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Illumina Body Map 2: averaged replicates
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Results for SCRT1_SCRT2
Z-value: 2.17
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Transcription factors associated with SCRT1_SCRT2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SCRT1 | hg19_v2_chr8_-_145559943_145559943 | 0.54 | 1.5e-03 | Click! |
| SCRT2 | hg19_v2_chr20_-_656823_656902 | 0.41 | 1.9e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_41258786 Show fit | 10.60 |
ENST00000503431.1
ENST00000284440.4 ENST00000508768.1 ENST00000512788.1 |
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
|
| chr6_+_121756809 Show fit | 7.48 |
ENST00000282561.3
|
gap junction protein, alpha 1, 43kDa |
|
| chr17_+_37784749 Show fit | 6.52 |
ENST00000394265.1
ENST00000394267.2 |
protein phosphatase 1, regulatory (inhibitor) subunit 1B |
|
| chr1_+_16083098 Show fit | 5.97 |
ENST00000496928.2
ENST00000508310.1 |
filamin binding LIM protein 1 |
|
| chr1_+_16083154 Show fit | 5.94 |
ENST00000375771.1
|
filamin binding LIM protein 1 |
|
| chr3_+_181429704 Show fit | 5.91 |
ENST00000431565.2
ENST00000325404.1 |
SRY (sex determining region Y)-box 2 |
|
| chr15_-_30114231 Show fit | 5.77 |
ENST00000356107.6
ENST00000545208.2 |
tight junction protein 1 |
|
| chr3_+_16216210 Show fit | 5.55 |
ENST00000437509.1
|
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15 |
|
| chr1_+_16083123 Show fit | 5.43 |
ENST00000510393.1
ENST00000430076.1 |
filamin binding LIM protein 1 |
|
| chr7_-_122526499 Show fit | 5.35 |
ENST00000412584.2
|
Ca++-dependent secretion activator 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SCRT1_SCRT2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 17.3 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 1.6 | 14.7 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
| 3.5 | 10.6 | GO:0007412 | axon target recognition(GO:0007412) |
| 2.6 | 10.5 | GO:1901350 | cell-cell signaling involved in cell-cell junction organization(GO:1901350) |
| 0.1 | 10.3 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 8.3 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 1.9 | 7.5 | GO:0010645 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 0.6 | 6.8 | GO:0001714 | endodermal cell fate specification(GO:0001714) |
| 0.6 | 6.5 | GO:0007621 | negative regulation of female receptivity(GO:0007621) |
| 0.1 | 5.5 | GO:0019933 | cAMP-mediated signaling(GO:0019933) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 17.9 | GO:0005921 | gap junction(GO:0005921) |
| 0.1 | 17.0 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 15.3 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.2 | 13.1 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.1 | 10.4 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 8.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 7.6 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 6.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 5.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.4 | 5.2 | GO:0016013 | syntrophin complex(GO:0016013) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 20.9 | GO:0031005 | filamin binding(GO:0031005) |
| 2.6 | 10.6 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.3 | 10.3 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 9.5 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.8 | 7.5 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 1.3 | 6.5 | GO:0031751 | D4 dopamine receptor binding(GO:0031751) |
| 0.2 | 5.9 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.0 | 5.9 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 5.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 5.5 | GO:0030552 | cAMP binding(GO:0030552) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.6 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 10.5 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 7.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 7.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 5.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 4.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 4.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 2.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 2.1 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 17.0 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.4 | 10.5 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.3 | 7.5 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 6.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 5.9 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 5.3 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 4.7 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 4.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 4.4 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 4.4 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |