ISMARA results: RFX3

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Illumina Body Map 2: averaged replicates

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Results for RFX3_RFX2

Z-value: 10.18

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Transcription factors associated with RFX3_RFX2

Gene Symbol	Gene ID	Gene Info
RFX3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000080298.11	regulatory factor X3
RFX2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000087903.8	regulatory factor X2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RFX2	hg19_v2_chr19_-_6199521_6199546	0.74	1.4e-06	Click!
RFX3	hg19_v2_chr9_-_3489428_3489437	0.60	2.6e-04	Click!

Activity profile of RFX3_RFX2 motif

Sorted Z-values of RFX3_RFX2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_109656439 Show fit	37.05	ENST00000369949.4	C1orf194 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 1 open reading frame 194
chr21_-_43916296 Show fit	30.70	ENST00000398352.3	RSPH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	radial spoke head 1 homolog (Chlamydomonas)
chr21_-_43916433 Show fit	29.91	ENST00000291536.3	RSPH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	radial spoke head 1 homolog (Chlamydomonas)
chr1_-_169396666 Show fit	29.38	ENST00000456107.1 ENST00000367805.3	CCDC181 Ensembl NCBI GeneCards UniProt NextProt Show fit	coiled-coil domain containing 181
chr1_-_169396646 Show fit	28.04	ENST00000367806.3	CCDC181 Ensembl NCBI GeneCards UniProt NextProt Show fit	coiled-coil domain containing 181
chr1_-_159869912 Show fit	22.71	ENST00000368099.4	CCDC19 Ensembl NCBI GeneCards UniProt NextProt Show fit	coiled-coil domain containing 19
chr5_+_34839260 Show fit	22.51	ENST00000505624.1	TTC23L Ensembl NCBI GeneCards UniProt NextProt Show fit	tetratricopeptide repeat domain 23-like
chr3_-_167098059 Show fit	21.68	ENST00000392764.1 ENST00000474464.1 ENST00000392766.2 ENST00000485651.1	ZBBX Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger, B-box domain containing
chr17_+_9479944 Show fit	21.66	ENST00000396219.3 ENST00000352665.5	WDR16 Ensembl NCBI GeneCards UniProt NextProt Show fit	WD repeat domain 16
chr16_+_84178874 Show fit	20.30	ENST00000378553.5	DNAAF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	dynein, axonemal, assembly factor 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX3_RFX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	117.6	GO:0035082	axoneme assembly(GO:0035082)
0.3	55.8	GO:0048813	dendrite morphogenesis(GO:0048813)
2.1	50.9	GO:0003341	cilium movement(GO:0003341)
4.7	41.9	GO:0035469	determination of pancreatic left/right asymmetry(GO:0035469)
2.5	41.8	GO:0060294	cilium movement involved in cell motility(GO:0060294)
0.2	37.0	GO:0009566	fertilization(GO:0009566)
0.8	32.6	GO:0007141	male meiosis I(GO:0007141)
2.7	31.9	GO:0036159	inner dynein arm assembly(GO:0036159)
0.2	31.8	GO:0018107	peptidyl-threonine phosphorylation(GO:0018107)
2.2	31.0	GO:0007258	JUN phosphorylation(GO:0007258)

Showing 1 to 10 of 209 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	171.1	GO:0005930	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.2	105.1	GO:0005874	microtubule(GO:0005874)
0.6	85.5	GO:0001669	acrosomal vesicle(GO:0001669)
8.7	69.7	GO:0002177	manchette(GO:0002177)
0.7	69.2	GO:0036126	sperm flagellum(GO:0036126)
0.1	67.1	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
4.3	60.6	GO:0072687	meiotic spindle(GO:0072687)
0.1	45.9	GO:0005929	cilium(GO:0005929)
0.5	42.2	GO:0005871	kinesin complex(GO:0005871)
6.5	32.6	GO:0097123	cyclin A1-CDK2 complex(GO:0097123)

Showing 1 to 10 of 89 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	151.1	GO:0008017	microtubule binding(GO:0008017)
0.1	64.2	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.7	52.8	GO:0003777	microtubule motor activity(GO:0003777)
0.7	36.0	GO:0070840	dynein complex binding(GO:0070840)
1.5	35.4	GO:0045504	dynein heavy chain binding(GO:0045504)
0.1	33.3	GO:0003924	GTPase activity(GO:0003924)
2.6	31.0	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1	27.3	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.2	26.3	GO:0008013	beta-catenin binding(GO:0008013)
1.0	26.0	GO:0045505	dynein intermediate chain binding(GO:0045505)

Showing 1 to 10 of 141 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	44.5	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
1.0	28.2	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4	20.8	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2	16.4	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.2	11.8	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.2	11.5	PID EPHA FWDPATHWAY	EPHA forward signaling
0.1	11.4	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.1	10.2	PID AURORA B PATHWAY	Aurora B signaling
0.1	8.6	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.1	8.5	PID CERAMIDE PATHWAY	Ceramide signaling pathway

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	40.9	REACTOME KINESINS	Genes involved in Kinesins
1.1	32.6	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1	28.8	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2	28.0	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.9	26.9	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.1	25.9	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.5	21.3	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.6	18.5	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.3	18.5	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.3	14.4	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Showing 1 to 10 of 47 entries

Results for RFX3_RFX2

Z-value: 10.18

Motif logo

Transcription factors associated with RFX3_RFX2

Activity-expression correlation:

Activity profile of RFX3_RFX2 motif

Sorted Z-values of RFX3_RFX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX3_RFX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: