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Illumina Body Map 2: averaged replicates
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Results for SOX3_SOX2
Z-value: 3.64
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Transcription factors associated with SOX3_SOX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX2 | hg19_v2_chr3_+_181429704_181429722 | 0.72 | 3.9e-06 | Click! |
| SOX3 | hg19_v2_chrX_-_139587225_139587234 | 0.68 | 1.7e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX3_SOX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 32.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.0 | 21.0 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 1.2 | 19.9 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 2.7 | 18.8 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.2 | 18.8 | GO:0021954 | central nervous system neuron development(GO:0021954) |
| 0.3 | 16.6 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.4 | 15.7 | GO:0001573 | ganglioside metabolic process(GO:0001573) |
| 0.5 | 14.1 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.6 | 13.9 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 1.1 | 12.6 | GO:0006657 | CDP-choline pathway(GO:0006657) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 41.7 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 38.6 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.2 | 35.7 | GO:0034705 | potassium channel complex(GO:0034705) |
| 2.4 | 33.8 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 28.2 | GO:0043005 | neuron projection(GO:0043005) |
| 0.4 | 24.4 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.2 | 20.8 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 1.8 | 19.6 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.2 | 19.5 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.2 | 19.5 | GO:0043195 | terminal bouton(GO:0043195) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 65.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 50.9 | GO:0015631 | tubulin binding(GO:0015631) |
| 2.6 | 49.1 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.2 | 26.0 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.7 | 21.4 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.2 | 21.4 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.1 | 20.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 17.9 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.4 | 17.2 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 1.1 | 15.8 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 21.7 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 20.0 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 16.9 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 15.1 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.2 | 12.9 | PID ATR PATHWAY | ATR signaling pathway |
| 0.3 | 11.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 8.1 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 7.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 6.7 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.1 | 4.0 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 30.1 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.4 | 15.8 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.3 | 12.9 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.3 | 11.3 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.2 | 11.2 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 11.1 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.4 | 10.2 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 9.7 | REACTOME G ALPHA1213 SIGNALLING EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.3 | 8.9 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.2 | 8.2 | REACTOME KINESINS | Genes involved in Kinesins |