Project
Illumina Body Map 2: averaged replicates
Navigation
Downloads
Results for SIX1_SIX3_SIX2
Z-value: 1.56
Motif logo
Transcription factors associated with SIX1_SIX3_SIX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SIX2 | hg19_v2_chr2_-_45236540_45236577 | -0.57 | 6.4e-04 | Click! |
| SIX1 | hg19_v2_chr14_-_61116168_61116180 | -0.41 | 2.1e-02 | Click! |
| SIX3 | hg19_v2_chr2_+_45168875_45168916 | 0.04 | 8.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_46679144 Show fit | 6.70 |
ENST00000181383.4
|
carboxypeptidase B2 (plasma) |
|
| chr11_-_58499434 Show fit | 6.69 |
ENST00000344743.3
ENST00000278400.3 |
glycine-N-acyltransferase |
|
| chr13_-_46679185 Show fit | 6.39 |
ENST00000439329.3
|
carboxypeptidase B2 (plasma) |
|
| chr1_+_196946680 Show fit | 5.33 |
ENST00000256785.4
|
complement factor H-related 5 |
|
| chr1_+_196946664 Show fit | 5.32 |
ENST00000367414.5
|
complement factor H-related 5 |
|
| chr6_-_136847099 Show fit | 4.21 |
ENST00000438100.2
|
microtubule-associated protein 7 |
|
| chr2_+_234826016 Show fit | 3.86 |
ENST00000324695.4
ENST00000433712.2 |
transient receptor potential cation channel, subfamily M, member 8 |
|
| chr6_-_136847610 Show fit | 3.48 |
ENST00000454590.1
ENST00000432797.2 |
microtubule-associated protein 7 |
|
| chr3_-_42917363 Show fit | 2.72 |
ENST00000437102.1
|
cytochrome P450, family 8, subfamily B, polypeptide 1 |
|
| chr10_-_33405600 Show fit | 2.59 |
ENST00000414308.1
|
RP11-342D11.3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX1_SIX3_SIX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 13.1 | GO:0003330 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 0.7 | 10.6 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.0 | 6.9 | GO:0006970 | response to osmotic stress(GO:0006970) |
| 0.2 | 6.1 | GO:0006544 | glycine metabolic process(GO:0006544) |
| 0.6 | 4.2 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.6 | 3.9 | GO:0050955 | thermoception(GO:0050955) |
| 0.4 | 3.8 | GO:0030450 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) |
| 1.2 | 3.6 | GO:1903717 | carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718) |
| 0.4 | 3.4 | GO:0071395 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 0.3 | 3.0 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.5 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.0 | 7.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 6.6 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 4.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 3.2 | GO:0044217 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 0.1 | 3.0 | GO:0034385 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.1 | 2.9 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 2.9 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 2.4 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 2.1 | GO:0005577 | fibrinogen complex(GO:0005577) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.9 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.8 | 6.7 | GO:0047961 | glycine N-acyltransferase activity(GO:0047961) |
| 0.0 | 4.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 4.5 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.3 | 4.2 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.1 | 3.9 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.9 | 3.6 | GO:0004088 | carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
| 0.1 | 3.5 | GO:0043495 | protein anchor(GO:0043495) |
| 0.7 | 3.4 | GO:0047023 | androsterone dehydrogenase activity(GO:0047023) |
| 0.1 | 2.4 | GO:0016594 | glycine binding(GO:0016594) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.8 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 3.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 2.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.7 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.3 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 0.4 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 0.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.5 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.0 | 6.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.4 | 5.3 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.1 | 4.5 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.2 | 4.2 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.2 | 3.1 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 2.3 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 2.0 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.1 | 1.9 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 1.7 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |