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Illumina Body Map 2: averaged replicates
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Results for RAD21_SMC3
Z-value: 1.75
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Transcription factors associated with RAD21_SMC3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RAD21 | hg19_v2_chr8_-_117886563_117886605 | -0.17 | 3.5e-01 | Click! |
| SMC3 | hg19_v2_chr10_+_112327425_112327516 | 0.09 | 6.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_22697537 Show fit | 3.55 |
ENST00000427632.2
|
immunoglobulin lambda variable 9-49 |
|
| chr22_+_22735135 Show fit | 3.53 |
ENST00000390297.2
|
immunoglobulin lambda variable 1-44 |
|
| chr22_+_22786288 Show fit | 3.38 |
ENST00000390301.2
|
immunoglobulin lambda variable 1-36 |
|
| chr8_-_27850180 Show fit | 3.31 |
ENST00000380385.2
ENST00000301906.4 ENST00000354914.3 |
scavenger receptor class A, member 5 (putative) |
|
| chr22_+_22764088 Show fit | 3.24 |
ENST00000390299.2
|
immunoglobulin lambda variable 1-40 |
|
| chr22_+_23040274 Show fit | 3.04 |
ENST00000390306.2
|
immunoglobulin lambda variable 2-23 |
|
| chr22_+_22723969 Show fit | 2.97 |
ENST00000390295.2
|
immunoglobulin lambda variable 7-46 (gene/pseudogene) |
|
| chr2_+_114737472 Show fit | 2.95 |
ENST00000420161.1
|
AC110769.3 |
|
| chr14_+_94405901 Show fit | 2.88 |
ENST00000557646.1
|
Uncharacterized protein |
|
| chr8_-_27850141 Show fit | 2.72 |
ENST00000524352.1
|
scavenger receptor class A, member 5 (putative) |
Network of associatons between targets according to the STRING database.
First level regulatory network of RAD21_SMC3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.2 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.1 | 13.0 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.2 | 6.1 | GO:0034755 | iron ion transmembrane transport(GO:0034755) |
| 0.0 | 5.6 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 5.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.2 | 4.3 | GO:2000291 | regulation of myoblast proliferation(GO:2000291) |
| 1.3 | 3.9 | GO:0072573 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) |
| 0.1 | 3.9 | GO:0097435 | fibril organization(GO:0097435) |
| 0.4 | 3.8 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.0 | 3.6 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 11.3 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 7.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 6.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 5.8 | GO:0000785 | chromatin(GO:0000785) |
| 0.0 | 5.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 5.3 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.2 | 3.8 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 3.1 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.1 | 3.0 | GO:0032059 | bleb(GO:0032059) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.9 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 9.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 7.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 6.7 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.1 | 6.0 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 5.2 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 5.0 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 4.2 | GO:0019838 | growth factor binding(GO:0019838) |
| 0.1 | 4.0 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.2 | 3.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.4 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 6.2 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 4.1 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.1 | 4.1 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 3.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 2.8 | SIG CHEMOTAXIS | Genes related to chemotaxis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 9.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 4.6 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 4.6 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 4.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 3.9 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 3.8 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.2 | 2.9 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.1 | 2.8 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 2.8 | REACTOME HOST INTERACTIONS OF HIV FACTORS | Genes involved in Host Interactions of HIV factors |