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Illumina Body Map 2: averaged replicates
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Results for SIX5_SMARCC2_HCFC1
Z-value: 4.86
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Transcription factors associated with SIX5_SMARCC2_HCFC1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000177045.6 | SIX homeobox 5 | |
| ENSG00000139613.7 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 | |
| ENSG00000172534.9 | host cell factor C1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SIX5 | hg19_v2_chr19_-_46272106_46272115 | -0.29 | 1.1e-01 | Click! |
| HCFC1 | hg19_v2_chrX_-_153236819_153236978 | -0.26 | 1.5e-01 | Click! |
| SMARCC2 | hg19_v2_chr12_-_56583243_56583293 | 0.03 | 8.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX5_SMARCC2_HCFC1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 52.2 | GO:0006351 | transcription, DNA-templated(GO:0006351) |
| 0.6 | 26.0 | GO:0042407 | cristae formation(GO:0042407) |
| 0.2 | 19.8 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.8 | 13.9 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.0 | 12.7 | GO:0000086 | G2/M transition of mitotic cell cycle(GO:0000086) |
| 0.1 | 12.4 | GO:0050728 | negative regulation of inflammatory response(GO:0050728) |
| 0.2 | 11.8 | GO:0032008 | positive regulation of TOR signaling(GO:0032008) |
| 0.1 | 11.6 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 10.7 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.0 | 10.0 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 100.0 | GO:0005634 | nucleus(GO:0005634) |
| 0.0 | 46.6 | GO:0005829 | cytosol(GO:0005829) |
| 0.0 | 28.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 23.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 16.6 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.2 | 14.5 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.2 | 14.2 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 12.5 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.1 | 12.3 | GO:0031672 | A band(GO:0031672) |
| 1.3 | 10.4 | GO:0061617 | MICOS complex(GO:0061617) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 41.5 | GO:0003700 | transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.1 | 24.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 23.7 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 21.2 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.1 | 15.1 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 14.4 | GO:0003723 | RNA binding(GO:0003723) |
| 3.5 | 13.9 | GO:0047860 | diiodophenylpyruvate reductase activity(GO:0047860) |
| 0.3 | 12.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.8 | 9.8 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.1 | 9.6 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 9.3 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 8.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 8.6 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 7.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 7.6 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 6.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 4.9 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 4.8 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 4.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 35.0 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 32.2 | REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | Genes involved in Recruitment of mitotic centrosome proteins and complexes |
| 0.2 | 18.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 15.1 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.6 | 14.1 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.2 | 8.6 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.3 | 7.3 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.3 | 7.1 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 6.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 6.3 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |