ISMARA results: SP4

Project

Illumina Body Map 2: averaged replicates

Navigation

Downloads

Results for SP4_PML

Z-value: 3.31

Motif logo

Transcription factors associated with SP4_PML

Gene Symbol	Gene ID	Gene Info
SP4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000105866.9	Sp4 transcription factor
PML Ensembl NCBI GeneCards UniProt NextProt	ENSG00000140464.15	PML nuclear body scaffold

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PML	hg19_v2_chr15_+_74287035_74287117	-0.24	1.8e-01	Click!
SP4	hg19_v2_chr7_+_21467642_21467671	-0.04	8.2e-01	Click!

Activity profile of SP4_PML motif

Sorted Z-values of SP4_PML motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_-_62130474 Show fit	14.67	ENST00000217182.3	EEF1A2 Ensembl NCBI GeneCards UniProt NextProt Show fit	eukaryotic translation elongation factor 1 alpha 2
chr22_-_38851205 Show fit	10.71	ENST00000303592.3	KCNJ4 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium inwardly-rectifying channel, subfamily J, member 4
chr4_+_2061119 Show fit	9.21	ENST00000423729.2	NAT8L Ensembl NCBI GeneCards UniProt NextProt Show fit	N-acetyltransferase 8-like (GCN5-related, putative)
chr2_-_241759622 Show fit	8.71	ENST00000320389.7 ENST00000498729.2	KIF1A Ensembl NCBI GeneCards UniProt NextProt Show fit	kinesin family member 1A
chr7_-_44365020 Show fit	8.13	ENST00000395747.2 ENST00000347193.4 ENST00000346990.4 ENST00000258682.6 ENST00000353625.4 ENST00000421607.1 ENST00000424197.1 ENST00000502837.2 ENST00000350811.3 ENST00000395749.2	CAMK2B Ensembl NCBI GeneCards UniProt NextProt Show fit	calcium/calmodulin-dependent protein kinase II beta
chr17_+_42836521 Show fit	7.74	ENST00000535346.1	ADAM11 Ensembl NCBI GeneCards UniProt NextProt Show fit	ADAM metallopeptidase domain 11
chr2_-_230579185 Show fit	7.52	ENST00000341772.4	DNER Ensembl NCBI GeneCards UniProt NextProt Show fit	delta/notch-like EGF repeat containing
chr11_-_17410869 Show fit	7.51	ENST00000528731.1	KCNJ11 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium inwardly-rectifying channel, subfamily J, member 11
chr5_-_693500 Show fit	7.39	ENST00000360578.5	TPPP Ensembl NCBI GeneCards UniProt NextProt Show fit	tubulin polymerization promoting protein
chr11_-_17410629 Show fit	7.31	ENST00000526912.1	KCNJ11 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium inwardly-rectifying channel, subfamily J, member 11

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SP4_PML

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.5	49.4	GO:0014733	regulation of skeletal muscle adaptation(GO:0014733)
0.8	38.4	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.3	31.0	GO:0071804	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
3.5	28.0	GO:1902613	regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.7	26.6	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
0.3	26.5	GO:0016079	synaptic vesicle exocytosis(GO:0016079)
1.1	25.3	GO:2001135	regulation of endocytic recycling(GO:2001135)
0.2	23.8	GO:0008277	regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0	23.6	GO:0016567	protein ubiquitination(GO:0016567)
0.6	23.4	GO:2000300	regulation of synaptic vesicle exocytosis(GO:2000300)

Showing 1 to 10 of 1,379 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	159.3	GO:0099572	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1	145.3	GO:0005739	mitochondrion(GO:0005739)
0.5	84.7	GO:0034705	potassium channel complex(GO:0034705)
0.1	77.7	GO:0000139	Golgi membrane(GO:0000139)
0.1	77.6	GO:0005759	mitochondrial matrix(GO:0005759)
0.3	75.3	GO:0098793	presynapse(GO:0098793)
0.5	60.3	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.7	46.0	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.2	45.3	GO:0031674	I band(GO:0031674)
0.1	39.0	GO:0030027	lamellipodium(GO:0030027)

Showing 1 to 10 of 451 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	108.0	GO:0003924	GTPase activity(GO:0003924)
0.1	92.5	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.2	61.5	GO:0008017	microtubule binding(GO:0008017)
0.6	38.3	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.7	37.7	GO:0030552	cAMP binding(GO:0030552)
0.6	36.9	GO:0017075	syntaxin-1 binding(GO:0017075)
0.2	36.9	GO:0044325	ion channel binding(GO:0044325)
0.1	35.4	GO:0003779	actin binding(GO:0003779)
0.5	34.6	GO:0030507	spectrin binding(GO:0030507)
0.2	32.1	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Showing 1 to 10 of 843 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	46.0	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.7	33.8	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.4	29.2	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.3	23.3	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.3	21.9	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.4	20.2	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.3	19.4	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.3	16.8	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	14.0	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.3	12.6	PID LPA4 PATHWAY	LPA4-mediated signaling events

Showing 1 to 10 of 100 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	91.1	REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES	Genes involved in Transmission across Chemical Synapses
1.2	60.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.5	50.1	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
1.3	43.8	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.7	42.8	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.1	37.4	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5	35.5	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.5	33.6	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.5	32.6	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.2	28.4	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides

Showing 1 to 10 of 169 entries

Results for SP4_PML

Z-value: 3.31

Motif logo

Transcription factors associated with SP4_PML

Activity-expression correlation:

Activity profile of SP4_PML motif

Sorted Z-values of SP4_PML motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SP4_PML

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: