Project
Illumina Body Map 2: averaged replicates
Navigation
Downloads
Results for REL
Z-value: 1.87
Motif logo
Transcription factors associated with REL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| REL | hg19_v2_chr2_+_61108771_61108791 | 0.15 | 4.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_90077680 Show fit | 4.86 |
ENST00000390270.2
|
immunoglobulin kappa variable 3D-20 |
|
| chr2_+_90153696 Show fit | 3.98 |
ENST00000417279.2
|
immunoglobulin kappa variable 3D-15 (gene/pseudogene) |
|
| chr22_+_22712087 Show fit | 3.97 |
ENST00000390294.2
|
immunoglobulin lambda variable 1-47 |
|
| chr22_-_19512893 Show fit | 3.74 |
ENST00000403084.1
ENST00000413119.2 |
claudin 5 |
|
| chr2_-_89247338 Show fit | 3.72 |
ENST00000496168.1
|
immunoglobulin kappa variable 1-5 |
|
| chr6_+_138188378 Show fit | 3.47 |
ENST00000420009.1
|
tumor necrosis factor, alpha-induced protein 3 |
|
| chr14_-_106610852 Show fit | 3.47 |
ENST00000390603.2
|
immunoglobulin heavy variable 3-15 |
|
| chr2_-_89310012 Show fit | 3.44 |
ENST00000493819.1
|
immunoglobulin kappa variable 1-9 |
|
| chr8_-_23712312 Show fit | 3.36 |
ENST00000290271.2
|
stanniocalcin 1 |
|
| chr6_+_138188351 Show fit | 3.16 |
ENST00000421450.1
|
tumor necrosis factor, alpha-induced protein 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of REL
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 3.2 | 9.6 | GO:0072573 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) |
| 0.0 | 7.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 5.6 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.1 | 5.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 4.4 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.3 | 4.1 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 1.0 | 3.8 | GO:0014859 | negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723) |
| 0.3 | 3.7 | GO:1903142 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 0.3 | 3.2 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.1 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 8.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 8.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.5 | 5.3 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.1 | 5.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 4.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 4.4 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.2 | 4.1 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.1 | 3.8 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 3.5 | GO:0002102 | podosome(GO:0002102) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 32.2 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 10.6 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.5 | 9.0 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 5.9 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.1 | 5.2 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.3 | 5.1 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 4.8 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 4.4 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 3.4 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 3.3 | GO:0050699 | WW domain binding(GO:0050699) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.0 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.2 | 5.9 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 5.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 4.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.9 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 3.9 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 3.0 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 2.9 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.1 | 2.9 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 2.9 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.6 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 8.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 5.4 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 4.1 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 3.7 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 3.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 3.6 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.1 | 3.1 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.1 | 2.7 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 2.7 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |