ISMARA results: STAT5B

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Illumina Body Map 2: averaged replicates

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Results for STAT5B

Z-value: 2.00

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Transcription factors associated with STAT5B

Gene Symbol	Gene ID	Gene Info
STAT5B Ensembl NCBI GeneCards UniProt NextProt	ENSG00000173757.5	signal transducer and activator of transcription 5B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
STAT5B	hg19_v2_chr17_-_40428359_40428462	-0.23	2.0e-01	Click!

Activity profile of STAT5B motif

Sorted Z-values of STAT5B motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_-_50523843 Show fit	2.85	ENST00000535444.1 ENST00000431262.2	MLC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	megalencephalic leukoencephalopathy with subcortical cysts 1
chr3_-_151047327 Show fit	2.84	ENST00000325602.5	P2RY13 Ensembl NCBI GeneCards UniProt NextProt Show fit	purinergic receptor P2Y, G-protein coupled, 13
chr22_-_50523807 Show fit	2.78	ENST00000442311.1 ENST00000538737.1	MLC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	megalencephalic leukoencephalopathy with subcortical cysts 1
chr22_-_50523688 Show fit	2.58	ENST00000450140.2	MLC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	megalencephalic leukoencephalopathy with subcortical cysts 1
chr17_-_26697304 Show fit	2.31	ENST00000536498.1	VTN Ensembl NCBI GeneCards UniProt NextProt Show fit	vitronectin
chr1_+_149754227 Show fit	2.16	ENST00000444948.1 ENST00000369168.4	FCGR1A Ensembl NCBI GeneCards UniProt NextProt Show fit	Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr22_-_50523760 Show fit	2.09	ENST00000395876.2	MLC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	megalencephalic leukoencephalopathy with subcortical cysts 1
chr22_-_37213554 Show fit	1.98	ENST00000443735.1	PVALB Ensembl NCBI GeneCards UniProt NextProt Show fit	parvalbumin
chr6_+_116782527 Show fit	1.95	ENST00000368606.3 ENST00000368605.1	FAM26F Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 26, member F
chr12_+_21207503 Show fit	1.94	ENST00000545916.1	SLCO1B7 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier organic anion transporter family, member 1B7 (non-functional)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT5B

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	10.3	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.4	5.5	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.5	3.8	GO:0010387	COP9 signalosome assembly(GO:0010387)
0.0	3.6	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.2	3.2	GO:0045329	carnitine biosynthetic process(GO:0045329)
0.1	3.2	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.1	2.8	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1	2.7	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.1	2.3	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.1	2.0	GO:0006108	malate metabolic process(GO:0006108)

Showing 1 to 10 of 70 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.5	GO:0005901	caveola(GO:0005901)
0.4	5.5	GO:0005577	fibrinogen complex(GO:0005577)
0.0	4.0	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1	3.9	GO:0008180	COP9 signalosome(GO:0008180)
0.6	2.3	GO:0071062	rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	2.0	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	2.0	GO:0043195	terminal bouton(GO:0043195)
0.0	1.8	GO:0001917	photoreceptor inner segment(GO:0001917)
0.0	1.6	GO:0005844	polysome(GO:0005844)
0.3	1.5	GO:1990031	pinceau fiber(GO:1990031)

Showing 1 to 10 of 35 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.6	GO:0008565	protein transporter activity(GO:0008565)
0.1	4.2	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	3.7	GO:0051087	chaperone binding(GO:0051087)
0.8	3.2	GO:0008336	gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1	2.8	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	2.7	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.5	2.0	GO:0047860	diiodophenylpyruvate reductase activity(GO:0047860)
0.2	1.8	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.1	1.8	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	1.8	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)

Showing 1 to 10 of 58 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.8	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	2.0	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	0.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms

Showing 1 to 3 of 3 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	24.0	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.3	5.5	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	4.6	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	3.6	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	2.9	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.1	2.5	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	2.5	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	2.0	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0	2.0	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	1.5	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules

Showing 1 to 10 of 23 entries

Results for STAT5B

Z-value: 2.00

Motif logo

Transcription factors associated with STAT5B

Activity-expression correlation:

Activity profile of STAT5B motif

Sorted Z-values of STAT5B motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT5B

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: