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Illumina Body Map 2: averaged replicates
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Results for REST
Z-value: 6.59
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Transcription factors associated with REST
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| REST | hg19_v2_chr4_+_57774042_57774114 | -0.18 | 3.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of REST
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 141.1 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 19.6 | 58.9 | GO:0048174 | negative regulation of short-term neuronal synaptic plasticity(GO:0048174) |
| 6.2 | 55.8 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 1.9 | 53.1 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.8 | 48.6 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 6.6 | 46.0 | GO:0006540 | glutamate decarboxylation to succinate(GO:0006540) |
| 9.1 | 45.6 | GO:0007198 | adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198) |
| 12.3 | 37.0 | GO:0040040 | thermosensory behavior(GO:0040040) |
| 1.1 | 33.3 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 7.2 | 29.0 | GO:0035544 | negative regulation of SNARE complex assembly(GO:0035544) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 126.1 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 123.1 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.3 | 71.3 | GO:0098793 | presynapse(GO:0098793) |
| 0.1 | 63.2 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 11.8 | 58.9 | GO:0032127 | dense core granule membrane(GO:0032127) |
| 0.4 | 55.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 5.3 | 53.1 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 2.4 | 51.8 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 6.9 | 48.6 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 0.4 | 45.6 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 83.4 | GO:0008430 | selenium binding(GO:0008430) |
| 0.6 | 73.5 | GO:0019905 | syntaxin binding(GO:0019905) |
| 1.8 | 66.5 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 5.4 | 58.9 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 3.3 | 55.8 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 1.2 | 53.1 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 2.6 | 48.6 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 5.8 | 46.0 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 3.5 | 45.6 | GO:0051378 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
| 0.0 | 41.1 | GO:0019900 | kinase binding(GO:0019900) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 48.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 25.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.4 | 23.9 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 14.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 12.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 10.8 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 10.5 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 2.3 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 73.2 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.3 | 51.0 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 1.0 | 46.0 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 2.9 | 45.6 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.3 | 39.1 | REACTOME REGULATION OF INSULIN SECRETION | Genes involved in Regulation of Insulin Secretion |
| 0.6 | 32.3 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 29.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.0 | 18.4 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 16.2 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.4 | 15.4 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |