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Illumina Body Map 2: averaged replicates
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Results for STAT1_STAT3_BCL6
Z-value: 2.23
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Transcription factors associated with STAT1_STAT3_BCL6
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000115415.14 | signal transducer and activator of transcription 1 | |
| ENSG00000168610.10 | signal transducer and activator of transcription 3 | |
| ENSG00000113916.13 | BCL6 transcription repressor |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT1 | hg19_v2_chr2_-_191878162_191878313 | -0.50 | 3.2e-03 | Click! |
| STAT3 | hg19_v2_chr17_-_40540586_40540600 | 0.32 | 7.4e-02 | Click! |
| BCL6 | hg19_v2_chr3_-_187455680_187455732 | -0.28 | 1.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of STAT1_STAT3_BCL6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.9 | 16.4 | GO:0017187 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
| 1.3 | 13.0 | GO:0045959 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) |
| 0.3 | 11.5 | GO:0006825 | copper ion transport(GO:0006825) |
| 2.9 | 8.6 | GO:0034226 | lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410) |
| 1.6 | 8.0 | GO:0060447 | bud outgrowth involved in lung branching(GO:0060447) |
| 0.8 | 6.6 | GO:2000860 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 1.9 | 5.8 | GO:0090265 | positive regulation of immune complex clearance by monocytes and macrophages(GO:0090265) |
| 0.4 | 5.2 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.2 | 5.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 50.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 14.7 | GO:0044217 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 0.4 | 11.4 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.4 | 7.9 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.5 | 7.5 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 7.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 6.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.9 | 5.8 | GO:0044299 | C-fiber(GO:0044299) |
| 0.4 | 5.6 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 5.6 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.9 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) |
| 0.1 | 18.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 10.2 | GO:0005518 | collagen binding(GO:0005518) |
| 0.8 | 9.5 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 1.8 | 9.0 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
| 0.4 | 8.6 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.8 | 8.0 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.2 | 5.3 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.2 | 5.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 4.7 | GO:0005044 | scavenger receptor activity(GO:0005044) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 19.6 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 13.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 10.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 9.2 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 9.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 9.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 8.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 4.7 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 4.2 | PID IL23 PATHWAY | IL23-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 22.6 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.6 | 17.8 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 14.4 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 12.5 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.4 | 9.6 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.1 | 9.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 8.8 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.2 | 5.8 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 5.6 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.1 | 5.4 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |