
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr2_-_175629135 1.67 ENST00000409542.1
ENST00000409219.1
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr2_+_29001711 1.62 ENST00000418910.1
PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme
chr18_-_21891460 1.61 ENST00000357041.4
OSBPL1A
oxysterol binding protein-like 1A
chr1_+_50459990 1.61 ENST00000448346.1
AL645730.2
AL645730.2
chr4_+_160188306 1.54 ENST00000510510.1
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr9_-_95298927 1.51 ENST00000395534.2
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr17_-_9694614 1.49 ENST00000330255.5
ENST00000571134.1
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr6_+_53883708 1.48 ENST00000514921.1
ENST00000274897.5
ENST00000370877.2
MLIP
muscular LMNA-interacting protein
chr20_+_31823792 1.46 ENST00000375413.4
ENST00000354297.4
ENST00000375422.2
BPIFA1
BPI fold containing family A, member 1
chr4_+_160188889 1.44 ENST00000264431.4
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr12_-_16761117 1.43 ENST00000538051.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr14_-_95236551 1.42 ENST00000238558.3
GSC
goosecoid homeobox
chr12_-_21928515 1.38 ENST00000537950.1
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr16_-_21875424 1.38 ENST00000541674.1
NPIPB4
nuclear pore complex interacting protein family, member B4
chr9_-_71869642 1.37 ENST00000600472.1
AL358113.1
Tight junction protein 2 (Zona occludens 2) isoform 1 variant; Uncharacterized protein
chr4_-_176812842 1.36 ENST00000507540.1
GPM6A
glycoprotein M6A
chr12_-_118796971 1.36 ENST00000542902.1
TAOK3
TAO kinase 3
chr2_-_69180083 1.31 ENST00000328895.4
GKN2
gastrokine 2
chr8_-_10512569 1.31 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr8_+_67039131 1.30 ENST00000315962.4
ENST00000353317.5
TRIM55
tripartite motif containing 55
chr1_+_186265399 1.29 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4
proteoglycan 4
chr1_-_234667504 1.27 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr3_-_196242233 1.27 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr18_+_20714525 1.23 ENST00000400473.2
CABLES1
Cdk5 and Abl enzyme substrate 1
chr10_+_89420706 1.22 ENST00000427144.2
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr14_+_95078714 1.22 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr6_+_53883790 1.21 ENST00000509997.1
MLIP
muscular LMNA-interacting protein
chr6_-_138833630 1.20 ENST00000533765.1
NHSL1
NHS-like 1
chr10_-_75226166 1.19 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr3_+_69985734 1.19 ENST00000314557.6
ENST00000394351.3
MITF
microphthalmia-associated transcription factor
chr12_-_11463353 1.18 ENST00000279575.1
ENST00000535904.1
ENST00000445719.2
PRB4
proline-rich protein BstNI subfamily 4
chr4_-_100356551 1.17 ENST00000209665.4
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr7_+_107224364 1.16 ENST00000491150.1
BCAP29
B-cell receptor-associated protein 29
chr5_+_142149932 1.15 ENST00000274498.4
ARHGAP26
Rho GTPase activating protein 26
chr10_-_102989551 1.14 ENST00000370193.2
LBX1
ladybird homeobox 1
chr12_-_91573249 1.12 ENST00000550099.1
ENST00000546391.1
ENST00000551354.1
DCN
decorin
chr3_-_157824292 1.10 ENST00000483851.2
SHOX2
short stature homeobox 2
chr10_-_29923893 1.08 ENST00000355867.4
SVIL
supervillin
chr3_+_69985792 1.04 ENST00000531774.1
MITF
microphthalmia-associated transcription factor
chr1_+_109756523 1.04 ENST00000234677.2
ENST00000369923.4
SARS
seryl-tRNA synthetase
chr12_-_16761007 1.02 ENST00000354662.1
ENST00000441439.2
LMO3
LIM domain only 3 (rhombotin-like 2)
chr10_+_53806501 1.01 ENST00000373975.2
PRKG1
protein kinase, cGMP-dependent, type I
chr17_+_53342311 1.00 ENST00000226067.5
HLF
hepatic leukemia factor
chr12_+_12878829 1.00 ENST00000326765.6
APOLD1
apolipoprotein L domain containing 1
chr6_-_134639235 1.00 ENST00000533224.1
SGK1
serum/glucocorticoid regulated kinase 1
chr12_-_91546926 1.00 ENST00000550758.1
DCN
decorin
chr5_-_115872142 0.97 ENST00000510263.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr4_-_100356291 0.96 ENST00000476959.1
ENST00000482593.1
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr1_-_178838404 0.96 ENST00000444255.1
ANGPTL1
angiopoietin-like 1
chr2_-_69180012 0.95 ENST00000481498.1
GKN2
gastrokine 2
chr8_-_57472154 0.92 ENST00000499425.1
ENST00000523664.1
ENST00000518943.1
ENST00000524338.1
LINC00968
long intergenic non-protein coding RNA 968
chr2_+_54683419 0.91 ENST00000356805.4
SPTBN1
spectrin, beta, non-erythrocytic 1
chr21_-_35899113 0.90 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
RCAN1
regulator of calcineurin 1
chr7_-_27169801 0.89 ENST00000511914.1
HOXA4
homeobox A4
chr8_-_16035454 0.89 ENST00000355282.2
MSR1
macrophage scavenger receptor 1
chr19_-_11456905 0.86 ENST00000588560.1
ENST00000592952.1
TMEM205
transmembrane protein 205
chr4_-_89951028 0.86 ENST00000506913.1
FAM13A
family with sequence similarity 13, member A
chr1_+_183774285 0.84 ENST00000539189.1
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr9_-_95244781 0.82 ENST00000375544.3
ENST00000375543.1
ENST00000395538.3
ENST00000450139.2
ASPN
asporin
chr1_-_165414414 0.82 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr15_+_44092784 0.82 ENST00000458412.1
HYPK
huntingtin interacting protein K
chr7_-_93520259 0.82 ENST00000222543.5
TFPI2
tissue factor pathway inhibitor 2
chr1_+_154401791 0.81 ENST00000476006.1
IL6R
interleukin 6 receptor
chr1_+_62439037 0.81 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr1_+_12976450 0.81 ENST00000361079.2
PRAMEF7
PRAME family member 7
chr8_-_62602327 0.80 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr5_-_136649218 0.80 ENST00000510405.1
SPOCK1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chrX_+_39868501 0.80 ENST00000447651.1
AC092198.1
AC092198.1
chr17_-_5321549 0.80 ENST00000572809.1
NUP88
nucleoporin 88kDa
chr12_-_75784669 0.79 ENST00000552497.1
ENST00000551829.1
ENST00000436898.1
ENST00000442339.2
CAPS2
calcyphosine 2
chr4_+_76649753 0.78 ENST00000603759.1
USO1
USO1 vesicle transport factor
chr6_+_55192267 0.78 ENST00000340465.2
GFRAL
GDNF family receptor alpha like
chr7_+_90338547 0.78 ENST00000446790.1
CDK14
cyclin-dependent kinase 14
chr9_-_95298314 0.77 ENST00000344604.5
ENST00000375540.1
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr1_-_242162375 0.74 ENST00000357246.3
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr19_-_11456872 0.73 ENST00000586218.1
TMEM205
transmembrane protein 205
chr5_+_137203557 0.73 ENST00000515645.1
MYOT
myotilin
chr5_-_115872124 0.73 ENST00000515009.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr6_-_137314371 0.71 ENST00000432330.1
ENST00000418699.1
RP11-55K22.5
RP11-55K22.5
chr2_-_55496174 0.71 ENST00000417363.1
ENST00000412530.1
ENST00000394600.3
ENST00000366137.2
ENST00000420637.1
MTIF2
mitochondrial translational initiation factor 2
chr14_-_38064198 0.71 ENST00000250448.2
FOXA1
forkhead box A1
chr10_+_24755416 0.71 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr16_+_7382745 0.70 ENST00000436368.2
ENST00000311745.5
ENST00000355637.4
ENST00000340209.4
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr13_+_102142296 0.69 ENST00000376162.3
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr5_+_142149955 0.69 ENST00000378004.3
ARHGAP26
Rho GTPase activating protein 26
chr2_+_223725723 0.68 ENST00000535678.1
ACSL3
acyl-CoA synthetase long-chain family member 3
chr1_+_183774240 0.68 ENST00000360851.3
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr21_+_17442799 0.68 ENST00000602580.1
ENST00000458468.1
ENST00000602935.1
LINC00478
long intergenic non-protein coding RNA 478
chr10_-_90967063 0.68 ENST00000371852.2
CH25H
cholesterol 25-hydroxylase
chr9_+_87286997 0.68 ENST00000395866.2
NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr12_-_118796910 0.67 ENST00000541186.1
ENST00000539872.1
TAOK3
TAO kinase 3
chr7_-_93520191 0.67 ENST00000545378.1
TFPI2
tissue factor pathway inhibitor 2
chr2_+_101437487 0.67 ENST00000427413.1
ENST00000542504.1
NPAS2
neuronal PAS domain protein 2
chr14_+_101293687 0.66 ENST00000455286.1
MEG3
maternally expressed 3 (non-protein coding)
chr3_-_194188956 0.66 ENST00000256031.4
ENST00000446356.1
ATP13A3
ATPase type 13A3
chr21_+_43619796 0.66 ENST00000398457.2
ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr1_+_243419306 0.66 ENST00000355875.4
ENST00000391846.1
ENST00000366541.3
ENST00000343783.6
SDCCAG8
serologically defined colon cancer antigen 8
chr10_-_10836865 0.66 ENST00000446372.2
SFTA1P
surfactant associated 1, pseudogene
chr10_-_50396407 0.64 ENST00000374153.2
ENST00000374151.3
C10orf128
chromosome 10 open reading frame 128
chr6_+_121756809 0.63 ENST00000282561.3
GJA1
gap junction protein, alpha 1, 43kDa
chr6_+_3259148 0.63 ENST00000419065.2
ENST00000473000.2
ENST00000451246.2
ENST00000454610.2
PSMG4
proteasome (prosome, macropain) assembly chaperone 4
chr19_-_11456935 0.63 ENST00000590788.1
ENST00000586590.1
ENST00000589555.1
ENST00000586956.1
ENST00000593256.2
ENST00000447337.1
ENST00000591677.1
ENST00000586701.1
ENST00000589655.1
TMEM205
RAB3D
transmembrane protein 205
RAB3D, member RAS oncogene family
chr12_-_47219733 0.63 ENST00000547477.1
ENST00000447411.1
ENST00000266579.4
SLC38A4
solute carrier family 38, member 4
chr4_-_76957214 0.63 ENST00000306621.3
CXCL11
chemokine (C-X-C motif) ligand 11
chr1_+_198985262 0.62 ENST00000432488.1
RP11-16L9.4
RP11-16L9.4
chr10_-_50396425 0.62 ENST00000374148.1
C10orf128
chromosome 10 open reading frame 128
chr1_+_145525015 0.61 ENST00000539363.1
ENST00000538811.1
ITGA10
integrin, alpha 10
chr8_-_93107443 0.61 ENST00000360348.2
ENST00000520428.1
ENST00000518992.1
ENST00000520556.1
ENST00000518317.1
ENST00000521319.1
ENST00000521375.1
ENST00000518449.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_-_134639180 0.61 ENST00000367858.5
SGK1
serum/glucocorticoid regulated kinase 1
chr5_-_142780280 0.61 ENST00000424646.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr16_+_24549014 0.60 ENST00000564314.1
ENST00000567686.1
RBBP6
retinoblastoma binding protein 6
chr5_+_140762268 0.59 ENST00000518325.1
PCDHGA7
protocadherin gamma subfamily A, 7
chr3_-_12587055 0.59 ENST00000564146.3
C3orf83
chromosome 3 open reading frame 83
chr16_+_6533729 0.59 ENST00000551752.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr11_+_12766583 0.58 ENST00000361985.2
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr6_-_107235378 0.58 ENST00000606430.1
RP1-60O19.1
RP1-60O19.1
chr11_-_58035732 0.57 ENST00000395079.2
OR10W1
olfactory receptor, family 10, subfamily W, member 1
chr19_+_50016610 0.57 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr4_-_176733897 0.57 ENST00000393658.2
GPM6A
glycoprotein M6A
chr8_+_86851932 0.57 ENST00000517368.1
CTA-392E5.1
CTA-392E5.1
chr4_-_83769996 0.57 ENST00000511338.1
SEC31A
SEC31 homolog A (S. cerevisiae)
chr3_+_186692745 0.57 ENST00000438590.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr5_+_137203465 0.56 ENST00000239926.4
MYOT
myotilin
chr2_+_119699742 0.55 ENST00000327097.4
MARCO
macrophage receptor with collagenous structure
chr6_+_3259122 0.55 ENST00000438998.2
ENST00000380305.4
PSMG4
proteasome (prosome, macropain) assembly chaperone 4
chr13_+_20268547 0.55 ENST00000601204.1
AL354808.2
AL354808.2
chr1_-_21377383 0.54 ENST00000374935.3
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr9_+_27524283 0.54 ENST00000276943.2
IFNK
interferon, kappa
chrX_+_11311533 0.54 ENST00000380714.3
ENST00000380712.3
ENST00000348912.4
AMELX
amelogenin, X-linked
chr19_-_11456722 0.54 ENST00000354882.5
TMEM205
transmembrane protein 205
chr2_+_119699864 0.54 ENST00000541757.1
ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chr6_-_56492816 0.54 ENST00000522360.1
DST
dystonin
chr3_+_12329397 0.54 ENST00000397015.2
PPARG
peroxisome proliferator-activated receptor gamma
chr4_+_169575875 0.53 ENST00000503457.1
PALLD
palladin, cytoskeletal associated protein
chr12_-_91573316 0.53 ENST00000393155.1
DCN
decorin
chr2_-_145275828 0.53 ENST00000392861.2
ENST00000409211.1
ZEB2
zinc finger E-box binding homeobox 2
chr16_+_6533380 0.53 ENST00000552089.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr1_-_157069590 0.53 ENST00000454449.2
ETV3L
ets variant 3-like
chr3_-_149293990 0.52 ENST00000472417.1
WWTR1
WW domain containing transcription regulator 1
chr12_-_9360966 0.52 ENST00000261336.2
PZP
pregnancy-zone protein
chr3_-_167191814 0.52 ENST00000466903.1
ENST00000264677.4
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr12_-_7656357 0.52 ENST00000396620.3
ENST00000432237.2
ENST00000359156.4
CD163
CD163 molecule
chr2_+_223725652 0.52 ENST00000357430.3
ENST00000392066.3
ACSL3
acyl-CoA synthetase long-chain family member 3
chr3_+_153839149 0.51 ENST00000465093.1
ENST00000465817.1
ARHGEF26
Rho guanine nucleotide exchange factor (GEF) 26
chr12_-_91573132 0.51 ENST00000550563.1
ENST00000546370.1
DCN
decorin
chr10_-_50396357 0.51 ENST00000453436.1
ENST00000474718.1
C10orf128
chromosome 10 open reading frame 128
chr5_-_16738451 0.51 ENST00000274203.9
ENST00000515803.1
MYO10
myosin X
chr10_+_13141441 0.50 ENST00000263036.5
OPTN
optineurin
chr5_+_98109322 0.50 ENST00000513185.1
RGMB
repulsive guidance molecule family member b
chr1_-_178840157 0.50 ENST00000367629.1
ENST00000234816.2
ANGPTL1
angiopoietin-like 1
chr8_-_6420930 0.50 ENST00000325203.5
ANGPT2
angiopoietin 2
chr3_-_124774802 0.49 ENST00000311127.4
HEG1
heart development protein with EGF-like domains 1
chr5_-_134735568 0.49 ENST00000510038.1
ENST00000304332.4
H2AFY
H2A histone family, member Y
chr2_+_75873902 0.49 ENST00000393909.2
ENST00000358788.6
ENST00000409374.1
MRPL19
mitochondrial ribosomal protein L19
chr12_-_10959892 0.49 ENST00000240615.2
TAS2R8
taste receptor, type 2, member 8
chr12_-_118797475 0.48 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr11_+_1295809 0.48 ENST00000598274.1
AC136297.1
Uncharacterized protein
chr4_+_76649797 0.48 ENST00000538159.1
ENST00000514213.2
USO1
USO1 vesicle transport factor
chr4_-_76649546 0.48 ENST00000508510.1
ENST00000509561.1
ENST00000499709.2
ENST00000511868.1
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr12_+_49621658 0.47 ENST00000541364.1
TUBA1C
tubulin, alpha 1c
chr1_+_87012753 0.47 ENST00000370563.3
CLCA4
chloride channel accessory 4
chr16_+_22518495 0.47 ENST00000541154.1
NPIPB5
nuclear pore complex interacting protein family, member B5
chr7_+_55980331 0.46 ENST00000429591.2
ZNF713
zinc finger protein 713
chr4_-_68829144 0.46 ENST00000508048.1
TMPRSS11A
transmembrane protease, serine 11A
chr11_-_58499434 0.46 ENST00000344743.3
ENST00000278400.3
GLYAT
glycine-N-acyltransferase
chr7_+_123241908 0.46 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
ASB15
ankyrin repeat and SOCS box containing 15
chr17_+_75181292 0.46 ENST00000431431.2
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr10_+_13141585 0.46 ENST00000378764.2
OPTN
optineurin
chrX_+_119737806 0.45 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr4_-_186578674 0.45 ENST00000438278.1
SORBS2
sorbin and SH3 domain containing 2
chr4_+_155484103 0.45 ENST00000302068.4
FGB
fibrinogen beta chain
chr9_+_88556444 0.45 ENST00000376040.1
NAA35
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
chr12_-_8088871 0.44 ENST00000075120.7
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr20_+_36974759 0.44 ENST00000217407.2
LBP
lipopolysaccharide binding protein

Network of associatons between targets according to the STRING database.

First level regulatory network of PRRX1_ALX4_PHOX2A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.7 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.8 2.5 GO:0003099 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.6 1.8 GO:0061300 cerebellum vasculature development(GO:0061300)
0.5 2.1 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.5 1.4 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.5 5.1 GO:0070779 gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.4 2.2 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.4 3.0 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.4 2.1 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.4 3.7 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.4 4.9 GO:0048664 neuron fate determination(GO:0048664)
0.4 1.2 GO:2001247 positive regulation of phosphatidylcholine biosynthetic process(GO:2001247)
0.4 1.5 GO:0042710 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
0.3 1.0 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.3 1.2 GO:0000103 sulfate assimilation(GO:0000103)
0.3 0.3 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.3 5.4 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.3 3.2 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2 2.8 GO:2000334 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.2 0.7 GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.2 0.8 GO:0002384 hepatic immune response(GO:0002384)
0.2 5.2 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.2 0.8 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.2 0.6 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.2 2.4 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.2 0.8 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.2 0.7 GO:0055099 detection of endogenous stimulus(GO:0009726) response to high density lipoprotein particle(GO:0055099)
0.2 0.5 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.2 0.5 GO:1904815 negative regulation of protein localization to chromosome, telomeric region(GO:1904815)
0.2 0.6 GO:0010645 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.2 0.3 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.2 0.9 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.2 0.5 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.4 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.1 0.7 GO:0015862 uridine transport(GO:0015862)
0.1 0.7 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.1 1.7 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.5 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1 0.4 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.1 0.3 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1 0.6 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 0.5 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.1 0.7 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.1 1.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 1.4 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 1.4 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.1 1.3 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.1 1.7 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 0.5 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
0.1 1.2 GO:0097475 motor neuron migration(GO:0097475)
0.1 1.3 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 3.1 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 0.4 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.1 0.4 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.1 1.6 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.1 0.3 GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365)
0.1 0.4 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.1 0.6 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 1.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 0.8 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.5 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.1 0.6 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 0.4 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.3 GO:0060166 olfactory pit development(GO:0060166)
0.1 0.2 GO:2001186 negative regulation of CD8-positive, alpha-beta T cell activation(GO:2001186)
0.1 0.7 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 1.0 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.1 0.3 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.1 2.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 1.2 GO:0043248 proteasome assembly(GO:0043248)
0.1 1.4 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 0.8 GO:0021759 globus pallidus development(GO:0021759)
0.1 3.8 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.1 0.4 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 0.8 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.2 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.1 0.2 GO:1902269 positive regulation of polyamine transmembrane transport(GO:1902269)
0.1 0.3 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.1 0.5 GO:0035494 SNARE complex disassembly(GO:0035494)
0.1 0.4 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 1.7 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.5 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.1 3.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 0.5 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 1.0 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.2 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.0 0.1 GO:1903414 spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988)
0.0 0.4 GO:0009597 detection of virus(GO:0009597)
0.0 0.4 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.0 0.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.2 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.0 0.3 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.0 0.6 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.2 GO:0021816 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.0 0.3 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.1 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.0 2.2 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 1.5 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.0 0.6 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 1.8 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.5 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.7 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.0 0.7 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.5 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.5 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.7 GO:0051775 response to redox state(GO:0051775)
0.0 0.2 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.0 0.5 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.1 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.0 0.5 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.1 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.5 GO:0072307 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0 0.5 GO:0006544 glycine metabolic process(GO:0006544)
0.0 0.0 GO:1904106 protein localization to microvillus(GO:1904106)
0.0 0.3 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0 0.3 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 1.1 GO:0043277 apoptotic cell clearance(GO:0043277)
0.0 1.5 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.0 0.4 GO:0072718 response to cisplatin(GO:0072718)
0.0 1.3 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.5 GO:0021554 optic nerve development(GO:0021554)
0.0 1.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.8 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.1 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.0 1.9 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.3 GO:0015825 L-serine transport(GO:0015825)
0.0 1.8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.3 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.4 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 1.7 GO:0006953 acute-phase response(GO:0006953)
0.0 4.5 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.5 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.6 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.9 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.2 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.0 0.4 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.1 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.0 0.2 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.4 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 1.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 4.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 5.2 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.3 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.2 GO:0003383 apical constriction(GO:0003383)
0.0 0.2 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.3 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.0 0.9 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.1 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.6 GO:0043066 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069)
0.0 0.1 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
0.0 0.4 GO:0009812 flavonoid metabolic process(GO:0009812)
0.0 2.8 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.5 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.1 GO:0071468 cellular response to acidic pH(GO:0071468)
0.0 0.1 GO:0070836 caveola assembly(GO:0070836)
0.0 0.1 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795) negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.6 GO:1901099 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.3 GO:0007184 SMAD protein import into nucleus(GO:0007184)
0.0 0.0 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.0 0.5 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.2 GO:0046069 cGMP catabolic process(GO:0046069)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:1990032 parallel fiber(GO:1990032)
0.6 1.8 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.4 2.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.2 3.2 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2 1.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.2 0.8 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 4.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 3.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.4 GO:0070993 translation preinitiation complex(GO:0070993)
0.1 0.6 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.1 1.2 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.6 GO:0042587 glycogen granule(GO:0042587)
0.1 0.6 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.6 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 0.3 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 0.4 GO:0031417 NatC complex(GO:0031417)
0.1 0.5 GO:0031673 H zone(GO:0031673)
0.1 0.9 GO:0032437 cuticular plate(GO:0032437)
0.1 0.8 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.6 GO:0005916 fascia adherens(GO:0005916)
0.1 1.0 GO:0005577 fibrinogen complex(GO:0005577)
0.1 2.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.1 GO:0036449 microtubule minus-end(GO:0036449)
0.1 2.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.5 GO:0001740 Barr body(GO:0001740)
0.1 0.3 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 0.3 GO:0031905 early endosome lumen(GO:0031905)
0.1 7.5 GO:0005581 collagen trimer(GO:0005581)
0.1 0.1 GO:0060171 stereocilium membrane(GO:0060171)
0.1 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.3 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.3 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.2 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.4 GO:1990812 growth cone filopodium(GO:1990812)
0.0 0.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 7.7 GO:0016605 PML body(GO:0016605)
0.0 0.7 GO:0098794 postsynapse(GO:0098794)
0.0 0.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 10.0 GO:0030018 Z disc(GO:0030018)
0.0 1.4 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.7 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0071438 invadopodium membrane(GO:0071438)
0.0 2.7 GO:0045178 basal part of cell(GO:0045178)
0.0 0.5 GO:0032433 filopodium tip(GO:0032433)
0.0 0.6 GO:0042588 zymogen granule(GO:0042588)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 1.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 5.3 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 0.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.4 GO:0097433 dense body(GO:0097433)
0.0 0.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.9 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.4 GO:0033268 node of Ranvier(GO:0033268)
0.0 1.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.7 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0043194 axon initial segment(GO:0043194)
0.0 0.1 GO:0032280 symmetric synapse(GO:0032280)
0.0 3.7 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.3 GO:0098576 lumenal side of membrane(GO:0098576)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 2.1 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.2 GO:0070052 collagen V binding(GO:0070052)
0.8 2.5 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.7 2.2 GO:0070123 transforming growth factor beta receptor activity, type III(GO:0070123)
0.5 2.1 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.5 5.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 1.2 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.4 3.0 GO:0004064 arylesterase activity(GO:0004064)
0.3 1.0 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.3 1.4 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.3 1.6 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.3 2.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.3 0.8 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.3 0.8 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.3 2.8 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.2 2.9 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.2 0.7 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.2 0.8 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 1.0 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 5.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.2 0.5 GO:0046848 hydroxyapatite binding(GO:0046848)
0.2 3.6 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 1.7 GO:0004111 creatine kinase activity(GO:0004111)
0.2 1.5 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 5.8 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 3.7 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.9 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.6 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.6 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.7 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.1 0.4 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 0.5 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
0.1 1.2 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 0.3 GO:1902271 D3 vitamins binding(GO:1902271)
0.1 0.4 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.1 4.7 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.5 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.1 0.5 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.6 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.5 GO:0039552 RIG-I binding(GO:0039552)
0.1 0.3 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.1 3.6 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.6 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.1 2.4 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.6 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 0.3 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1 0.2 GO:0052591 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.1 2.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.3 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 0.5 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.1 0.6 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.4 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 1.7 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 1.5 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 1.1 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 2.6 GO:0070888 E-box binding(GO:0070888)
0.0 0.4 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.1 GO:0097689 iron channel activity(GO:0097689)
0.0 0.3 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.0 0.5 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 1.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 1.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 1.3 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.9 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.9 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.5 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 0.2 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.8 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.7 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.2 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 1.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.7 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 5.8 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 5.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.1 GO:0000035 acyl binding(GO:0000035)
0.0 0.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.9 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.2 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.9 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.4 GO:0036122 BMP binding(GO:0036122)
0.0 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.2 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.8 GO:0031489 myosin V binding(GO:0031489)
0.0 0.3 GO:0001758 retinal dehydrogenase activity(GO:0001758) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.6 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.3 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.7 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.3 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.7 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.5 GO:0000339 RNA cap binding(GO:0000339)
0.0 2.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.3 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.1 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.7 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.3 GO:0070402 NADPH binding(GO:0070402)
0.0 0.6 GO:0005549 odorant binding(GO:0005549)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.3 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.0 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 0.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.1 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.6 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.6 GO:0005044 scavenger receptor activity(GO:0005044)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 0.8 ST STAT3 PATHWAY STAT3 Pathway
0.0 2.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.8 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 2.7 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 4.3 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 1.3 PID ARF 3PATHWAY Arf1 pathway
0.0 3.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 2.1 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.1 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.8 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.7 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.7 PID INSULIN PATHWAY Insulin Pathway
0.0 1.0 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 4.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.8 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.0 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 1.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 2.7 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.6 PID PLK1 PATHWAY PLK1 signaling events
0.0 7.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 1.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.6 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.2 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.6 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 3.0 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 2.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 3.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 5.7 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.6 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 2.6 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 3.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.8 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 1.9 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.4 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.6 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.6 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 2.8 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 1.0 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.7 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.0 REACTOME BILE ACID AND BILE SALT METABOLISM Genes involved in Bile acid and bile salt metabolism
0.0 1.6 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.6 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.3 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.4 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.8 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 2.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.0 0.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 1.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.2 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.6 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.8 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.5 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.3 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 2.1 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.7 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.5 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression
0.0 0.3 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 3.2 REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation