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Illumina Body Map 2: averaged replicates
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Results for SOX10_SOX15
Z-value: 1.79
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Transcription factors associated with SOX10_SOX15
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX10 | hg19_v2_chr22_-_38380543_38380569 | -0.39 | 2.9e-02 | Click! |
| SOX15 | hg19_v2_chr17_-_7493390_7493488 | -0.38 | 3.2e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX10_SOX15
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.2 | 21.7 | GO:0002728 | negative regulation of natural killer cell cytokine production(GO:0002728) |
| 1.2 | 8.1 | GO:0061152 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
| 0.1 | 7.8 | GO:0006509 | membrane protein ectodomain proteolysis(GO:0006509) |
| 1.0 | 7.7 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 0.1 | 6.7 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
| 0.4 | 6.5 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.3 | 6.3 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 1.0 | 6.2 | GO:1904209 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.2 | 5.4 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.1 | 5.3 | GO:0006376 | mRNA splice site selection(GO:0006376) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 10.9 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.7 | 9.8 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.1 | 8.5 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 5.6 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 5.3 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 5.2 | GO:0036464 | cytoplasmic ribonucleoprotein granule(GO:0036464) |
| 0.0 | 4.9 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 4.7 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 4.6 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 0.0 | 4.5 | GO:0072562 | blood microparticle(GO:0072562) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 10.2 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 8.5 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.4 | 8.1 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.0 | 7.3 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 6.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.6 | 6.3 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.1 | 6.2 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.0 | 5.9 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 5.6 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 5.4 | GO:0036002 | pre-mRNA binding(GO:0036002) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 6.9 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 6.7 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 6.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 5.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 4.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 4.2 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 3.7 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 3.4 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 2.7 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.7 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 6.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 5.3 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 4.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 4.1 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 4.0 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 2.8 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 2.7 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 2.7 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 2.5 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |