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Illumina Body Map 2: averaged replicates

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Results for SPIB

Z-value: 6.88

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Transcription factors associated with SPIB

Gene Symbol Gene ID Gene Info
ENSG00000269404.2 Spi-B transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPIBhg19_v2_chr19_+_50922187_509222150.708.3e-06Click!

Activity profile of SPIB motif

Sorted Z-values of SPIB motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_72709050 38.38 ENST00000583937.1
ENST00000301573.9
ENST00000326165.6
ENST00000469092.1
CD300 molecule-like family member f
chr1_-_160681593 28.61 ENST00000368045.3
ENST00000368046.3
CD48 molecule
chrX_-_47489244 23.03 ENST00000469388.1
ENST00000396992.3
ENST00000377005.2
complement factor properdin
chr22_+_37309662 20.08 ENST00000403662.3
ENST00000262825.5
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr3_-_151047327 19.40 ENST00000325602.5
purinergic receptor P2Y, G-protein coupled, 13
chr1_+_161676739 19.38 ENST00000236938.6
ENST00000367959.2
ENST00000546024.1
ENST00000540521.1
ENST00000367949.2
ENST00000350710.3
ENST00000540926.1
Fc receptor-like A
chr19_+_42381337 19.30 ENST00000597454.1
ENST00000444740.2
CD79a molecule, immunoglobulin-associated alpha
chr12_+_10124001 18.79 ENST00000396507.3
ENST00000304361.4
ENST00000434319.2
C-type lectin domain family 12, member A
chr17_-_72619783 18.76 ENST00000328630.3
CD300e molecule
chrX_+_78200829 18.47 ENST00000544091.1
purinergic receptor P2Y, G-protein coupled, 10
chrX_+_78200913 18.43 ENST00000171757.2
purinergic receptor P2Y, G-protein coupled, 10
chr5_-_66492562 18.38 ENST00000256447.4
CD180 molecule
chr12_+_10124110 17.86 ENST00000350667.4
C-type lectin domain family 12, member A
chr7_-_36764004 17.75 ENST00000431169.1
acyloxyacyl hydrolase (neutrophil)
chr17_-_72619869 17.67 ENST00000392619.1
ENST00000426295.2
CD300e molecule
chr1_+_209941827 17.58 ENST00000367023.1
TRAF3 interacting protein 3
chr7_+_74188309 17.57 ENST00000289473.4
ENST00000433458.1
neutrophil cytosolic factor 1
chr16_+_30194916 17.49 ENST00000570045.1
ENST00000565497.1
ENST00000570244.1
coronin, actin binding protein, 1A
chr9_-_71161505 17.43 ENST00000446290.1
RP11-274B18.2
chr12_+_8276433 17.33 ENST00000345999.3
ENST00000352620.3
ENST00000360500.3
C-type lectin domain family 4, member A
chr6_-_159466136 16.90 ENST00000367066.3
ENST00000326965.6
T-cell activation RhoGTPase activating protein
chr7_-_36764142 16.86 ENST00000258749.5
ENST00000535891.1
acyloxyacyl hydrolase (neutrophil)
chr12_-_55378470 16.67 ENST00000524668.1
ENST00000533607.1
thymocyte expressed, positive selection associated 1
chr12_-_55378452 16.46 ENST00000449076.1
thymocyte expressed, positive selection associated 1
chr5_+_169064245 16.34 ENST00000256935.8
dedicator of cytokinesis 2
chr1_+_161677034 16.04 ENST00000349527.4
ENST00000309691.6
ENST00000294796.4
ENST00000367953.3
ENST00000367950.1
Fc receptor-like A
chr7_-_36764062 15.90 ENST00000435386.1
acyloxyacyl hydrolase (neutrophil)
chr6_-_159466042 15.61 ENST00000338313.5
T-cell activation RhoGTPase activating protein
chr5_+_57787254 15.48 ENST00000502276.1
ENST00000396776.2
ENST00000511930.1
GRB2-binding adaptor protein, transmembrane
chr19_-_54850417 15.24 ENST00000291759.4
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
chr1_+_112016414 15.23 ENST00000343534.5
ENST00000369718.3
chromosome 1 open reading frame 162
chr1_-_160616804 15.01 ENST00000538290.1
signaling lymphocytic activation molecule family member 1
chr7_+_50344289 14.80 ENST00000413698.1
ENST00000359197.5
ENST00000331340.3
ENST00000357364.4
ENST00000343574.5
ENST00000349824.4
ENST00000346667.4
ENST00000440768.2
IKAROS family zinc finger 1 (Ikaros)
chr17_-_8868991 14.73 ENST00000447110.1
phosphoinositide-3-kinase, regulatory subunit 5
chr6_-_24936170 14.72 ENST00000538035.1
family with sequence similarity 65, member B
chr7_+_139528952 14.54 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
thromboxane A synthase 1 (platelet)
chr10_+_49917751 14.50 ENST00000325239.5
ENST00000413659.2
WDFY family member 4
chr17_+_72667239 14.30 ENST00000402449.4
RAB37, member RAS oncogene family
chr12_+_8276224 14.17 ENST00000229332.5
C-type lectin domain family 4, member A
chr17_-_43487780 14.12 ENST00000532038.1
ENST00000528677.1
Rho GTPase activating protein 27
chr12_-_15114492 14.10 ENST00000541546.1
Rho GDP dissociation inhibitor (GDI) beta
chr3_+_121774202 13.96 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86 molecule
chr1_+_161676983 13.92 ENST00000367957.2
Fc receptor-like A
chr5_+_54398463 13.80 ENST00000274306.6
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr17_-_5138099 13.70 ENST00000571800.1
ENST00000574081.1
ENST00000399600.4
ENST00000574297.1
SLP adaptor and CSK interacting membrane protein
chr16_-_50715239 13.63 ENST00000330943.4
ENST00000300590.3
sorting nexin 20
chrX_-_77582980 13.61 ENST00000373304.3
cysteinyl leukotriene receptor 1
chr9_-_35618364 13.52 ENST00000378431.1
ENST00000378430.3
ENST00000259633.4
CD72 molecule
chr6_+_391739 13.44 ENST00000380956.4
interferon regulatory factor 4
chr6_-_133079022 13.32 ENST00000525289.1
ENST00000326499.6
vanin 2
chr1_+_26644441 13.32 ENST00000374213.2
CD52 molecule
chr7_+_139529040 13.32 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
thromboxane A synthase 1 (platelet)
chr1_-_31230650 13.24 ENST00000294507.3
lysosomal protein transmembrane 5
chr19_+_16254488 13.19 ENST00000588246.1
ENST00000593031.1
hematopoietic SH2 domain containing
chr14_+_88471468 13.18 ENST00000267549.3
G protein-coupled receptor 65
chr22_+_37318082 13.07 ENST00000406230.1
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr2_+_68592305 13.02 ENST00000234313.7
pleckstrin
chr19_-_3786253 12.98 ENST00000585778.1
megakaryocyte-associated tyrosine kinase
chr6_+_31554779 12.63 ENST00000376090.2
leukocyte specific transcript 1
chr9_+_215158 12.42 ENST00000479404.1
dedicator of cytokinesis 8
chr9_+_214842 12.34 ENST00000453981.1
ENST00000432829.2
dedicator of cytokinesis 8
chr19_-_3786354 12.28 ENST00000395040.2
ENST00000310132.6
megakaryocyte-associated tyrosine kinase
chr7_+_139529085 12.09 ENST00000539806.1
thromboxane A synthase 1 (platelet)
chr6_-_41254403 12.05 ENST00000589614.1
ENST00000334475.6
ENST00000591620.1
ENST00000244709.4
triggering receptor expressed on myeloid cells 1
chr12_-_9885888 11.95 ENST00000327839.3
C-type lectin-like 1
chr3_+_121796697 11.94 ENST00000482356.1
ENST00000393627.2
CD86 molecule
chr12_-_15114191 11.94 ENST00000541380.1
Rho GDP dissociation inhibitor (GDI) beta
chr17_-_29641104 11.81 ENST00000577894.1
ENST00000330927.4
ecotropic viral integration site 2B
chr11_-_58980342 11.77 ENST00000361050.3
macrophage expressed 1
chr17_-_29641084 11.75 ENST00000544462.1
ecotropic viral integration site 2B
chr17_-_39093672 11.70 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
keratin 23 (histone deacetylase inducible)
chr19_+_6772710 11.58 ENST00000304076.2
ENST00000602142.1
ENST00000596764.1
vav 1 guanine nucleotide exchange factor
chr20_-_62710832 11.46 ENST00000395042.1
regulator of G-protein signaling 19
chr3_+_46395219 11.42 ENST00000445132.2
ENST00000292301.4
chemokine (C-C motif) receptor 2
chr13_+_108922228 11.42 ENST00000542136.1
tumor necrosis factor (ligand) superfamily, member 13b
chr5_+_35856951 11.32 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
interleukin 7 receptor
chr1_+_161475208 11.31 ENST00000367972.4
ENST00000271450.6
Fc fragment of IgG, low affinity IIa, receptor (CD32)
chr14_+_22217447 11.30 ENST00000390427.3
T cell receptor alpha variable 5
chr16_+_57576584 11.22 ENST00000340339.4
G protein-coupled receptor 114
chr8_-_131028782 11.20 ENST00000519020.1
family with sequence similarity 49, member B
chr12_+_54891495 10.90 ENST00000293373.6
NCK-associated protein 1-like
chr12_-_15114658 10.84 ENST00000542276.1
Rho GDP dissociation inhibitor (GDI) beta
chr6_+_36973406 10.84 ENST00000274963.8
FYVE, RhoGEF and PH domain containing 2
chr16_+_3096638 10.79 ENST00000336577.4
matrix metallopeptidase 25
chr22_-_37640277 10.78 ENST00000401529.3
ENST00000249071.6
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr20_-_62711259 10.76 ENST00000332298.5
regulator of G-protein signaling 19
chr12_-_15114603 10.72 ENST00000228945.4
Rho GDP dissociation inhibitor (GDI) beta
chr19_-_54746600 10.69 ENST00000245621.5
ENST00000270464.5
ENST00000419410.2
ENST00000391735.3
ENST00000396365.2
ENST00000440558.2
ENST00000407860.2
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
chrX_-_30595959 10.62 ENST00000378962.3
chromosome X open reading frame 21
chr13_+_31309645 10.61 ENST00000380490.3
arachidonate 5-lipoxygenase-activating protein
chr19_+_48828788 10.41 ENST00000594198.1
ENST00000597279.1
ENST00000593437.1
epithelial membrane protein 3
chr7_+_150211918 10.40 ENST00000313543.4
GTPase, IMAP family member 7
chr7_-_115799942 10.36 ENST00000484212.1
transcription factor EC
chr11_+_65408273 10.24 ENST00000394227.3
signal-induced proliferation-associated 1
chr12_+_7060508 10.21 ENST00000541698.1
ENST00000542462.1
protein tyrosine phosphatase, non-receptor type 6
chr4_+_68424434 10.14 ENST00000265404.2
ENST00000396225.1
signal transducing adaptor family member 1
chr12_+_8276495 10.12 ENST00000546339.1
C-type lectin domain family 4, member A
chr5_+_118668846 10.07 ENST00000513374.1
tumor necrosis factor, alpha-induced protein 8
chr2_+_113885138 10.01 ENST00000409930.3
interleukin 1 receptor antagonist
chr22_-_37640456 9.89 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr3_+_32433363 9.88 ENST00000465248.1
CKLF-like MARVEL transmembrane domain containing 7
chr12_-_9885702 9.84 ENST00000542530.1
C-type lectin-like 1
chr3_+_46283863 9.74 ENST00000545097.1
ENST00000541018.1
chemokine (C-C motif) receptor 3
chr3_+_46395579 9.73 ENST00000421659.1
chemokine (C-C motif) receptor 2
chr10_+_26727333 9.72 ENST00000356785.4
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr1_+_117544366 9.58 ENST00000256652.4
ENST00000369470.1
CD101 molecule
chr11_-_64512273 9.53 ENST00000377497.3
ENST00000377487.1
ENST00000430645.1
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr12_+_7060414 9.52 ENST00000538715.1
protein tyrosine phosphatase, non-receptor type 6
chr6_+_31582961 9.49 ENST00000376059.3
ENST00000337917.7
allograft inflammatory factor 1
chr19_+_7413835 9.43 ENST00000576789.1
CTB-133G6.1
chr11_-_3859089 9.38 ENST00000396979.1
ras homolog family member G
chr21_-_46340807 9.34 ENST00000397846.3
ENST00000524251.1
ENST00000522688.1
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr13_+_108921977 9.33 ENST00000430559.1
ENST00000375887.4
tumor necrosis factor (ligand) superfamily, member 13b
chr19_+_48828582 9.31 ENST00000270221.6
ENST00000596315.1
epithelial membrane protein 3
chr17_-_33885117 9.30 ENST00000415846.3
schlafen family member 14
chr15_+_77287426 9.26 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
proline-serine-threonine phosphatase interacting protein 1
chr19_-_54804173 9.20 ENST00000391744.3
ENST00000251390.3
leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
chr1_+_40840320 9.16 ENST00000372708.1
small ArfGAP2
chr11_-_64512803 9.15 ENST00000377489.1
ENST00000354024.3
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr19_+_50919056 9.10 ENST00000599632.1
CTD-2545M3.6
chr10_-_98480243 9.01 ENST00000339364.5
phosphoinositide-3-kinase adaptor protein 1
chr20_+_30640004 8.96 ENST00000520553.1
ENST00000518730.1
ENST00000375852.2
hemopoietic cell kinase
chr17_-_18950310 8.96 ENST00000573099.1
GRB2-related adaptor protein
chr17_-_73389854 8.95 ENST00000578961.1
ENST00000392564.1
ENST00000582582.1
growth factor receptor-bound protein 2
chr9_+_93564039 8.95 ENST00000375754.4
ENST00000375751.4
spleen tyrosine kinase
chr12_+_7060432 8.93 ENST00000318974.9
ENST00000456013.1
protein tyrosine phosphatase, non-receptor type 6
chr19_+_35940486 8.93 ENST00000246549.2
free fatty acid receptor 2
chr11_-_47400062 8.89 ENST00000533030.1
spleen focus forming virus (SFFV) proviral integration oncogene
chr14_-_23288930 8.86 ENST00000554517.1
ENST00000285850.7
ENST00000397529.2
ENST00000555702.1
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr19_-_52035044 8.80 ENST00000359982.4
ENST00000436458.1
ENST00000425629.3
ENST00000391797.3
ENST00000343300.4
sialic acid binding Ig-like lectin 6
chr1_+_159272111 8.76 ENST00000368114.1
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr11_+_60145967 8.76 ENST00000534016.1
membrane-spanning 4-domains, subfamily A, member 7
chr19_-_13213954 8.71 ENST00000590974.1
lymphoblastic leukemia derived sequence 1
chr19_-_10446449 8.68 ENST00000592439.1
intercellular adhesion molecule 3
chr17_-_73389737 8.68 ENST00000392563.1
growth factor receptor-bound protein 2
chr11_-_47399942 8.67 ENST00000227163.4
spleen focus forming virus (SFFV) proviral integration oncogene
chr21_-_32716556 8.64 ENST00000455508.1
T-cell lymphoma invasion and metastasis 1
chr9_+_93564191 8.63 ENST00000375747.1
spleen tyrosine kinase
chr16_-_50715196 8.55 ENST00000423026.2
sorting nexin 20
chr19_+_49838653 8.54 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37 molecule
chr11_-_64512469 8.53 ENST00000377485.1
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr21_-_46340884 8.48 ENST00000302347.5
ENST00000517819.1
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_+_143886877 8.47 ENST00000295095.6
Rho GTPase activating protein 15
chr5_-_39270725 8.47 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYN binding protein
chr6_+_31553901 8.35 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
leukocyte specific transcript 1
chr19_-_13213662 8.32 ENST00000264824.4
lymphoblastic leukemia derived sequence 1
chr2_-_145188137 8.29 ENST00000440875.1
zinc finger E-box binding homeobox 2
chr2_+_233924548 8.29 ENST00000422935.1
inositol polyphosphate-5-phosphatase, 145kDa
chr1_+_149754227 8.27 ENST00000444948.1
ENST00000369168.4
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr6_+_31553978 8.26 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
leukocyte specific transcript 1
chr19_+_35939154 8.25 ENST00000599180.2
free fatty acid receptor 2
chr9_-_130541017 8.25 ENST00000314830.8
SH2 domain containing 3C
chr6_+_31554612 8.25 ENST00000211921.7
leukocyte specific transcript 1
chr2_+_113931513 8.16 ENST00000245796.6
ENST00000441564.3
pleckstrin and Sec7 domain containing 4
chr20_-_35274548 8.14 ENST00000262866.4
Src-like-adaptor 2
chr11_-_47400032 8.13 ENST00000533968.1
spleen focus forming virus (SFFV) proviral integration oncogene
chr16_+_31213206 8.12 ENST00000561916.2
chromosome 16 open reading frame 98
chr1_+_15736359 8.07 ENST00000375980.4
EF-hand domain family, member D2
chr12_+_25205666 8.04 ENST00000547044.1
lymphoid-restricted membrane protein
chr6_+_31554826 8.04 ENST00000376089.2
ENST00000396112.2
leukocyte specific transcript 1
chr11_-_47400078 8.01 ENST00000378538.3
spleen focus forming virus (SFFV) proviral integration oncogene
chr1_+_151129103 8.01 ENST00000368910.3
tumor necrosis factor, alpha-induced protein 8-like 2
chr15_+_77287715 8.01 ENST00000559161.1
proline-serine-threonine phosphatase interacting protein 1
chr2_-_242089677 7.96 ENST00000405260.1
PAS domain containing serine/threonine kinase
chr17_-_43487741 7.95 ENST00000455881.1
Rho GTPase activating protein 27
chr8_-_101734308 7.86 ENST00000519004.1
ENST00000519363.1
ENST00000520142.1
poly(A) binding protein, cytoplasmic 1
chr10_+_129785536 7.82 ENST00000419012.2
protein tyrosine phosphatase, receptor type, E
chr22_-_37880543 7.78 ENST00000442496.1
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr6_+_31554456 7.78 ENST00000339530.4
leukocyte specific transcript 1
chr1_-_120935894 7.66 ENST00000369383.4
ENST00000369384.4
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr16_+_12059050 7.63 ENST00000396495.3
tumor necrosis factor receptor superfamily, member 17
chr21_-_46340770 7.53 ENST00000397854.3
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr3_+_46283916 7.44 ENST00000395940.2
chemokine (C-C motif) receptor 3
chr12_+_25205628 7.43 ENST00000554942.1
lymphoid-restricted membrane protein
chr6_+_31554636 7.41 ENST00000433492.1
leukocyte specific transcript 1
chr11_+_60145948 7.33 ENST00000300184.3
ENST00000358246.1
membrane-spanning 4-domains, subfamily A, member 7
chr17_+_8869157 7.19 ENST00000585297.1
CTB-41I6.1
chr5_-_156536126 7.15 ENST00000522593.1
hepatitis A virus cellular receptor 2
chr1_+_167599532 7.14 ENST00000537350.1
RCSD domain containing 1
chr10_+_129785574 7.11 ENST00000430713.2
ENST00000471218.1
protein tyrosine phosphatase, receptor type, E
chr6_-_154677900 6.98 ENST00000265198.4
ENST00000520261.1
interaction protein for cytohesin exchange factors 1
chr15_+_91427642 6.97 ENST00000328850.3
ENST00000414248.2
feline sarcoma oncogene
chr3_-_3151664 6.92 ENST00000256452.3
ENST00000311981.8
ENST00000430514.2
ENST00000456302.1
interleukin 5 receptor, alpha
chr9_+_93589734 6.92 ENST00000375746.1
spleen tyrosine kinase
chr8_-_101734170 6.89 ENST00000522387.1
ENST00000518196.1
poly(A) binding protein, cytoplasmic 1
chr14_-_98444369 6.86 ENST00000554822.1
chromosome 14 open reading frame 64
chr20_+_62711482 6.84 ENST00000336866.2
ENST00000355631.4
opiate receptor-like 1
chr14_-_98444438 6.82 ENST00000512901.2
chromosome 14 open reading frame 64
chr14_-_23588816 6.80 ENST00000206513.5
CCAAT/enhancer binding protein (C/EBP), epsilon
chr1_+_206643787 6.79 ENST00000367120.3
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr6_+_130339710 6.66 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
l(3)mbt-like 3 (Drosophila)
chr11_+_64107663 6.65 ENST00000356786.5
coiled-coil domain containing 88B
chr7_+_106505912 6.63 ENST00000359195.3
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr17_+_19030782 6.63 ENST00000344415.4
ENST00000577213.1
GRB2-related adaptor protein-like
chr11_+_60145997 6.61 ENST00000530614.1
ENST00000530027.1
ENST00000530234.2
ENST00000528215.1
ENST00000531787.1
membrane-spanning 4-domains, subfamily A, member 7
membrane-spanning 4-domains, subfamily A, member 14
chr12_+_15699286 6.58 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
protein tyrosine phosphatase, receptor type, O
chr2_-_231084659 6.53 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110 nuclear body protein
chr14_+_105391147 6.52 ENST00000540372.1
ENST00000392593.4
phospholipase D family, member 4
chr2_-_231084617 6.49 ENST00000409815.2
SP110 nuclear body protein
chr15_+_91427691 6.48 ENST00000559355.1
ENST00000394302.1
feline sarcoma oncogene

Network of associatons between targets according to the STRING database.

First level regulatory network of SPIB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
13.1 39.3 GO:0045404 positive regulation of interleukin-4 biosynthetic process(GO:0045404)
12.8 38.4 GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034125) regulation of interleukin-4-mediated signaling pathway(GO:1902214)
10.6 21.2 GO:1902567 negative regulation of eosinophil activation(GO:1902567)
10.5 31.4 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
10.1 10.1 GO:1903973 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
8.3 33.3 GO:0045399 positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401)
8.3 24.8 GO:0061485 memory T cell proliferation(GO:0061485)
8.0 40.1 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
6.8 47.6 GO:0071461 cellular response to redox state(GO:0071461)
6.7 33.7 GO:0044027 hypermethylation of CpG island(GO:0044027)
6.0 42.3 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
5.7 17.2 GO:0002232 leukocyte chemotaxis involved in inflammatory response(GO:0002232)
4.9 9.9 GO:0002337 B-1a B cell differentiation(GO:0002337)
4.8 28.7 GO:0033277 abortive mitotic cell cycle(GO:0033277)
4.7 33.1 GO:0010387 COP9 signalosome assembly(GO:0010387)
4.1 20.7 GO:0002636 positive regulation of germinal center formation(GO:0002636) B cell costimulation(GO:0031296)
4.1 12.2 GO:0002434 immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) negative regulation of dendritic cell antigen processing and presentation(GO:0002605) regulation of cytotoxic T cell degranulation(GO:0043317) negative regulation of cytotoxic T cell degranulation(GO:0043318) regulation of immune complex clearance by monocytes and macrophages(GO:0090264)
4.0 19.9 GO:0045659 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
3.6 10.9 GO:0045588 positive regulation of gamma-delta T cell differentiation(GO:0045588)
3.6 7.1 GO:0032672 regulation of interleukin-3 production(GO:0032672)
3.5 17.5 GO:0032796 uropod organization(GO:0032796)
3.5 17.3 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
3.0 9.0 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
2.4 21.6 GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
2.3 15.9 GO:0035709 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
2.2 13.5 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
2.2 17.7 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
2.2 6.6 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
2.2 26.3 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
2.2 12.9 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
2.0 10.2 GO:0042631 cellular response to water deprivation(GO:0042631)
2.0 6.1 GO:1901076 positive regulation of engulfment of apoptotic cell(GO:1901076)
2.0 56.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
2.0 12.1 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
2.0 5.9 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
1.9 13.6 GO:0061737 leukotriene signaling pathway(GO:0061737)
1.9 7.7 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
1.9 41.9 GO:0019371 cyclooxygenase pathway(GO:0019371)
1.9 20.7 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
1.8 3.6 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
1.8 23.5 GO:0016554 cytidine to uridine editing(GO:0016554)
1.8 9.0 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
1.8 5.4 GO:0045083 negative regulation of interleukin-12 biosynthetic process(GO:0045083)
1.8 23.0 GO:0036066 protein O-linked fucosylation(GO:0036066)
1.7 6.8 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
1.6 13.0 GO:0033625 positive regulation of integrin activation(GO:0033625)
1.6 11.0 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
1.5 17.6 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
1.4 9.5 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
1.3 9.0 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
1.3 25.4 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
1.3 10.0 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
1.2 4.7 GO:1990637 response to prolactin(GO:1990637)
1.1 4.3 GO:1903028 positive regulation of opsonization(GO:1903028)
1.1 17.0 GO:0001955 blood vessel maturation(GO:0001955)
1.1 10.6 GO:2001300 lipoxin metabolic process(GO:2001300)
1.1 4.2 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
1.0 14.5 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
1.0 6.2 GO:0021993 initiation of neural tube closure(GO:0021993)
1.0 5.1 GO:0052056 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
1.0 4.0 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
1.0 19.9 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
1.0 8.0 GO:0070091 glucagon secretion(GO:0070091) regulation of glucagon secretion(GO:0070092)
0.9 11.3 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.9 8.3 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.9 8.9 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.9 7.7 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.8 21.1 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.8 21.9 GO:0015671 oxygen transport(GO:0015671)
0.8 10.8 GO:0060022 hard palate development(GO:0060022)
0.8 2.4 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.8 6.1 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.8 19.7 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.8 5.3 GO:0070383 DNA cytosine deamination(GO:0070383)
0.7 9.7 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.7 13.3 GO:0015939 pantothenate metabolic process(GO:0015939)
0.7 8.1 GO:0071287 cellular response to manganese ion(GO:0071287)
0.7 21.3 GO:0032060 bleb assembly(GO:0032060)
0.7 3.5 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.7 2.8 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.6 5.8 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.6 11.4 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.6 13.1 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.6 4.3 GO:0071486 cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.6 2.4 GO:0032700 negative regulation of interleukin-17 production(GO:0032700)
0.6 4.8 GO:0061198 fungiform papilla formation(GO:0061198)
0.6 4.6 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.6 22.2 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.5 54.8 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.5 2.0 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.5 7.8 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.5 4.4 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.5 6.6 GO:0001562 response to protozoan(GO:0001562) defense response to protozoan(GO:0042832)
0.5 18.4 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.4 2.2 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.4 6.7 GO:0043249 erythrocyte maturation(GO:0043249)
0.4 8.1 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.4 4.7 GO:0060613 fat pad development(GO:0060613)
0.4 6.1 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.4 13.3 GO:0045730 respiratory burst(GO:0045730)
0.4 2.0 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
0.4 2.0 GO:1903615 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.4 13.2 GO:0010447 response to acidic pH(GO:0010447)
0.4 11.6 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.4 2.6 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.4 3.6 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.3 5.5 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.3 19.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.3 3.7 GO:0032264 IMP salvage(GO:0032264)
0.3 7.1 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.3 19.3 GO:0042100 B cell proliferation(GO:0042100)
0.3 14.7 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.3 35.6 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.3 2.2 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.3 25.2 GO:0006968 cellular defense response(GO:0006968)
0.3 5.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.3 1.4 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.3 3.7 GO:0035973 aggrephagy(GO:0035973)
0.3 3.0 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.3 8.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.3 4.7 GO:0007416 synapse assembly(GO:0007416) regulation of synapse assembly(GO:0051963)
0.3 9.4 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.3 14.9 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.3 53.7 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.3 2.5 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.2 1.5 GO:0001692 histamine metabolic process(GO:0001692)
0.2 3.1 GO:0010818 T cell chemotaxis(GO:0010818)
0.2 2.4 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.2 4.3 GO:0090168 Golgi reassembly(GO:0090168)
0.2 3.3 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.2 23.4 GO:0002819 regulation of adaptive immune response(GO:0002819)
0.2 2.5 GO:0018094 protein polyglycylation(GO:0018094)
0.2 3.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 4.9 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.2 0.8 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.2 8.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.2 23.4 GO:0071277 cellular response to calcium ion(GO:0071277)
0.2 2.2 GO:1903859 regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)
0.2 8.0 GO:0050868 negative regulation of T cell activation(GO:0050868)
0.2 9.2 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.2 0.8 GO:0070828 heterochromatin assembly(GO:0031507) heterochromatin organization(GO:0070828)
0.2 9.4 GO:0046039 GTP metabolic process(GO:0046039)
0.2 0.7 GO:0001767 establishment of lymphocyte polarity(GO:0001767)
0.2 6.8 GO:0030225 macrophage differentiation(GO:0030225)
0.2 0.7 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.2 0.9 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.2 11.9 GO:0043507 positive regulation of JUN kinase activity(GO:0043507)
0.2 8.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 1.2 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.2 0.7 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.2 3.4 GO:0006020 inositol metabolic process(GO:0006020)
0.1 12.6 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 1.1 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.1 1.1 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.4 GO:2000742 anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.1 1.6 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 1.7 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 19.7 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 14.5 GO:0030218 erythrocyte differentiation(GO:0030218)
0.1 18.4 GO:0006903 vesicle targeting(GO:0006903)
0.1 0.7 GO:0039019 pronephric nephron development(GO:0039019)
0.1 1.6 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.1 5.6 GO:0030855 epithelial cell differentiation(GO:0030855)
0.1 0.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 1.7 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.1 2.3 GO:0002115 store-operated calcium entry(GO:0002115)
0.1 0.5 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.1 9.6 GO:0015914 phospholipid transport(GO:0015914)
0.1 12.7 GO:0002250 adaptive immune response(GO:0002250)
0.1 3.2 GO:0007035 vacuolar acidification(GO:0007035)
0.1 1.2 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 1.3 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.1 0.8 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.4 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.1 5.6 GO:0035329 hippo signaling(GO:0035329)
0.1 14.9 GO:0007127 meiosis I(GO:0007127)
0.1 5.1 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 93.1 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 2.9 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 2.2 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 1.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 0.9 GO:0007172 signal complex assembly(GO:0007172)
0.1 11.7 GO:0070268 cornification(GO:0070268)
0.1 4.0 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.1 0.5 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.1 0.3 GO:0043686 co-translational protein modification(GO:0043686)
0.1 44.9 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.1 1.4 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.1 2.3 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 5.5 GO:0016266 O-glycan processing(GO:0016266)
0.1 2.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 10.4 GO:0034605 cellular response to heat(GO:0034605)
0.1 1.2 GO:0000729 DNA double-strand break processing(GO:0000729)
0.1 3.2 GO:0072348 sulfur compound transport(GO:0072348)
0.1 1.3 GO:1903204 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) negative regulation of oxidative stress-induced neuron death(GO:1903204)
0.1 2.6 GO:0046686 response to cadmium ion(GO:0046686)
0.1 0.5 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 3.1 GO:0006953 acute-phase response(GO:0006953)
0.1 1.0 GO:0090383 phagosome acidification(GO:0090383)
0.1 1.4 GO:0031663 lipopolysaccharide-mediated signaling pathway(GO:0031663)
0.1 6.6 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 5.4 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 2.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 2.2 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 3.8 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 1.8 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.7 GO:0014894 response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 5.8 GO:0034968 histone lysine methylation(GO:0034968)
0.0 0.6 GO:0001780 neutrophil homeostasis(GO:0001780)
0.0 5.1 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.0 GO:0031642 negative regulation of myelination(GO:0031642)
0.0 5.4 GO:0045047 protein targeting to ER(GO:0045047)
0.0 0.8 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 2.1 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 3.3 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.8 GO:0032201 DNA ligation(GO:0006266) nucleotide-excision repair, DNA gap filling(GO:0006297) telomere maintenance via semi-conservative replication(GO:0032201)
0.0 0.5 GO:0005513 detection of calcium ion(GO:0005513)
0.0 1.2 GO:1901998 toxin transport(GO:1901998)
0.0 35.2 GO:0006952 defense response(GO:0006952)
0.0 0.4 GO:0015886 heme transport(GO:0015886)
0.0 3.9 GO:0015992 proton transport(GO:0015992)
0.0 0.4 GO:0010990 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 2.1 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.0 1.2 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.3 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 1.0 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 1.4 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 2.0 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 8.3 GO:0016032 viral process(GO:0016032)
0.0 0.6 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.7 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.0 1.2 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.0 0.8 GO:0006611 protein export from nucleus(GO:0006611)
0.0 3.2 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 4.5 GO:0098656 anion transmembrane transport(GO:0098656)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
11.1 33.2 GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex(GO:0030526)
6.9 27.6 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
6.3 43.8 GO:0019815 B cell receptor complex(GO:0019815)
3.2 19.0 GO:0070436 Grb2-EGFR complex(GO:0070436)
3.2 25.4 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
2.9 25.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
2.2 28.7 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
1.8 17.6 GO:0032010 phagolysosome(GO:0032010)
1.1 31.0 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
1.1 3.2 GO:0032002 interleukin-28 receptor complex(GO:0032002)
1.0 33.1 GO:0001891 phagocytic cup(GO:0001891)
0.9 3.7 GO:0097635 extrinsic component of autophagosome membrane(GO:0097635)
0.8 11.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.7 0.7 GO:0071159 NF-kappaB complex(GO:0071159)
0.7 7.3 GO:0005955 calcineurin complex(GO:0005955)
0.7 13.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.7 9.7 GO:0042101 T cell receptor complex(GO:0042101)
0.7 4.7 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.7 8.1 GO:0072487 MSL complex(GO:0072487)
0.6 10.9 GO:0031209 SCAR complex(GO:0031209)
0.5 33.1 GO:0008180 COP9 signalosome(GO:0008180)
0.5 3.6 GO:0032009 early phagosome(GO:0032009)
0.5 29.7 GO:0001772 immunological synapse(GO:0001772)
0.5 5.4 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.5 15.9 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.5 4.7 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.5 1.9 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.4 83.0 GO:0035579 specific granule membrane(GO:0035579)
0.4 105.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4 5.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.4 3.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.3 2.2 GO:1990130 Iml1 complex(GO:1990130)
0.3 1.6 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.3 30.2 GO:0035580 specific granule lumen(GO:0035580)
0.3 36.2 GO:0045335 phagocytic vesicle(GO:0045335)
0.3 59.5 GO:0032587 ruffle membrane(GO:0032587)
0.3 4.5 GO:0046930 pore complex(GO:0046930)
0.3 2.7 GO:0042788 polysomal ribosome(GO:0042788)
0.3 22.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.2 5.5 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.2 43.8 GO:0031901 early endosome membrane(GO:0031901)
0.2 4.0 GO:0030897 HOPS complex(GO:0030897)
0.2 1.3 GO:0032044 DSIF complex(GO:0032044)
0.2 5.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.2 7.7 GO:0030686 90S preribosome(GO:0030686)
0.2 2.2 GO:0016600 flotillin complex(GO:0016600)
0.2 2.4 GO:0031906 late endosome lumen(GO:0031906)
0.2 4.6 GO:0071564 npBAF complex(GO:0071564)
0.2 63.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 3.3 GO:0030904 retromer complex(GO:0030904)
0.2 3.9 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 59.1 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 1.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.6 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.1 0.8 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 4.8 GO:0016580 Sin3 complex(GO:0016580)
0.1 11.0 GO:0005795 Golgi stack(GO:0005795)
0.1 2.5 GO:0000124 SAGA complex(GO:0000124) STAGA complex(GO:0030914)
0.1 32.2 GO:0030667 secretory granule membrane(GO:0030667)
0.1 16.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 10.4 GO:0005811 lipid particle(GO:0005811)
0.1 3.1 GO:0031932 TORC2 complex(GO:0031932)
0.1 262.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 5.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 3.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.7 GO:0030008 TRAPP complex(GO:0030008)
0.1 5.1 GO:0000786 nucleosome(GO:0000786)
0.1 1.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 4.8 GO:0016592 mediator complex(GO:0016592)
0.1 1.4 GO:0060091 kinocilium(GO:0060091)
0.1 0.5 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 5.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 12.1 GO:0016605 PML body(GO:0016605)
0.1 3.4 GO:0031519 PcG protein complex(GO:0031519)
0.1 1.0 GO:0097225 sperm midpiece(GO:0097225)
0.1 0.7 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 8.3 GO:0043235 receptor complex(GO:0043235)
0.1 30.7 GO:0000790 nuclear chromatin(GO:0000790)
0.1 0.8 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 1.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 3.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 321.0 GO:0016021 integral component of membrane(GO:0016021)
0.1 3.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 2.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 4.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.7 GO:0031527 filopodium membrane(GO:0031527) contractile ring(GO:0070938)
0.0 9.0 GO:0005882 intermediate filament(GO:0005882)
0.0 7.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 4.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 4.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.6 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.7 GO:0005776 autophagosome(GO:0005776)
0.0 2.2 GO:0098791 Golgi subcompartment(GO:0098791)
0.0 1.9 GO:0016235 aggresome(GO:0016235)
0.0 1.2 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 1.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 3.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 4.3 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 2.6 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 1.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.7 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 1.5 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 1.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 4.2 GO:0005925 focal adhesion(GO:0005925)
0.0 4.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.5 GO:0005902 microvillus(GO:0005902)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
12.8 38.4 GO:0005136 interleukin-4 receptor binding(GO:0005136)
12.6 50.5 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
10.0 39.9 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
8.0 40.1 GO:0004914 interleukin-5 receptor activity(GO:0004914)
4.2 21.2 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
4.0 47.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
3.5 10.6 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
3.3 10.0 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
3.2 28.7 GO:0019763 immunoglobulin receptor activity(GO:0019763)
2.8 11.3 GO:0004917 interleukin-7 receptor activity(GO:0004917)
2.6 13.1 GO:0036435 IkappaB kinase activity(GO:0008384) K48-linked polyubiquitin binding(GO:0036435)
2.6 33.7 GO:0051525 NFAT protein binding(GO:0051525)
2.5 19.9 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
2.3 13.6 GO:0004974 leukotriene receptor activity(GO:0004974)
2.3 15.9 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
2.2 13.3 GO:0017159 pantetheine hydrolase activity(GO:0017159)
2.2 15.3 GO:0016019 peptidoglycan receptor activity(GO:0016019)
2.1 25.4 GO:0030369 ICAM-3 receptor activity(GO:0030369)
2.0 56.3 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
1.8 10.9 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
1.7 10.4 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
1.6 19.6 GO:0019864 IgG binding(GO:0019864)
1.6 7.8 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
1.5 6.1 GO:0090556 apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
1.5 17.6 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
1.5 13.2 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
1.3 17.3 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
1.3 10.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
1.3 50.2 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
1.2 24.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
1.2 12.9 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
1.1 11.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
1.1 18.5 GO:0019957 C-C chemokine binding(GO:0019957)
1.1 4.3 GO:0045322 unmethylated CpG binding(GO:0045322)
1.0 16.3 GO:0042608 T cell receptor binding(GO:0042608)
1.0 6.1 GO:0039552 RIG-I binding(GO:0039552)
1.0 10.1 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
1.0 21.9 GO:0005344 oxygen transporter activity(GO:0005344)
1.0 17.6 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
1.0 52.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.9 17.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.9 14.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.8 29.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.8 27.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.8 7.8 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.8 4.6 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.8 4.5 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.7 9.0 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.7 5.5 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.7 6.8 GO:0004985 opioid receptor activity(GO:0004985)
0.7 70.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.7 17.6 GO:0008494 translation activator activity(GO:0008494)
0.6 11.4 GO:0004875 complement receptor activity(GO:0004875)
0.5 7.7 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.5 6.5 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.5 20.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.5 3.2 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.4 22.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.4 13.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.4 3.4 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.4 3.7 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.4 1.9 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.4 8.9 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.4 4.5 GO:0051434 BH3 domain binding(GO:0051434)
0.4 41.8 GO:0001618 virus receptor activity(GO:0001618)
0.3 2.4 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.3 5.8 GO:0005537 mannose binding(GO:0005537)
0.3 150.6 GO:0030246 carbohydrate binding(GO:0030246)
0.3 6.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.3 3.2 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.3 4.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.3 4.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.3 4.8 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.3 2.0 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.3 19.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.3 3.7 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.2 5.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.2 8.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 2.5 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.2 14.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 0.8 GO:0032184 SUMO polymer binding(GO:0032184)
0.2 18.7 GO:0016279 protein-lysine N-methyltransferase activity(GO:0016279)
0.2 6.4 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.2 10.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 92.3 GO:0005096 GTPase activator activity(GO:0005096)
0.2 5.1 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.2 4.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 5.9 GO:0032452 histone demethylase activity(GO:0032452)
0.2 2.4 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1 5.8 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 6.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.1 4.8 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 0.5 GO:0052591 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.1 0.9 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.1 4.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 4.7 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 10.9 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 0.5 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.1 2.2 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 3.7 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 51.5 GO:0003924 GTPase activity(GO:0003924)
0.1 7.9 GO:0019843 rRNA binding(GO:0019843)
0.1 3.0 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 11.4 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 5.3 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 2.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.4 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 1.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 8.1 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.9 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 2.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 2.0 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 2.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 9.5 GO:0097110 scaffold protein binding(GO:0097110)
0.1 44.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 1.2 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 3.1 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 2.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 2.0 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 3.3 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 1.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 7.4 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 4.3 GO:0043531 ADP binding(GO:0043531)
0.1 1.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 2.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 1.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 6.5 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 3.2 GO:0061650 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.1 1.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 3.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.5 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 1.3 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 3.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 4.7 GO:0008013 beta-catenin binding(GO:0008013)
0.0 79.4 GO:0060089 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.0 1.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0001032 RNA polymerase III type 3 promoter DNA binding(GO:0001032)
0.0 1.2 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.5 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 4.7 GO:0005179 hormone activity(GO:0005179)
0.0 1.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 3.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.5 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 0.7 GO:0017166 vinculin binding(GO:0017166)
0.0 3.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.9 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.4 GO:0015232 heme transporter activity(GO:0015232)
0.0 3.3 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.3 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 7.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 2.7 GO:0005525 GTP binding(GO:0005525)
0.0 1.9 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.0 0.6 GO:0030552 cAMP binding(GO:0030552)
0.0 0.3 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 1.4 GO:0005261 cation channel activity(GO:0005261)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 57.7 PID IL5 PATHWAY IL5-mediated signaling events
1.0 141.3 PID BCR 5PATHWAY BCR signaling pathway
0.9 62.7 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.9 26.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.9 65.5 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.8 46.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.8 66.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.7 45.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.7 25.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.5 16.6 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.5 14.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.4 37.7 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.4 20.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.4 53.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.4 4.7 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.3 14.9 PID IL6 7 PATHWAY IL6-mediated signaling events
0.3 10.0 PID IL1 PATHWAY IL1-mediated signaling events
0.3 9.1 PID IL3 PATHWAY IL3-mediated signaling events
0.2 13.6 PID ENDOTHELIN PATHWAY Endothelins
0.2 4.8 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 21.6 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 60.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 5.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 7.4 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 1.5 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 3.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 8.7 PID CMYB PATHWAY C-MYB transcription factor network
0.1 3.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 2.4 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 10.7 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.6 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.1 24.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 3.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.4 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.9 PID RHOA PATHWAY RhoA signaling pathway
0.0 1.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 1.4 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.6 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.3 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.8 PID TGFBR PATHWAY TGF-beta receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 56.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
1.9 28.7 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
1.9 55.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
1.6 38.8 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
1.3 86.5 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
1.0 40.1 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.9 10.1 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.9 7.8 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.8 29.1 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.8 17.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.8 11.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.7 15.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.7 13.6 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.7 41.7 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.6 2.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.6 73.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.6 42.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.5 39.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.4 5.8 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation