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Illumina Body Map 2: averaged replicates
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Results for SPDEF
Z-value: 1.74
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Transcription factors associated with SPDEF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPDEF | hg19_v2_chr6_-_34524093_34524135 | -0.24 | 1.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPDEF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 11.3 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 9.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.3 | 9.0 | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity(GO:0045954) |
| 0.5 | 8.7 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.1 | 5.7 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) |
| 1.5 | 4.5 | GO:0060370 | susceptibility to T cell mediated cytotoxicity(GO:0060370) |
| 1.4 | 4.3 | GO:0019085 | early viral transcription(GO:0019085) |
| 0.7 | 4.2 | GO:0051490 | negative regulation of filopodium assembly(GO:0051490) |
| 0.6 | 3.9 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.6 | 3.7 | GO:0070945 | neutrophil mediated killing of gram-negative bacterium(GO:0070945) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 7.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 7.7 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 6.1 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.1 | 5.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.5 | 4.2 | GO:0071203 | WASH complex(GO:0071203) |
| 0.1 | 3.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.5 | 3.3 | GO:0010370 | perinucleolar chromocenter(GO:0010370) |
| 0.0 | 3.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.3 | 2.9 | GO:0033263 | CORVET complex(GO:0033263) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.5 | 11.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 8.7 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 7.7 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 5.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 4.2 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.1 | 3.9 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.4 | 3.7 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 0.0 | 3.7 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.4 | 3.6 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.0 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 11.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 4.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 3.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 3.0 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 2.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 2.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 2.5 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 2.4 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 2.3 | ST GA12 PATHWAY | G alpha 12 Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.0 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 9.7 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.0 | 6.6 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 6.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 5.1 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.1 | 3.6 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 3.6 | REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | Genes involved in TGF-beta receptor signaling activates SMADs |
| 0.1 | 3.3 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 3.1 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 2.8 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |