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Illumina Body Map 2: averaged replicates

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Results for RORC

Z-value: 0.94

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Transcription factors associated with RORC

Gene Symbol Gene ID Gene Info
RORC
ENSG00000143365.12 RAR related orphan receptor C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RORChg19_v2_chr1_-_151804222_151804228-0.086.5e-01Click!

Activity profile of RORC motif

Sorted Z-values of RORC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_102531717 2.20 ENST00000372680.1
TCEAL5
transcription elongation factor A (SII)-like 5
chr20_+_37209820 2.13 ENST00000537425.1
ENST00000373348.3
ENST00000416116.1
ADIG
adipogenin
chr20_-_23433471 1.80 ENST00000377009.3
CST11
cystatin 11
chrX_-_43832711 1.73 ENST00000378062.5
NDP
Norrie disease (pseudoglioma)
chr20_-_23433494 1.70 ENST00000377007.3
CST11
cystatin 11
chr1_-_240906911 1.69 ENST00000431139.2
RP11-80B9.4
RP11-80B9.4
chr11_-_19223523 1.53 ENST00000265968.3
CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr7_-_141541221 1.53 ENST00000350549.3
ENST00000438520.1
PRSS37
protease, serine, 37
chr17_-_10707410 1.36 ENST00000581851.1
LINC00675
long intergenic non-protein coding RNA 675
chr11_-_64527425 1.34 ENST00000377432.3
PYGM
phosphorylase, glycogen, muscle
chrX_+_69501943 1.21 ENST00000509895.1
ENST00000374473.2
ENST00000276066.4
RAB41
RAB41, member RAS oncogene family
chr18_-_31603603 1.20 ENST00000586553.1
NOL4
nucleolar protein 4
chr3_-_42452050 1.17 ENST00000441172.1
ENST00000287748.3
LYZL4
lysozyme-like 4
chr19_+_38924316 1.16 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
RYR1
ryanodine receptor 1 (skeletal)
chr13_+_109248500 1.14 ENST00000356711.2
MYO16
myosin XVI
chr17_-_42992856 1.11 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
GFAP
glial fibrillary acidic protein
chr3_-_117716418 1.07 ENST00000484092.1
RP11-384F7.2
RP11-384F7.2
chr19_-_7697857 1.05 ENST00000598935.1
PCP2
Purkinje cell protein 2
chr1_+_236849754 1.03 ENST00000542672.1
ENST00000366578.4
ACTN2
actinin, alpha 2
chr19_-_7698599 0.95 ENST00000311069.5
PCP2
Purkinje cell protein 2
chr20_-_44007014 0.95 ENST00000372726.3
ENST00000537995.1
TP53TG5
TP53 target 5
chr14_+_21785693 0.92 ENST00000382933.4
ENST00000557351.1
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr3_-_164914640 0.82 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr12_-_82152420 0.72 ENST00000552948.1
ENST00000548586.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr21_+_17553910 0.67 ENST00000428669.2
LINC00478
long intergenic non-protein coding RNA 478
chr1_+_154540246 0.66 ENST00000368476.3
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr11_-_47616210 0.65 ENST00000302514.3
C1QTNF4
C1q and tumor necrosis factor related protein 4
chr19_+_39759154 0.65 ENST00000331982.5
IFNL2
interferon, lambda 2
chr9_-_35042824 0.64 ENST00000595331.1
FLJ00273
FLJ00273
chr19_-_39735646 0.61 ENST00000413851.2
IFNL3
interferon, lambda 3
chr17_-_37764128 0.57 ENST00000302584.4
NEUROD2
neuronal differentiation 2
chr14_+_23025534 0.55 ENST00000557595.1
AE000662.92
Uncharacterized protein
chr4_+_85504075 0.55 ENST00000295887.5
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr4_-_170948361 0.52 ENST00000393702.3
MFAP3L
microfibrillar-associated protein 3-like
chr2_-_30144432 0.50 ENST00000389048.3
ALK
anaplastic lymphoma receptor tyrosine kinase
chr4_-_189923195 0.50 ENST00000508799.1
RP11-818C3.1
RP11-818C3.1
chr3_-_45957534 0.47 ENST00000536047.1
LZTFL1
leucine zipper transcription factor-like 1
chr12_-_82152444 0.47 ENST00000549325.1
ENST00000550584.2
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr16_+_24266874 0.47 ENST00000005284.3
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr17_+_44679808 0.43 ENST00000571172.1
NSF
N-ethylmaleimide-sensitive factor
chr19_-_46580352 0.42 ENST00000601672.1
IGFL4
IGF-like family member 4
chr3_+_185304059 0.41 ENST00000427465.2
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr22_-_32860427 0.41 ENST00000534972.1
ENST00000397450.1
ENST00000397452.1
BPIFC
BPI fold containing family C
chr3_-_45957088 0.41 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr14_-_104408645 0.40 ENST00000557640.1
RD3L
retinal degeneration 3-like
chr4_-_159094194 0.40 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
FAM198B
family with sequence similarity 198, member B
chr7_+_20687017 0.40 ENST00000258738.6
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr10_-_21435488 0.38 ENST00000534331.1
ENST00000529198.1
ENST00000377118.4
C10orf113
chromosome 10 open reading frame 113
chr10_-_105845674 0.36 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr8_-_95449155 0.35 ENST00000481490.2
FSBP
fibrinogen silencer binding protein
chr1_-_157069590 0.27 ENST00000454449.2
ETV3L
ets variant 3-like
chr14_-_68157084 0.24 ENST00000557564.1
RP11-1012A1.4
RP11-1012A1.4
chr10_+_102295616 0.24 ENST00000299163.6
HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr10_-_103578162 0.24 ENST00000361464.3
ENST00000357797.5
ENST00000370094.3
MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr16_+_30937213 0.23 ENST00000427128.1
FBXL19
F-box and leucine-rich repeat protein 19
chr4_+_110749143 0.22 ENST00000317735.4
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr3_+_185303962 0.21 ENST00000296257.5
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr10_-_103578182 0.20 ENST00000439817.1
MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr3_-_184095923 0.20 ENST00000445696.2
ENST00000204615.7
THPO
thrombopoietin
chr10_-_105845536 0.17 ENST00000393211.3
COL17A1
collagen, type XVII, alpha 1
chr16_+_30936971 0.15 ENST00000565690.1
FBXL19
F-box and leucine-rich repeat protein 19
chr5_+_177557997 0.15 ENST00000313386.4
ENST00000515098.1
ENST00000542098.1
ENST00000502814.1
ENST00000507457.1
ENST00000508647.1
RMND5B
required for meiotic nuclear division 5 homolog B (S. cerevisiae)
chr19_-_49140692 0.14 ENST00000222122.5
DBP
D site of albumin promoter (albumin D-box) binding protein
chr2_-_148778323 0.13 ENST00000440042.1
ENST00000535373.1
ENST00000540442.1
ENST00000536575.1
ORC4
origin recognition complex, subunit 4
chr14_-_23755297 0.13 ENST00000357460.5
HOMEZ
homeobox and leucine zipper encoding
chr17_-_59940705 0.12 ENST00000577913.1
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr3_+_160559931 0.11 ENST00000464260.1
ENST00000295839.9
PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr14_-_23103716 0.11 ENST00000540461.1
OR6J1
olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene)
chr1_-_211752073 0.11 ENST00000367001.4
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr17_+_47439733 0.10 ENST00000507337.1
RP11-1079K10.3
RP11-1079K10.3
chr17_-_3030875 0.10 ENST00000328890.2
OR1G1
olfactory receptor, family 1, subfamily G, member 1
chr2_+_20650796 0.10 ENST00000448241.1
AC023137.2
AC023137.2
chr22_-_32022280 0.09 ENST00000442379.1
PISD
phosphatidylserine decarboxylase
chr8_+_66955648 0.09 ENST00000522619.1
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr12_+_56624436 0.08 ENST00000266980.4
ENST00000437277.1
SLC39A5
solute carrier family 39 (zinc transporter), member 5
chr7_+_20686946 0.08 ENST00000443026.2
ENST00000406935.1
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr19_+_1269324 0.08 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
CIRBP
cold inducible RNA binding protein
chrX_-_110655391 0.07 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr11_+_65292884 0.07 ENST00000527009.1
SCYL1
SCY1-like 1 (S. cerevisiae)
chr16_-_67514982 0.07 ENST00000565835.1
ENST00000540149.1
ENST00000290949.3
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr1_-_62190793 0.06 ENST00000371177.2
ENST00000606498.1
TM2D1
TM2 domain containing 1
chr1_+_171810606 0.05 ENST00000358155.4
ENST00000367733.2
ENST00000355305.5
ENST00000367731.1
DNM3
dynamin 3
chr12_-_39734783 0.05 ENST00000552961.1
KIF21A
kinesin family member 21A
chr1_+_205197304 0.03 ENST00000358024.3
TMCC2
transmembrane and coiled-coil domain family 2
chr14_-_104408032 0.03 ENST00000455348.2
RD3L
retinal degeneration 3-like
chr12_+_4671352 0.02 ENST00000542744.1
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr7_+_112063192 0.02 ENST00000005558.4
IFRD1
interferon-related developmental regulator 1
chr2_+_148778570 0.01 ENST00000407073.1
MBD5
methyl-CpG binding domain protein 5
chr12_+_56623827 0.01 ENST00000424625.1
ENST00000419753.1
ENST00000454355.2
ENST00000417965.1
ENST00000436633.1
SLC39A5
solute carrier family 39 (zinc transporter), member 5
chr8_+_124780672 0.01 ENST00000521166.1
ENST00000334705.7
FAM91A1
family with sequence similarity 91, member A1

Network of associatons between targets according to the STRING database.

First level regulatory network of RORC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:1903565 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.3 1.7 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.3 1.0 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.2 1.5 GO:0035995 detection of muscle stretch(GO:0035995)
0.2 0.7 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.1 0.5 GO:0036269 swimming behavior(GO:0036269)
0.1 0.6 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.1 0.5 GO:0048749 compound eye development(GO:0048749)
0.1 1.2 GO:0071313 cellular response to caffeine(GO:0071313)
0.1 1.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 2.1 GO:0050872 white fat cell differentiation(GO:0050872)
0.1 0.2 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.1 0.2 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 1.1 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.0 0.4 GO:0035494 SNARE complex disassembly(GO:0035494)
0.0 3.5 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.0 0.5 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.6 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.1 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.0 1.5 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 1.3 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.7 GO:0002385 mucosal immune response(GO:0002385)
0.0 0.1 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.0 0.1 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 1.2 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.4 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.1 GO:0061687 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0 0.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 1.2 GO:0014047 glutamate secretion(GO:0014047)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:1990425 ryanodine receptor complex(GO:1990425)
0.0 0.1 GO:0034657 GID complex(GO:0034657)
0.0 4.7 GO:0036126 sperm flagellum(GO:0036126)
0.0 1.0 GO:0031143 pseudopodium(GO:0031143)
0.0 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.2 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.1 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.5 GO:0030056 hemidesmosome(GO:0030056)
0.0 2.1 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.3 1.2 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.2 1.0 GO:0010861 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.1 0.5 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) phosphatidate cytidylyltransferase activity(GO:0004605)
0.1 1.5 GO:0031433 telethonin binding(GO:0031433)
0.1 0.6 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 1.2 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.5 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.1 0.5 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.4 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 2.2 GO:0050699 WW domain binding(GO:0050699)
0.0 1.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.7 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 3.1 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.2 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.0 0.1 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.0 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.7 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 1.1 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.9 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.2 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen