ISMARA results: STAT5A

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Illumina Body Map 2: averaged replicates

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Results for STAT5A

Z-value: 2.24

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Transcription factors associated with STAT5A

Gene Symbol	Gene ID	Gene Info
STAT5A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000126561.12	signal transducer and activator of transcription 5A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
STAT5A	hg19_v2_chr17_+_40440481_40440561	0.02	9.3e-01	Click!

Activity profile of STAT5A motif

Sorted Z-values of STAT5A motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_50649192 Show fit	5.72	ENST00000443053.2 ENST00000348721.3	CISH Ensembl NCBI GeneCards UniProt NextProt Show fit	cytokine inducible SH2-containing protein
chr1_-_36937075 Show fit	5.46	ENST00000464465.2	CSF3R Ensembl NCBI GeneCards UniProt NextProt Show fit	colony stimulating factor 3 receptor (granulocyte)
chr12_-_15082050 Show fit	5.14	ENST00000540097.1	ERP27 Ensembl NCBI GeneCards UniProt NextProt Show fit	endoplasmic reticulum protein 27
chr3_+_111260954 Show fit	5.05	ENST00000283285.5	CD96 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD96 molecule
chr4_+_155484103 Show fit	4.79	ENST00000302068.4	FGB Ensembl NCBI GeneCards UniProt NextProt Show fit	fibrinogen beta chain
chr4_-_155511887 Show fit	4.61	ENST00000302053.3 ENST00000403106.3	FGA Ensembl NCBI GeneCards UniProt NextProt Show fit	fibrinogen alpha chain
chr2_+_90198535 Show fit	4.57	ENST00000390276.2	IGKV1D-12 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1D-12
chr2_-_89292422 Show fit	4.50	ENST00000495489.1	IGKV1-8 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-8
chr17_-_33864772 Show fit	4.46	ENST00000361112.4	SLFN12L Ensembl NCBI GeneCards UniProt NextProt Show fit	schlafen family member 12-like
chr1_-_36948879 Show fit	4.35	ENST00000373106.1 ENST00000373104.1 ENST00000373103.1	CSF3R Ensembl NCBI GeneCards UniProt NextProt Show fit	colony stimulating factor 3 receptor (granulocyte)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT5A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	33.4	GO:0038094	Fc-gamma receptor signaling pathway(GO:0038094)
0.0	14.3	GO:0002446	neutrophil mediated immunity(GO:0002446)
0.9	13.0	GO:0043152	induction of bacterial agglutination(GO:0043152)
4.1	12.2	GO:0002728	negative regulation of natural killer cell cytokine production(GO:0002728)
0.1	11.5	GO:0045576	mast cell activation(GO:0045576)
0.1	11.2	GO:0002377	immunoglobulin production(GO:0002377)
0.1	10.7	GO:0031295	T cell costimulation(GO:0031295)
0.3	9.8	GO:0097186	amelogenesis(GO:0097186)
1.6	9.5	GO:0002729	positive regulation of natural killer cell cytokine production(GO:0002729)
0.7	8.6	GO:0016554	cytidine to uridine editing(GO:0016554)

Showing 1 to 10 of 451 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	28.5	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	22.5	GO:0005887	integral component of plasma membrane(GO:0005887)
0.1	20.8	GO:0035579	specific granule membrane(GO:0035579)
0.2	16.7	GO:0001772	immunological synapse(GO:0001772)
0.1	14.6	GO:0035578	azurophil granule lumen(GO:0035578)
1.0	13.6	GO:0005577	fibrinogen complex(GO:0005577)
1.0	9.2	GO:0097169	AIM2 inflammasome complex(GO:0097169)
0.0	8.0	GO:0001650	fibrillar center(GO:0001650)
0.0	8.0	GO:0016323	basolateral plasma membrane(GO:0016323)
0.4	7.8	GO:0042613	MHC class II protein complex(GO:0042613)

Showing 1 to 10 of 171 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	37.0	GO:0003823	antigen binding(GO:0003823)
0.7	13.0	GO:0019864	IgG binding(GO:0019864)
0.0	10.9	GO:0030674	protein binding, bridging(GO:0030674)
0.1	10.1	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
2.0	9.8	GO:0051916	granulocyte colony-stimulating factor binding(GO:0051916)
0.1	9.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	7.9	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	7.9	GO:0004860	protein kinase inhibitor activity(GO:0004860)
0.3	7.2	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.4	6.8	GO:0032395	MHC class II receptor activity(GO:0032395)

Showing 1 to 10 of 316 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	22.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.3	14.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	14.1	PID IL4 2PATHWAY	IL4-mediated signaling events
0.3	11.5	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1	10.2	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.2	9.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2	8.9	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.6	8.4	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.1	7.0	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	6.2	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway

Showing 1 to 10 of 67 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	51.8	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.6	12.8	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.2	9.7	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.3	9.2	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.5	8.5	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.1	8.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	8.1	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.2	7.9	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.2	7.9	REACTOME DEFENSINS	Genes involved in Defensins
0.2	7.7	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling

Showing 1 to 10 of 112 entries

Results for STAT5A

Z-value: 2.24

Motif logo

Transcription factors associated with STAT5A

Activity-expression correlation:

Activity profile of STAT5A motif

Sorted Z-values of STAT5A motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT5A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: