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Illumina Body Map 2: averaged replicates
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Results for SPI1
Z-value: 7.25
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Transcription factors associated with SPI1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPI1 | hg19_v2_chr11_-_47400062_47400077 | 0.84 | 1.3e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPI1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 160.8 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 1.3 | 141.3 | GO:0042100 | B cell proliferation(GO:0042100) |
| 18.0 | 90.1 | GO:2000471 | regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473) |
| 1.7 | 59.3 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.7 | 55.3 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 1.3 | 54.4 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.1 | 51.2 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 7.1 | 50.0 | GO:0002322 | B cell proliferation involved in immune response(GO:0002322) |
| 2.6 | 49.9 | GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291) |
| 2.3 | 49.7 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 312.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 174.2 | GO:0005829 | cytosol(GO:0005829) |
| 0.1 | 103.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 1.8 | 100.6 | GO:0001772 | immunological synapse(GO:0001772) |
| 7.6 | 99.2 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.2 | 86.6 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.2 | 72.4 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 1.8 | 63.5 | GO:0001891 | phagocytic cup(GO:0001891) |
| 4.3 | 47.6 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 2.0 | 46.6 | GO:0042101 | T cell receptor complex(GO:0042101) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 238.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 2.5 | 98.0 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.6 | 92.0 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 1.0 | 77.1 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 4.8 | 76.2 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 0.1 | 61.3 | GO:0003924 | GTPase activity(GO:0003924) |
| 2.3 | 55.7 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.5 | 55.0 | GO:1990782 | protein tyrosine kinase binding(GO:1990782) |
| 0.9 | 48.2 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 4.0 | 47.6 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 359.0 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.8 | 108.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 1.3 | 88.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.7 | 79.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 1.7 | 74.9 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 1.7 | 70.3 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.9 | 66.3 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.4 | 63.8 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.9 | 62.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.6 | 59.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 230.5 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 1.6 | 187.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.6 | 163.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 2.4 | 94.2 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 1.3 | 87.3 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 1.1 | 59.5 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 1.0 | 58.8 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.9 | 48.2 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.6 | 46.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.1 | 35.3 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |