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Illumina Body Map 2: averaged replicates
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Results for SPIB
Z-value: 6.88
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Transcription factors associated with SPIB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPIB | hg19_v2_chr19_+_50922187_50922215 | 0.70 | 8.3e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPIB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 93.1 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 2.0 | 56.3 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.5 | 54.8 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 0.3 | 53.7 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 6.8 | 47.6 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.1 | 44.9 | GO:0002283 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 6.0 | 42.3 | GO:0002322 | B cell proliferation involved in immune response(GO:0002322) |
| 1.9 | 41.9 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 8.0 | 40.1 | GO:0038043 | interleukin-5-mediated signaling pathway(GO:0038043) |
| 13.1 | 39.3 | GO:0045404 | positive regulation of interleukin-4 biosynthetic process(GO:0045404) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 321.0 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 262.8 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.4 | 105.7 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.4 | 83.0 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.2 | 63.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.3 | 59.5 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 59.1 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 6.3 | 43.8 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.2 | 43.8 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.3 | 36.2 | GO:0045335 | phagocytic vesicle(GO:0045335) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 150.6 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.2 | 92.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 79.4 | GO:0060089 | receptor activity(GO:0004872) molecular transducer activity(GO:0060089) |
| 0.7 | 70.4 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 2.0 | 56.3 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 1.0 | 52.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 51.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 12.6 | 50.5 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 1.3 | 50.2 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 4.0 | 47.6 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 141.3 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.8 | 66.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.9 | 65.5 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.9 | 62.7 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.2 | 60.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.7 | 57.7 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.4 | 53.7 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.8 | 46.5 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.7 | 45.3 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.4 | 37.7 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 106.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.3 | 86.5 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.6 | 73.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 2.3 | 56.3 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 1.9 | 55.1 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.6 | 42.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.7 | 41.7 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 1.0 | 40.1 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.5 | 39.9 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 1.6 | 38.8 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |