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Illumina Body Map 2: averaged replicates
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Results for RXRG
Z-value: 1.68
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Transcription factors associated with RXRG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RXRG | hg19_v2_chr1_-_165414414_165414433 | 0.51 | 2.7e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_54378923 Show fit | 3.58 |
ENST00000303460.4
|
homeobox C10 |
|
| chr19_-_49658641 Show fit | 3.53 |
ENST00000252825.4
|
histidine rich calcium binding protein |
|
| chr12_-_54982420 Show fit | 3.22 |
ENST00000257905.8
|
protein phosphatase 1, regulatory (inhibitor) subunit 1A |
|
| chr16_+_55357672 Show fit | 2.97 |
ENST00000290552.7
|
iroquois homeobox 6 |
|
| chr20_+_43343886 Show fit | 2.91 |
ENST00000190983.4
|
WNT1 inducible signaling pathway protein 2 |
|
| chr7_+_116166331 Show fit | 2.74 |
ENST00000393468.1
ENST00000393467.1 |
caveolin 1, caveolae protein, 22kDa |
|
| chr14_-_38725573 Show fit | 2.73 |
ENST00000342213.2
|
C-type lectin domain family 14, member A |
|
| chr12_+_54378849 Show fit | 2.68 |
ENST00000515593.1
|
homeobox C10 |
|
| chr20_-_44539538 Show fit | 2.46 |
ENST00000372420.1
|
phospholipid transfer protein |
|
| chr15_+_41221536 Show fit | 2.44 |
ENST00000249749.5
|
delta-like 4 (Drosophila) |
Network of associatons between targets according to the STRING database.
First level regulatory network of RXRG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.3 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
| 1.5 | 6.0 | GO:0000412 | histone peptidyl-prolyl isomerization(GO:0000412) |
| 1.9 | 5.6 | GO:1901899 | positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081) |
| 1.7 | 5.0 | GO:1900085 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 0.6 | 5.0 | GO:0010732 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.6 | 4.8 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
| 0.0 | 4.8 | GO:0005977 | glycogen metabolic process(GO:0005977) |
| 0.9 | 4.5 | GO:0075509 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
| 0.0 | 4.0 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
| 0.0 | 3.8 | GO:0002027 | regulation of heart rate(GO:0002027) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.5 | 6.3 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.4 | 5.6 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.1 | 5.4 | GO:0031672 | A band(GO:0031672) |
| 0.0 | 5.3 | GO:0042383 | sarcolemma(GO:0042383) |
| 0.3 | 5.0 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.2 | 5.0 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 4.5 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.0 | 3.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 3.3 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.5 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 6.9 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.1 | 6.6 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.2 | 6.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 6.1 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 5.6 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 1.7 | 5.0 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 0.3 | 4.9 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.1 | 3.6 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 3.6 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 5.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.0 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 3.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.5 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 3.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 2.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 2.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 2.5 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 2.4 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
| 0.1 | 5.4 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 3.6 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.3 | 3.5 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 3.5 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 2.9 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.1 | 2.5 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 2.5 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 2.5 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 2.4 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |