ISMARA results: SMAD1

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Illumina Body Map 2: averaged replicates

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Results for SMAD1

Z-value: 2.92

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Transcription factors associated with SMAD1

Gene Symbol	Gene ID	Gene Info
SMAD1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000170365.5	SMAD family member 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SMAD1	hg19_v2_chr4_+_146402346_146402563	-0.35	5.1e-02	Click!

Activity profile of SMAD1 motif

Sorted Z-values of SMAD1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_102608306 Show fit	9.43	ENST00000332549.3	IL1R2 Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 1 receptor, type II
chr14_-_106209368 Show fit	7.20	ENST00000390548.2 ENST00000390549.2 ENST00000390542.2	IGHG1 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_+_30484054 Show fit	6.10	ENST00000564118.1 ENST00000454514.2 ENST00000433423.2	ITGAL Ensembl NCBI GeneCards UniProt NextProt Show fit	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr19_-_54784353 Show fit	5.53	ENST00000391746.1	LILRB2 Ensembl NCBI GeneCards UniProt NextProt Show fit	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
chr21_-_46330545 Show fit	5.36	ENST00000320216.6 ENST00000397852.1	ITGB2 Ensembl NCBI GeneCards UniProt NextProt Show fit	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr22_+_22385332 Show fit	5.25	ENST00000390282.2	IGLV4-69 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 4-69
chr19_-_43835582 Show fit	5.00	ENST00000595748.1	CTC-490G23.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	CTC-490G23.2
chr22_+_22676808 Show fit	4.93	ENST00000390290.2	IGLV1-51 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 1-51
chr5_+_54398463 Show fit	4.88	ENST00000274306.6	GZMA Ensembl NCBI GeneCards UniProt NextProt Show fit	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr14_-_106114739 Show fit	4.85	ENST00000460164.1	RP11-731F5.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-731F5.2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	104.8	GO:0006958	complement activation, classical pathway(GO:0006958)
0.1	101.5	GO:0002283	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
1.2	100.7	GO:0006910	phagocytosis, recognition(GO:0006910)
0.4	86.4	GO:0002377	immunoglobulin production(GO:0002377)
0.3	25.9	GO:0006968	cellular defense response(GO:0006968)
0.2	24.8	GO:0060333	interferon-gamma-mediated signaling pathway(GO:0060333)
0.2	17.4	GO:0050853	B cell receptor signaling pathway(GO:0050853)
2.1	16.6	GO:0002774	Fc receptor mediated inhibitory signaling pathway(GO:0002774)
1.2	16.1	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.1	15.1	GO:0050852	T cell receptor signaling pathway(GO:0050852)

Showing 1 to 10 of 1,046 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	96.0	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.2	51.3	GO:0009897	external side of plasma membrane(GO:0009897)
0.2	50.3	GO:0072562	blood microparticle(GO:0072562)
0.3	45.8	GO:0070821	tertiary granule membrane(GO:0070821)
1.0	36.6	GO:0042101	T cell receptor complex(GO:0042101)
0.5	30.3	GO:0001772	immunological synapse(GO:0001772)
0.1	28.9	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1	27.3	GO:0030667	secretory granule membrane(GO:0030667)
2.3	25.1	GO:0034687	integrin alphaL-beta2 complex(GO:0034687)
0.0	20.5	GO:0005615	extracellular space(GO:0005615)

Showing 1 to 10 of 327 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	213.3	GO:0003823	antigen binding(GO:0003823)
1.6	103.5	GO:0034987	immunoglobulin receptor binding(GO:0034987)
2.2	26.4	GO:0030369	ICAM-3 receptor activity(GO:0030369)
0.2	23.6	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.4	22.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.1	22.1	GO:0030246	carbohydrate binding(GO:0030246)
0.2	21.5	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.7	21.2	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	21.1	GO:0000987	core promoter proximal region sequence-specific DNA binding(GO:0000987)
1.1	20.4	GO:0019864	IgG binding(GO:0019864)

Showing 1 to 10 of 635 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	51.2	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.5	51.2	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.3	27.4	PID IL4 2PATHWAY	IL4-mediated signaling events
0.3	26.4	PID BCR 5PATHWAY	BCR signaling pathway
0.4	20.6	PID IL1 PATHWAY	IL1-mediated signaling events
0.6	19.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.5	19.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.5	17.8	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	14.0	PID CMYB PATHWAY	C-MYB transcription factor network
0.3	10.8	PID IL12 2PATHWAY	IL12-mediated signaling events

Showing 1 to 10 of 99 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	85.1	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
1.3	32.5	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.4	29.1	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.3	24.9	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.2	23.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.2	18.3	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
1.3	17.4	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.5	17.3	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.3	14.0	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	13.5	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases

Showing 1 to 10 of 154 entries

Results for SMAD1

Z-value: 2.92

Motif logo

Transcription factors associated with SMAD1

Activity-expression correlation:

Activity profile of SMAD1 motif

Sorted Z-values of SMAD1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: