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Illumina Body Map 2: averaged replicates
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Results for SOX6
Z-value: 2.02
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Transcription factors associated with SOX6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX6 | hg19_v2_chr11_-_16430399_16430440 | -0.40 | 2.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_-_52645231 Show fit | 5.79 |
ENST00000448484.1
|
breast carcinoma amplified sequence 1 |
|
| chr12_-_45270077 Show fit | 4.97 |
ENST00000551601.1
ENST00000549027.1 ENST00000452445.2 |
NEL-like 2 (chicken) |
|
| chr4_-_109090106 Show fit | 4.86 |
ENST00000379951.2
|
lymphoid enhancer-binding factor 1 |
|
| chr4_-_109089573 Show fit | 4.65 |
ENST00000265165.1
|
lymphoid enhancer-binding factor 1 |
|
| chr12_-_45269769 Show fit | 4.53 |
ENST00000548826.1
|
NEL-like 2 (chicken) |
|
| chr12_-_45270151 Show fit | 4.51 |
ENST00000429094.2
|
NEL-like 2 (chicken) |
|
| chr8_+_24151553 Show fit | 4.37 |
ENST00000265769.4
ENST00000540823.1 ENST00000397649.3 |
ADAM metallopeptidase domain 28 |
|
| chr11_+_36317830 Show fit | 4.25 |
ENST00000530639.1
|
proline rich 5 like |
|
| chr14_-_106725723 Show fit | 4.08 |
ENST00000390609.2
|
immunoglobulin heavy variable 3-23 |
|
| chr5_-_146435572 Show fit | 3.51 |
ENST00000394414.1
|
protein phosphatase 2, regulatory subunit B, beta |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.6 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.8 | 14.0 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.4 | 10.3 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 1.4 | 9.5 | GO:0061153 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
| 0.6 | 8.5 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.3 | 6.2 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.1 | 6.1 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
| 0.1 | 5.8 | GO:0031648 | protein destabilization(GO:0031648) |
| 0.3 | 4.9 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.0 | 4.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.7 | 9.5 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.0 | 9.4 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.2 | 9.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.2 | 6.2 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.4 | 5.8 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 4.2 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 4.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 3.9 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 3.9 | GO:0043197 | dendritic spine(GO:0043197) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 12.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 10.3 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.5 | 9.5 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.0 | 8.9 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.3 | 8.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 5.8 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.3 | 5.1 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 5.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 4.5 | GO:0003823 | antigen binding(GO:0003823) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 9.5 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 9.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 4.3 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 4.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.9 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 3.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 3.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 2.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 2.3 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 4.0 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 3.8 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 3.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 3.6 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 3.4 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 2.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 2.3 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 1.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 1.7 | REACTOME ACYL CHAIN REMODELLING OF PE | Genes involved in Acyl chain remodelling of PE |