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Illumina Body Map 2: averaged replicates
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Results for SIX6
Z-value: 1.69
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Transcription factors associated with SIX6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SIX6 | hg19_v2_chr14_+_60975644_60975673 | -0.18 | 3.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_88427568 Show fit | 11.73 |
ENST00000393750.3
ENST00000295834.3 |
fatty acid binding protein 1, liver |
|
| chr1_-_161193349 Show fit | 6.30 |
ENST00000469730.2
ENST00000463273.1 ENST00000464492.1 ENST00000367990.3 ENST00000470459.2 ENST00000468465.1 ENST00000463812.1 |
apolipoprotein A-II |
|
| chr9_-_100707116 Show fit | 6.12 |
ENST00000259456.3
|
hemogen |
|
| chr4_-_155511887 Show fit | 5.92 |
ENST00000302053.3
ENST00000403106.3 |
fibrinogen alpha chain |
|
| chr19_-_16008880 Show fit | 5.10 |
ENST00000011989.7
ENST00000221700.6 |
cytochrome P450, family 4, subfamily F, polypeptide 2 |
|
| chr3_+_151531859 Show fit | 4.49 |
ENST00000488869.1
|
arylacetamide deacetylase |
|
| chr1_+_159557607 Show fit | 3.40 |
ENST00000255040.2
|
amyloid P component, serum |
|
| chr6_+_37012607 Show fit | 3.19 |
ENST00000423336.1
|
cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2 |
|
| chr2_+_34935472 Show fit | 3.19 |
ENST00000604250.1
|
AC073218.2 |
|
| chr3_+_151531810 Show fit | 3.19 |
ENST00000232892.7
|
arylacetamide deacetylase |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 11.7 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
| 0.6 | 7.7 | GO:0010898 | positive regulation of triglyceride catabolic process(GO:0010898) |
| 2.1 | 6.3 | GO:2000910 | negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910) |
| 1.5 | 6.0 | GO:0003330 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 0.4 | 5.9 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 1.0 | 5.7 | GO:0015722 | canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823) |
| 0.0 | 5.6 | GO:0045667 | regulation of osteoblast differentiation(GO:0045667) |
| 1.7 | 5.1 | GO:0032304 | negative regulation of icosanoid secretion(GO:0032304) |
| 0.5 | 3.4 | GO:0052199 | negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) |
| 0.0 | 3.2 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 11.7 | GO:0045179 | apical cortex(GO:0045179) |
| 0.4 | 6.3 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.4 | 5.9 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 4.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.9 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.2 | 3.1 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.7 | 2.8 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.5 | 2.8 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) |
| 0.1 | 2.7 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 2.7 | GO:0060170 | ciliary membrane(GO:0060170) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 11.7 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.2 | 7.7 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.6 | 6.4 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 1.6 | 6.3 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.1 | 6.0 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 1.1 | 5.7 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 1.7 | 5.1 | GO:0097259 | tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259) |
| 0.1 | 3.1 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.3 | 3.0 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.1 | 3.0 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 2.8 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 2.5 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.5 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 0.6 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.0 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 6.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.3 | 5.9 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.4 | 5.7 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 5.1 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 4.7 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 3.1 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 2.8 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 1.4 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.2 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |