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Illumina Body Map 2: averaged replicates

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Results for SOX21

Z-value: 0.98

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Transcription factors associated with SOX21

Gene Symbol Gene ID Gene Info
SOX21
ENSG00000125285.4 SRY-box transcription factor 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX21hg19_v2_chr13_-_95364389_95364389-0.522.5e-03Click!

Activity profile of SOX21 motif

Sorted Z-values of SOX21 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_42381173 3.27 ENST00000221972.3
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr19_+_42381337 2.75 ENST00000597454.1
ENST00000444740.2
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr1_-_26394114 2.53 ENST00000374272.3
TRIM63
tripartite motif containing 63, E3 ubiquitin protein ligase
chr14_+_64565442 2.21 ENST00000553308.1
SYNE2
spectrin repeat containing, nuclear envelope 2
chr11_+_35201826 2.21 ENST00000531873.1
CD44
CD44 molecule (Indian blood group)
chr4_-_177190364 2.14 ENST00000296525.3
ASB5
ankyrin repeat and SOCS box containing 5
chrY_+_14813160 2.07 ENST00000338981.3
USP9Y
ubiquitin specific peptidase 9, Y-linked
chr22_+_23063100 1.88 ENST00000390309.2
IGLV3-19
immunoglobulin lambda variable 3-19
chr5_-_147286065 1.64 ENST00000318315.4
ENST00000515291.1
C5orf46
chromosome 5 open reading frame 46
chr14_-_107170409 1.59 ENST00000390633.2
IGHV1-69
immunoglobulin heavy variable 1-69
chr3_+_154741907 1.57 ENST00000492661.1
MME
membrane metallo-endopeptidase
chr8_-_66750978 1.48 ENST00000523253.1
PDE7A
phosphodiesterase 7A
chr7_-_86849836 1.38 ENST00000455575.1
TMEM243
transmembrane protein 243, mitochondrial
chr7_-_142149390 1.36 ENST00000390372.3
TRBV5-5
T cell receptor beta variable 5-5
chr1_-_151148492 1.30 ENST00000295314.4
TMOD4
tropomodulin 4 (muscle)
chr4_+_69313145 1.25 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr12_+_69742121 1.22 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
LYZ
lysozyme
chr1_+_158901329 1.17 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
PYHIN1
pyrin and HIN domain family, member 1
chr7_-_86849883 1.09 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr8_-_142377367 1.05 ENST00000377741.3
GPR20
G protein-coupled receptor 20
chr14_+_23000889 1.04 ENST00000390525.1
TRAJ12
T cell receptor alpha joining 12
chr2_+_217363559 1.04 ENST00000600880.1
ENST00000446558.1
RPL37A
ribosomal protein L37a
chrX_-_39186610 0.95 ENST00000429281.1
ENST00000448597.1
RP11-265P11.2
RP11-265P11.2
chr22_+_39353527 0.90 ENST00000249116.2
APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr1_+_152881014 0.89 ENST00000368764.3
ENST00000392667.2
IVL
involucrin
chr1_+_221051699 0.85 ENST00000366903.6
HLX
H2.0-like homeobox
chr12_-_89746173 0.83 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr19_-_54784937 0.83 ENST00000434421.1
ENST00000314446.5
ENST00000391749.4
LILRB2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
chr11_+_2482661 0.83 ENST00000335475.5
KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr1_+_2487631 0.81 ENST00000409119.1
TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chr12_-_89746264 0.74 ENST00000548755.1
DUSP6
dual specificity phosphatase 6
chr18_-_47018869 0.72 ENST00000583036.1
ENST00000580261.1
RPL17
ribosomal protein L17
chr6_+_31371337 0.70 ENST00000449934.2
ENST00000421350.1
MICA
MHC class I polypeptide-related sequence A
chr11_+_5775923 0.67 ENST00000317254.3
OR52N4
olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)
chr20_+_43343886 0.66 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr6_+_140175987 0.63 ENST00000414038.1
ENST00000431609.1
RP5-899B16.1
RP5-899B16.1
chr1_-_198990166 0.63 ENST00000427439.1
RP11-16L9.3
RP11-16L9.3
chr1_+_203764742 0.63 ENST00000432282.1
ENST00000453771.1
ENST00000367214.1
ENST00000367212.3
ENST00000332127.4
ZC3H11A
zinc finger CCCH-type containing 11A
chr6_-_112575838 0.62 ENST00000455073.1
LAMA4
laminin, alpha 4
chr18_-_47018897 0.58 ENST00000418495.1
RPL17
ribosomal protein L17
chr7_-_142111859 0.55 ENST00000390378.1
TRBV5-7
T cell receptor beta variable 5-7 (non-functional)
chr4_-_39034542 0.54 ENST00000344606.6
TMEM156
transmembrane protein 156
chr18_-_47018769 0.54 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
RPL17
ribosomal protein L17
chr9_-_14910990 0.51 ENST00000380881.4
ENST00000422223.2
FREM1
FRAS1 related extracellular matrix 1
chr6_+_42531798 0.51 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr7_+_120702819 0.49 ENST00000423795.1
CPED1
cadherin-like and PC-esterase domain containing 1
chr15_-_99859828 0.49 ENST00000600203.1
AC022819.2
Uncharacterized protein
chr12_+_20522179 0.48 ENST00000359062.3
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr14_-_95922526 0.48 ENST00000554873.1
SYNE3
spectrin repeat containing, nuclear envelope family member 3
chr5_-_55529115 0.45 ENST00000513241.2
ENST00000341048.4
ANKRD55
ankyrin repeat domain 55
chr11_+_5410607 0.44 ENST00000328611.3
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr4_-_103747011 0.43 ENST00000350435.7
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr11_+_59855724 0.43 ENST00000524868.1
MS4A2
membrane-spanning 4-domains, subfamily A, member 2
chr4_+_81951957 0.41 ENST00000282701.2
BMP3
bone morphogenetic protein 3
chr8_-_50466973 0.41 ENST00000520800.1
RP11-738G5.2
Uncharacterized protein
chr12_+_123011776 0.40 ENST00000450485.2
ENST00000333479.7
KNTC1
kinetochore associated 1
chr14_+_23005092 0.39 ENST00000390529.1
TRAJ8
T cell receptor alpha joining 8
chr10_-_17243579 0.39 ENST00000525762.1
ENST00000412821.3
ENST00000351358.4
ENST00000377766.5
ENST00000358282.7
ENST00000488990.1
ENST00000377799.3
TRDMT1
tRNA aspartic acid methyltransferase 1
chr3_+_141103634 0.38 ENST00000507722.1
ZBTB38
zinc finger and BTB domain containing 38
chr12_+_1099675 0.37 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr12_-_1058849 0.36 ENST00000358495.3
RAD52
RAD52 homolog (S. cerevisiae)
chr1_-_169455169 0.35 ENST00000367804.4
ENST00000236137.5
SLC19A2
solute carrier family 19 (thiamine transporter), member 2
chr4_-_103746924 0.34 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr12_-_10588539 0.34 ENST00000381902.2
ENST00000381901.1
ENST00000539033.1
KLRC2
NKG2-E
killer cell lectin-like receptor subfamily C, member 2
Uncharacterized protein
chr19_+_16308711 0.34 ENST00000429941.2
ENST00000444449.2
ENST00000589822.1
AP1M1
adaptor-related protein complex 1, mu 1 subunit
chr9_+_99690592 0.34 ENST00000354649.3
NUTM2G
NUT family member 2G
chr17_-_65235916 0.31 ENST00000579861.1
HELZ
helicase with zinc finger
chr16_-_15149828 0.31 ENST00000566419.1
ENST00000568320.1
NTAN1
N-terminal asparagine amidase
chr4_-_103746683 0.30 ENST00000504211.1
ENST00000508476.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr4_+_75174180 0.30 ENST00000413830.1
EPGN
epithelial mitogen
chr19_+_18682531 0.29 ENST00000596304.1
ENST00000430157.2
UBA52
ubiquitin A-52 residue ribosomal protein fusion product 1
chr4_+_75174204 0.28 ENST00000332112.4
ENST00000514968.1
ENST00000503098.1
ENST00000502358.1
ENST00000509145.1
ENST00000505212.1
EPGN
epithelial mitogen
chr14_+_92588281 0.27 ENST00000298875.4
ENST00000553427.1
CPSF2
cleavage and polyadenylation specific factor 2, 100kDa
chr21_+_30672433 0.27 ENST00000451655.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr3_+_37035263 0.27 ENST00000458205.2
ENST00000539477.1
MLH1
mutL homolog 1
chr12_+_55886147 0.26 ENST00000379662.1
ENST00000548615.1
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr3_-_186288097 0.26 ENST00000446782.1
TBCCD1
TBCC domain containing 1
chr6_-_52926539 0.25 ENST00000350082.5
ENST00000356971.3
ICK
intestinal cell (MAK-like) kinase
chr1_-_202776392 0.24 ENST00000235790.4
KDM5B
lysine (K)-specific demethylase 5B
chr5_-_179045199 0.23 ENST00000523921.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr19_+_16308659 0.23 ENST00000590263.1
ENST00000590756.1
ENST00000541844.1
AP1M1
adaptor-related protein complex 1, mu 1 subunit
chr7_-_37026108 0.22 ENST00000396045.3
ELMO1
engulfment and cell motility 1
chr12_-_1058685 0.21 ENST00000397230.2
ENST00000542785.1
ENST00000544742.1
ENST00000536177.1
ENST00000539046.1
ENST00000541619.1
RAD52
RAD52 homolog (S. cerevisiae)
chr3_+_37035289 0.21 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
MLH1
mutL homolog 1
chr1_+_152670815 0.21 ENST00000368779.1
LCE2A
late cornified envelope 2A
chr14_-_66471241 0.19 ENST00000554907.1
CTD-2014B16.3
Uncharacterized protein
chr8_-_19459993 0.19 ENST00000454498.2
ENST00000520003.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr3_+_37034823 0.19 ENST00000231790.2
ENST00000456676.2
MLH1
mutL homolog 1
chr13_-_45048386 0.19 ENST00000472477.1
TSC22D1
TSC22 domain family, member 1
chr15_-_80263506 0.18 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr14_-_92588246 0.18 ENST00000329559.3
NDUFB1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr17_-_8702667 0.18 ENST00000329805.4
MFSD6L
major facilitator superfamily domain containing 6-like
chr6_-_112575758 0.18 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4
laminin, alpha 4
chr14_+_60712463 0.17 ENST00000325642.3
ENST00000529574.1
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr12_-_7261772 0.17 ENST00000545280.1
ENST00000543933.1
ENST00000545337.1
ENST00000544702.1
ENST00000266542.4
C1RL
complement component 1, r subcomponent-like
chr19_-_21950332 0.17 ENST00000598026.1
ZNF100
zinc finger protein 100
chr14_-_92588013 0.17 ENST00000553514.1
ENST00000605997.1
NDUFB1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr3_-_141747439 0.16 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr5_-_95158375 0.15 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX
glutaredoxin (thioltransferase)
chr6_+_131958436 0.14 ENST00000357639.3
ENST00000543135.1
ENST00000427148.2
ENST00000358229.5
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr14_-_38028689 0.14 ENST00000553425.1
RP11-356O9.2
RP11-356O9.2
chr5_-_59668541 0.14 ENST00000514552.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_+_7196565 0.13 ENST00000429911.1
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr11_-_8285405 0.13 ENST00000335790.3
ENST00000534484.1
LMO1
LIM domain only 1 (rhombotin 1)
chrX_-_71792477 0.12 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
HDAC8
histone deacetylase 8
chr1_+_67632083 0.12 ENST00000347310.5
ENST00000371002.1
IL23R
interleukin 23 receptor
chr2_-_241195452 0.12 ENST00000457178.1
AC124861.1
AC124861.1
chr6_-_121655850 0.12 ENST00000422369.1
TBC1D32
TBC1 domain family, member 32
chr9_+_109685630 0.11 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr7_+_2394445 0.10 ENST00000360876.4
ENST00000413917.1
ENST00000397011.2
EIF3B
eukaryotic translation initiation factor 3, subunit B
chr3_-_141747459 0.10 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr6_+_151815143 0.10 ENST00000239374.7
ENST00000367290.5
CCDC170
coiled-coil domain containing 170
chr8_-_146078376 0.08 ENST00000533270.1
ENST00000305103.3
ENST00000402718.3
COMMD5
COMM domain containing 5
chr12_+_101673872 0.07 ENST00000261637.4
UTP20
UTP20, small subunit (SSU) processome component, homolog (yeast)
chr19_-_20048639 0.06 ENST00000595282.1
AC007204.1
Uncharacterized protein
chrX_-_153210107 0.06 ENST00000369997.3
ENST00000393700.3
ENST00000412763.1
RENBP
renin binding protein
chrX_+_52927576 0.06 ENST00000416841.2
FAM156B
family with sequence similarity 156, member B
chr2_+_102759199 0.05 ENST00000409288.1
ENST00000410023.1
IL1R1
interleukin 1 receptor, type I
chr1_+_199996733 0.04 ENST00000236914.3
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr5_+_175875349 0.03 ENST00000261942.6
FAF2
Fas associated factor family member 2
chr16_-_15982440 0.03 ENST00000575938.1
ENST00000573396.1
ENST00000573968.1
ENST00000575744.1
ENST00000573429.1
ENST00000255759.6
ENST00000575073.1
FOPNL
FGFR1OP N-terminal like
chr5_-_95158644 0.03 ENST00000237858.6
GLRX
glutaredoxin (thioltransferase)
chr19_-_7040190 0.01 ENST00000381394.4
MBD3L4
methyl-CpG binding domain protein 3-like 4
chr19_-_45737469 0.01 ENST00000413988.1
EXOC3L2
exocyst complex component 3-like 2
chrX_-_55208866 0.01 ENST00000545075.1
MTRNR2L10
MT-RNR2-like 10
chr14_+_50291993 0.01 ENST00000595378.1
AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chr12_+_55968199 0.01 ENST00000321688.1
OR2AP1
olfactory receptor, family 2, subfamily AP, member 1
chr6_-_112575912 0.01 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4
laminin, alpha 4
chr12_+_80750652 0.00 ENST00000550182.1
OTOGL
otogelin-like
chr7_+_6713376 0.00 ENST00000399484.3
ENST00000544825.1
ENST00000401847.1
AC073343.1
Uncharacterized protein

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.3 1.6 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 2.2 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.2 2.2 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 0.7 GO:0051311 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.2 0.9 GO:0018262 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.1 1.6 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 1.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.9 GO:0070383 DNA cytosine deamination(GO:0070383)
0.1 0.8 GO:0002774 Fc receptor mediated inhibitory signaling pathway(GO:0002774)
0.1 0.5 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.9 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 0.8 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.1 0.6 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.1 0.8 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1 0.7 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.1 1.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 0.3 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.1 0.5 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 0.2 GO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721)
0.1 0.3 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.2 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0046013 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.1 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 6.0 GO:0042100 B cell proliferation(GO:0042100)
0.0 0.3 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.1 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.0 1.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.6 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.3 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.5 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.6 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.1 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 0.2 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.1 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.0 0.6 GO:0043485 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.0 3.5 GO:0030449 regulation of complement activation(GO:0030449)
0.0 1.0 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.2 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.0 1.4 GO:0035666 TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.0 0.4 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.5 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 2.9 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.4 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.1 GO:0006051 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.0 0.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.0 GO:0019815 B cell receptor complex(GO:0019815)
0.3 2.2 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2 0.7 GO:0005715 late recombination nodule(GO:0005715)
0.1 0.4 GO:0032997 Fc receptor complex(GO:0032997) Fc-epsilon receptor I complex(GO:0032998)
0.1 0.4 GO:1990423 RZZ complex(GO:1990423)
0.1 2.7 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 2.5 GO:0031430 M band(GO:0031430)
0.0 3.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.6 GO:0000346 transcription export complex(GO:0000346)
0.0 0.1 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 1.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.8 GO:0005605 basal lamina(GO:0005605)
0.0 1.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.2 0.5 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.1 0.8 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.1 0.8 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
0.1 2.5 GO:0031432 titin binding(GO:0031432)
0.1 0.3 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 1.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.4 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.1 0.7 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.1 0.5 GO:0070728 leucine binding(GO:0070728)
0.1 1.2 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.2 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.1 0.3 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.1 0.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 2.1 GO:0070410 co-SMAD binding(GO:0070410)
0.1 2.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.4 GO:0019863 IgE binding(GO:0019863)
0.0 1.3 GO:0005523 tropomyosin binding(GO:0005523)
0.0 1.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.0 0.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.2 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.1 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 1.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.8 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 3.5 GO:0003823 antigen binding(GO:0003823)
0.0 0.2 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 3.2 GO:0003735 structural constituent of ribosome(GO:0003735)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 6.1 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.6 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.8 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 5.9 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.6 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 1.4 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.7 REACTOME MEIOSIS Genes involved in Meiosis
0.0 1.2 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 2.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.6 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 2.9 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 5.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation