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Illumina Body Map 2: averaged replicates
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Results for SOX13_SOX12
Z-value: 1.88
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Transcription factors associated with SOX13_SOX12
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX12 | hg19_v2_chr20_+_306177_306211 | 0.18 | 3.3e-01 | Click! |
| SOX13 | hg19_v2_chr1_+_204042723_204042784 | 0.11 | 5.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_10573149 Show fit | 5.01 |
ENST00000381904.2
ENST00000381903.2 ENST00000396439.2 |
killer cell lectin-like receptor subfamily C, member 3 |
|
| chr6_-_49712091 Show fit | 4.39 |
ENST00000371159.4
|
cysteine-rich secretory protein 3 |
|
| chr6_-_49712123 Show fit | 4.22 |
ENST00000263045.4
|
cysteine-rich secretory protein 3 |
|
| chr6_-_49712147 Show fit | 3.96 |
ENST00000433368.2
ENST00000354620.4 |
cysteine-rich secretory protein 3 |
|
| chr6_-_49712072 Show fit | 3.80 |
ENST00000423399.2
|
cysteine-rich secretory protein 3 |
|
| chr12_-_11463353 Show fit | 3.42 |
ENST00000279575.1
ENST00000535904.1 ENST00000445719.2 |
proline-rich protein BstNI subfamily 4 |
|
| chr22_-_50523760 Show fit | 3.18 |
ENST00000395876.2
|
megalencephalic leukoencephalopathy with subcortical cysts 1 |
|
| chr4_+_36283213 Show fit | 3.05 |
ENST00000357504.3
|
death domain containing 1 |
|
| chr20_-_52612468 Show fit | 2.98 |
ENST00000422805.1
|
breast carcinoma amplified sequence 1 |
|
| chr19_+_55105085 Show fit | 2.92 |
ENST00000251372.3
ENST00000453777.1 |
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX13_SOX12
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 31.3 | GO:0002283 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 0.5 | 11.3 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
| 0.1 | 10.8 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 9.5 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.1 | 5.4 | GO:0042100 | B cell proliferation(GO:0042100) |
| 0.3 | 4.9 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.0 | 4.7 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.3 | 4.1 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.4 | 4.0 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.1 | 4.0 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 14.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 11.9 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 6.9 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.1 | 6.3 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 6.2 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 5.5 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 4.1 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.2 | 3.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 3.1 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 9.9 | GO:0008565 | protein transporter activity(GO:0008565) |
| 1.2 | 7.1 | GO:0023024 | MHC class I protein complex binding(GO:0023024) |
| 0.2 | 5.7 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.2 | 5.1 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.4 | 5.0 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.0 | 4.8 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 4.3 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.6 | 3.4 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.2 | 3.4 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 5.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 4.4 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 3.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.6 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 2.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 2.7 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 2.6 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 2.3 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 2.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 8.5 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 5.6 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.1 | 4.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 3.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 3.0 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 2.8 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 2.6 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.2 | 2.4 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 2.2 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |