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Illumina Body Map 2: averaged replicates
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Results for RCOR1_MTA3
Z-value: 2.89
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Transcription factors associated with RCOR1_MTA3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RCOR1 | hg19_v2_chr14_+_103058948_103059005 | -0.37 | 3.7e-02 | Click! |
| MTA3 | hg19_v2_chr2_+_42721689_42721723 | 0.22 | 2.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RCOR1_MTA3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 53.4 | GO:2000257 | regulation of protein activation cascade(GO:2000257) |
| 0.9 | 47.7 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 1.3 | 46.5 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.6 | 37.6 | GO:0090382 | phagosome maturation(GO:0090382) |
| 0.9 | 33.8 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.2 | 33.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.5 | 32.2 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.7 | 30.3 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.7 | 29.3 | GO:0035640 | exploration behavior(GO:0035640) |
| 1.5 | 27.8 | GO:0015812 | gamma-aminobutyric acid transport(GO:0015812) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 545.2 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 468.4 | GO:1903561 | extracellular vesicle(GO:1903561) |
| 0.2 | 190.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.4 | 134.0 | GO:0098793 | presynapse(GO:0098793) |
| 0.4 | 133.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.2 | 127.4 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.4 | 115.1 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.3 | 96.2 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.8 | 81.4 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.2 | 58.9 | GO:0043025 | neuronal cell body(GO:0043025) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 59.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.5 | 52.4 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.1 | 47.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 40.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.8 | 38.1 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.8 | 37.7 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.2 | 34.2 | GO:0005525 | GTP binding(GO:0005525) |
| 0.7 | 29.1 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.8 | 28.4 | GO:0031489 | myosin V binding(GO:0031489) |
| 1.4 | 27.3 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 50.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.4 | 38.5 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 37.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 36.5 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.4 | 35.5 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.2 | 30.0 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.5 | 29.8 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.4 | 29.4 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.4 | 24.3 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.4 | 24.3 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 95.6 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.3 | 59.7 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.3 | 53.7 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.7 | 48.9 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 1.0 | 47.3 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 1.2 | 45.5 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.4 | 39.8 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.2 | 39.1 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 1.3 | 37.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.7 | 34.8 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |