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Illumina Body Map 2: averaged replicates
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Results for RUNX3_BCL11A
Z-value: 4.42
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Transcription factors associated with RUNX3_BCL11A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RUNX3 | hg19_v2_chr1_-_25291475_25291511 | 0.91 | 5.9e-13 | Click! |
| BCL11A | hg19_v2_chr2_-_60780607_60780634 | 0.44 | 1.3e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RUNX3_BCL11A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 51.6 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 2.1 | 40.4 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 1.0 | 28.5 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 2.1 | 27.3 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.1 | 24.6 | GO:0038096 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.5 | 24.5 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 3.0 | 24.2 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) |
| 0.8 | 24.1 | GO:0002335 | mature B cell differentiation(GO:0002335) |
| 8.0 | 24.0 | GO:0032829 | regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) |
| 1.0 | 21.7 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 93.5 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.4 | 89.6 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.2 | 62.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 43.2 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.2 | 30.8 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.9 | 26.0 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.2 | 23.6 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 22.1 | GO:0005912 | adherens junction(GO:0005912) |
| 0.1 | 20.4 | GO:0016605 | PML body(GO:0016605) |
| 0.9 | 19.8 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 75.8 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 44.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 4.7 | 42.3 | GO:0070891 | lipoteichoic acid binding(GO:0070891) |
| 0.1 | 37.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.0 | 28.5 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.4 | 27.3 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.6 | 24.9 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.6 | 21.2 | GO:0032041 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.8 | 19.8 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 1.0 | 19.6 | GO:0030284 | estrogen receptor activity(GO:0030284) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 64.5 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 1.3 | 41.9 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.4 | 39.3 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.2 | 32.2 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 29.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.7 | 29.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.3 | 29.1 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.4 | 29.0 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.3 | 27.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 24.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 92.3 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.6 | 46.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 35.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 32.0 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.5 | 27.1 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.4 | 23.7 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.1 | 21.6 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.2 | 21.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 18.9 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.5 | 18.4 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |