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Illumina Body Map 2: averaged replicates

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Results for RFX5

Z-value: 1.48

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Transcription factors associated with RFX5

Gene Symbol Gene ID Gene Info
RFX5
ENSG00000143390.13 regulatory factor X5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX5hg19_v2_chr1_-_151319283_1513193140.411.8e-02Click!

Activity profile of RFX5 motif

Sorted Z-values of RFX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_142020496 4.98 ENST00000390381.3
TRBV5-1
T cell receptor beta variable 5-1
chr6_-_32784687 4.59 ENST00000447394.1
ENST00000438763.2
HLA-DOB
major histocompatibility complex, class II, DO beta
chr22_+_44576770 4.56 ENST00000444313.3
ENST00000416291.1
PARVG
parvin, gamma
chr6_-_32731243 4.10 ENST00000427449.1
ENST00000411527.1
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr6_-_32498046 3.89 ENST00000374975.3
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr22_+_44577237 3.59 ENST00000415224.1
ENST00000417767.1
PARVG
parvin, gamma
chr6_-_32634425 3.58 ENST00000399082.3
ENST00000399079.3
ENST00000374943.4
ENST00000434651.2
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr6_-_32731299 3.56 ENST00000435145.2
ENST00000437316.2
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr6_-_32908765 2.86 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr6_-_32908792 2.76 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr6_+_33043703 2.72 ENST00000418931.2
ENST00000535465.1
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr6_-_32557610 2.71 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr5_-_149792295 2.59 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_-_30658745 2.58 ENST00000376420.5
ENST00000376421.5
NRM
nurim (nuclear envelope membrane protein)
chr6_-_32920794 2.48 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
HLA-DMA
XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha
Uncharacterized protein
chr6_-_133079022 2.34 ENST00000525289.1
ENST00000326499.6
VNN2
vanin 2
chr6_+_32812568 2.25 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32821599 2.25 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_+_26383318 2.24 ENST00000469230.1
ENST00000490025.1
ENST00000356709.4
ENST00000352867.2
ENST00000493275.1
ENST00000472507.1
ENST00000482536.1
ENST00000432533.2
ENST00000482842.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr6_+_26383404 2.13 ENST00000416795.2
ENST00000494184.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr2_-_242088850 2.09 ENST00000358649.4
ENST00000452907.1
ENST00000403638.3
ENST00000539818.1
ENST00000415234.1
ENST00000234040.4
PASK
PAS domain containing serine/threonine kinase
chr6_-_32812420 1.92 ENST00000374881.2
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr6_+_32821924 1.80 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr13_-_47012325 1.65 ENST00000409879.2
KIAA0226L
KIAA0226-like
chr15_+_45003675 1.56 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
B2M
beta-2-microglobulin
chr6_+_26458171 1.47 ENST00000493173.1
ENST00000541522.1
ENST00000429381.1
ENST00000469185.1
BTN2A1
butyrophilin, subfamily 2, member A1
chr4_-_143227088 1.45 ENST00000511838.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr19_+_19496624 1.42 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
GATAD2A
GATA zinc finger domain containing 2A
chr6_+_26458152 1.42 ENST00000312541.5
BTN2A1
butyrophilin, subfamily 2, member A1
chr4_-_143226979 1.41 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr1_+_181003067 1.28 ENST00000434571.2
ENST00000367579.3
ENST00000282990.6
ENST00000367580.5
MR1
major histocompatibility complex, class I-related
chr6_+_26365443 1.20 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr19_-_49118067 1.08 ENST00000593772.1
FAM83E
family with sequence similarity 83, member E
chr3_+_196466710 1.08 ENST00000327134.3
PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr6_+_26365387 1.03 ENST00000532865.1
ENST00000530653.1
ENST00000527417.1
BTN3A2
butyrophilin, subfamily 3, member A2
chr11_-_6640585 1.01 ENST00000533371.1
ENST00000528657.1
ENST00000436873.2
ENST00000299427.6
TPP1
tripeptidyl peptidase I
chr19_+_19496728 0.96 ENST00000537887.1
ENST00000417582.2
GATAD2A
GATA zinc finger domain containing 2A
chr6_+_26440700 0.92 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr3_+_43328004 0.92 ENST00000454177.1
ENST00000429705.2
ENST00000296088.7
ENST00000437827.1
SNRK
SNF related kinase
chr11_+_8008867 0.92 ENST00000309828.4
ENST00000449102.2
EIF3F
eukaryotic translation initiation factor 3, subunit F
chr1_+_249132462 0.90 ENST00000306562.3
ZNF672
zinc finger protein 672
chr1_-_53608249 0.89 ENST00000371494.4
SLC1A7
solute carrier family 1 (glutamate transporter), member 7
chr11_-_85430088 0.81 ENST00000533057.1
ENST00000533892.1
SYTL2
synaptotagmin-like 2
chr19_-_51014345 0.72 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
JOSD2
Josephin domain containing 2
chr11_+_111385497 0.68 ENST00000375618.4
ENST00000529167.1
ENST00000332814.6
C11orf88
chromosome 11 open reading frame 88
chr8_+_101170257 0.65 ENST00000251809.3
SPAG1
sperm associated antigen 1
chr1_+_114473350 0.61 ENST00000503968.1
HIPK1
homeodomain interacting protein kinase 1
chr1_+_249132512 0.61 ENST00000505503.1
ZNF672
zinc finger protein 672
chr16_+_67381263 0.53 ENST00000541146.1
ENST00000563189.1
ENST00000290940.7
LRRC36
leucine rich repeat containing 36
chr17_+_27052892 0.50 ENST00000579671.1
ENST00000579060.1
NEK8
NIMA-related kinase 8
chr19_-_6057282 0.50 ENST00000592281.1
RFX2
regulatory factor X, 2 (influences HLA class II expression)
chr9_+_43135095 0.48 ENST00000377437.2
AL513478.1
Uncharacterized protein
chr5_+_119799927 0.46 ENST00000407149.2
ENST00000379551.2
PRR16
proline rich 16
chr19_+_36103631 0.40 ENST00000203166.5
ENST00000379045.2
HAUS5
HAUS augmin-like complex, subunit 5
chr1_-_208417620 0.33 ENST00000367033.3
PLXNA2
plexin A2
chr7_+_766320 0.29 ENST00000297440.6
ENST00000313147.5
HEATR2
HEAT repeat containing 2
chr16_+_67381289 0.28 ENST00000435835.3
LRRC36
leucine rich repeat containing 36
chr9_-_67925210 0.27 ENST00000543078.1
BX649567.1
Uncharacterized protein
chr4_+_88529681 0.27 ENST00000399271.1
DSPP
dentin sialophosphoprotein
chr5_-_55412774 0.25 ENST00000434982.2
ANKRD55
ankyrin repeat domain 55
chr3_+_9851384 0.19 ENST00000419081.1
ENST00000438596.1
ENST00000417065.1
ENST00000439814.1
ENST00000418745.1
TTLL3
tubulin tyrosine ligase-like family, member 3
chr12_-_123565834 0.13 ENST00000546049.1
PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr10_+_82116529 0.12 ENST00000411538.1
ENST00000256039.2
DYDC2
DPY30 domain containing 2
chr8_-_99306611 0.11 ENST00000341166.3
NIPAL2
NIPA-like domain containing 2
chr10_+_14880287 0.07 ENST00000437161.2
HSPA14
heat shock 70kDa protein 14
chr17_+_30348024 0.06 ENST00000327564.7
ENST00000584368.1
ENST00000394713.3
ENST00000341671.7
LRRC37B
leucine rich repeat containing 37B
chr7_-_15014398 0.06 ENST00000437998.1
DGKB
diacylglycerol kinase, beta 90kDa
chr10_+_14880157 0.01 ENST00000378372.3
HSPA14
heat shock 70kDa protein 14
chr22_-_30987837 0.01 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 10.8 GO:0002399 MHC class II protein complex assembly(GO:0002399)
1.5 4.6 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.8 1.6 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
0.6 2.2 GO:0046967 cytosol to ER transport(GO:0046967)
0.5 2.6 GO:0002906 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.3 2.1 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.2 4.4 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.2 1.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 2.3 GO:0015939 pantothenate metabolic process(GO:0015939)
0.1 17.8 GO:0031295 T cell costimulation(GO:0031295)
0.1 0.3 GO:0021934 hindbrain tangential cell migration(GO:0021934)
0.1 2.2 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.8 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 5.8 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.6 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.9 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 2.9 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 1.3 GO:0032620 interleukin-17 production(GO:0032620)
0.0 7.3 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.5 GO:0035330 regulation of hippo signaling(GO:0035330)
0.0 0.8 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.5 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.5 GO:0001675 acrosome assembly(GO:0001675)
0.0 2.4 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 1.0 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.7 GO:0048741 skeletal muscle fiber development(GO:0048741)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 35.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.7 6.0 GO:1990111 spermatoproteasome complex(GO:1990111)
0.3 2.2 GO:0042825 TAP complex(GO:0042825)
0.3 1.6 GO:0031905 early endosome lumen(GO:0031905)
0.2 0.5 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 1.3 GO:0042611 MHC protein complex(GO:0042611)
0.1 0.9 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 2.4 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.4 GO:0070652 HAUS complex(GO:0070652)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 2.6 GO:0005637 nuclear inner membrane(GO:0005637)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 15.8 GO:0032395 MHC class II receptor activity(GO:0032395)
0.5 2.6 GO:0042289 MHC class II protein binding(GO:0042289)
0.5 2.9 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.4 2.3 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.3 11.6 GO:0042605 peptide antigen binding(GO:0042605)
0.3 8.1 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.2 6.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.0 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.1 1.3 GO:0032393 MHC class I receptor activity(GO:0032393)
0.1 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.8 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.1 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.9 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 8.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 2.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.6 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.1 PID MYC PATHWAY C-MYC pathway
0.0 2.4 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 9.3 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 1.6 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 2.9 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 8.1 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.1 15.3 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 1.1 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.8 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)