ISMARA results: SIN3A

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Illumina Body Map 2: averaged replicates

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Results for SIN3A_CHD1

Z-value: 2.66

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Transcription factors associated with SIN3A_CHD1

Gene Symbol	Gene ID	Gene Info
SIN3A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000169375.11	SIN3 transcription regulator family member A
CHD1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000153922.6	chromodomain helicase DNA binding protein 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SIN3A	hg19_v2_chr15_-_75748115_75748126	0.47	6.5e-03	Click!
CHD1	hg19_v2_chr5_-_98262240_98262240	0.27	1.4e-01	Click!

Activity profile of SIN3A_CHD1 motif

Sorted Z-values of SIN3A_CHD1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_+_589893 Show fit	6.26	ENST00000251287.2	HCN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr14_+_29236269 Show fit	5.00	ENST00000313071.4	FOXG1 Ensembl NCBI GeneCards UniProt NextProt Show fit	forkhead box G1
chr17_+_54671047 Show fit	4.98	ENST00000332822.4	NOG Ensembl NCBI GeneCards UniProt NextProt Show fit	noggin
chr5_-_16179884 Show fit	4.52	ENST00000332432.8	MARCH11 Ensembl NCBI GeneCards UniProt NextProt Show fit	membrane-associated ring finger (C3HC4) 11
chr9_-_92112953 Show fit	4.12	ENST00000339861.4 ENST00000422704.2 ENST00000455551.2	SEMA4D Ensembl NCBI GeneCards UniProt NextProt Show fit	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chr2_+_105471969 Show fit	4.09	ENST00000361360.2	POU3F3 Ensembl NCBI GeneCards UniProt NextProt Show fit	POU class 3 homeobox 3
chr6_+_73331520 Show fit	3.76	ENST00000342056.2 ENST00000355194.4	KCNQ5 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium voltage-gated channel, KQT-like subfamily, member 5
chr19_-_55658281 Show fit	3.73	ENST00000585321.2 ENST00000587465.2	TNNT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	troponin T type 1 (skeletal, slow)
chr16_+_87636474 Show fit	3.66	ENST00000284262.2	JPH3 Ensembl NCBI GeneCards UniProt NextProt Show fit	junctophilin 3
chrX_+_72223352 Show fit	3.64	ENST00000373521.2 ENST00000538388.1	PABPC1L2B Ensembl NCBI GeneCards UniProt NextProt Show fit	poly(A) binding protein, cytoplasmic 1-like 2B

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SIN3A_CHD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	24.3	GO:0000209	protein polyubiquitination(GO:0000209)
0.1	24.0	GO:0071804	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.4	14.7	GO:0048268	clathrin coat assembly(GO:0048268)
0.6	13.9	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.3	13.1	GO:2000300	regulation of synaptic vesicle exocytosis(GO:2000300)
0.2	11.6	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1	10.5	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	9.6	GO:0016567	protein ubiquitination(GO:0016567)
0.4	9.0	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)
0.5	8.8	GO:0021942	radial glia guided migration of Purkinje cell(GO:0021942)

Showing 1 to 10 of 984 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	25.2	GO:0043204	perikaryon(GO:0043204)
0.1	24.7	GO:0098793	presynapse(GO:0098793)
0.2	21.3	GO:0030118	clathrin coat(GO:0030118)
0.1	20.1	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	19.0	GO:0016607	nuclear speck(GO:0016607)
0.1	14.1	GO:0014069	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1	13.0	GO:0016605	PML body(GO:0016605)
0.2	12.4	GO:0048786	presynaptic active zone(GO:0048786)
0.2	12.4	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.2	11.8	GO:0005834	heterotrimeric G-protein complex(GO:0005834)

Showing 1 to 10 of 391 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	28.9	GO:0042393	histone binding(GO:0042393)
0.1	18.9	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.1	18.5	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.1	15.9	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1	11.8	GO:0003777	microtubule motor activity(GO:0003777)
0.0	10.9	GO:0004674	protein serine/threonine kinase activity(GO:0004674)
0.8	10.6	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.3	10.2	GO:0050811	GABA receptor binding(GO:0050811)
0.1	10.0	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	9.4	GO:0017137	Rab GTPase binding(GO:0017137)

Showing 1 to 10 of 537 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	16.5	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.2	15.6	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	14.8	PID NOTCH PATHWAY	Notch signaling pathway
0.2	12.8	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.2	12.8	PID IFNG PATHWAY	IFN-gamma pathway
0.1	12.2	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.3	9.4	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	8.9	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.1	7.8	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.1	7.7	PID AURORA A PATHWAY	Aurora A signaling

Showing 1 to 10 of 75 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	27.0	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.1	23.3	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2	16.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	12.4	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3	12.0	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.1	10.8	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.1	10.7	REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	Genes involved in Transmission across Chemical Synapses
0.0	9.4	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.2	9.0	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.2	8.6	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling

Showing 1 to 10 of 142 entries

Results for SIN3A_CHD1

Z-value: 2.66

Motif logo

Transcription factors associated with SIN3A_CHD1

Activity-expression correlation:

Activity profile of SIN3A_CHD1 motif

Sorted Z-values of SIN3A_CHD1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SIN3A_CHD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: