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Illumina Body Map 2: averaged replicates
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Results for SRF
Z-value: 4.86
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Transcription factors associated with SRF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SRF | hg19_v2_chr6_+_43140095_43140145 | 0.79 | 9.4e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SRF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.6 | 75.4 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 12.1 | 48.6 | GO:1901846 | positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846) |
| 2.6 | 44.5 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.3 | 35.7 | GO:0045445 | myoblast differentiation(GO:0045445) |
| 0.4 | 32.0 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 3.1 | 28.1 | GO:0055011 | atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014) |
| 2.6 | 26.2 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
| 0.2 | 24.6 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.6 | 24.3 | GO:0045663 | positive regulation of myoblast differentiation(GO:0045663) |
| 1.0 | 23.9 | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation(GO:1904706) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 64.7 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 3.7 | 48.6 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.7 | 39.0 | GO:0036379 | myofilament(GO:0036379) |
| 3.6 | 35.7 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.0 | 33.7 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.7 | 32.0 | GO:0031430 | M band(GO:0031430) |
| 6.1 | 30.5 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.7 | 23.5 | GO:0031143 | pseudopodium(GO:0031143) |
| 5.0 | 19.9 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
| 0.6 | 19.4 | GO:0046930 | pore complex(GO:0046930) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 50.6 | GO:0017022 | myosin binding(GO:0017022) |
| 1.4 | 48.7 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.2 | 47.0 | GO:0044325 | ion channel binding(GO:0044325) |
| 4.4 | 44.5 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 33.6 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.3 | 31.9 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.4 | 24.7 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.3 | 24.3 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 1.5 | 22.5 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.2 | 21.4 | GO:0008307 | structural constituent of muscle(GO:0008307) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 46.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.3 | 29.1 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.6 | 28.1 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.3 | 26.8 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 26.3 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 15.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 14.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 13.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.3 | 11.3 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.2 | 7.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 59.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 45.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.7 | 40.4 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
| 0.1 | 35.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 26.0 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 19.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 17.9 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.3 | 12.5 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.2 | 7.3 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.7 | 5.3 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |