ISMARA results: TAL1

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Illumina Body Map 2: averaged replicates

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Results for TAL1

Z-value: 4.55

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Transcription factors associated with TAL1

Gene Symbol	Gene ID	Gene Info
TAL1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000162367.7	TAL bHLH transcription factor 1, erythroid differentiation factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TAL1	hg19_v2_chr1_-_47697387_47697457	0.69	1.1e-05	Click!

Activity profile of TAL1 motif

Sorted Z-values of TAL1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_106781017 Show fit	16.60	ENST00000390612.2	IGHV4-28 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy variable 4-28
chr2_-_89247338 Show fit	13.54	ENST00000496168.1	IGKV1-5 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-5
chr22_+_22681656 Show fit	13.39	ENST00000390291.2	IGLV1-50 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 1-50 (non-functional)
chr14_-_106539557 Show fit	13.27	ENST00000390599.2	IGHV1-8 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy variable 1-8
chr22_+_22730353 Show fit	12.91	ENST00000390296.2	IGLV5-45 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 5-45
chr14_-_106758101 Show fit	11.35	ENST00000390611.2	IGHV2-26 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy variable 2-26
chr22_+_23029188 Show fit	10.80	ENST00000390305.2	IGLV3-25 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 3-25
chr22_+_23040274 Show fit	10.64	ENST00000390306.2	IGLV2-23 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 2-23
chr14_-_106967788 Show fit	10.48	ENST00000390622.2	IGHV1-46 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy variable 1-46
chr14_-_106406090 Show fit	10.39	ENST00000390593.2	IGHV6-1 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy variable 6-1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TAL1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.9	507.6	GO:0006958	complement activation, classical pathway(GO:0006958)
0.9	196.4	GO:0002377	immunoglobulin production(GO:0002377)
0.4	131.7	GO:0002250	adaptive immune response(GO:0002250)
0.1	53.2	GO:0043312	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.5	34.7	GO:0006968	cellular defense response(GO:0006968)
0.3	33.5	GO:0071357	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
2.1	32.2	GO:2001199	negative regulation of dendritic cell differentiation(GO:2001199)
0.3	26.0	GO:0031295	T cell costimulation(GO:0031295)
5.3	21.0	GO:0035408	histone H3-T6 phosphorylation(GO:0035408)
1.0	20.9	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)

Showing 1 to 10 of 987 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.3	234.7	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.1	121.5	GO:0005615	extracellular space(GO:0005615)
0.5	105.6	GO:0072562	blood microparticle(GO:0072562)
0.3	96.0	GO:0009897	external side of plasma membrane(GO:0009897)
0.3	35.3	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
1.5	35.0	GO:0042101	T cell receptor complex(GO:0042101)
0.1	33.9	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
2.5	27.7	GO:0034687	integrin alphaL-beta2 complex(GO:0034687)
0.4	23.9	GO:0001772	immunological synapse(GO:0001772)
0.2	22.3	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)

Showing 1 to 10 of 311 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	450.8	GO:0003823	antigen binding(GO:0003823)
3.6	236.8	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.4	40.8	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.9	34.1	GO:0042287	MHC protein binding(GO:0042287)
0.2	31.1	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
2.3	27.7	GO:0030369	ICAM-3 receptor activity(GO:0030369)
0.5	26.8	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.6	24.0	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
5.3	21.0	GO:0035403	histone kinase activity (H3-T6 specific)(GO:0035403)
1.1	18.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)

Showing 1 to 10 of 605 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	72.0	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.7	50.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
1.1	34.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.7	25.7	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.3	22.9	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.2	20.6	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.4	19.3	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.3	18.4	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	18.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	15.5	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction

Showing 1 to 10 of 92 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	93.7	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.7	47.9	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.4	34.5	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
1.1	26.7	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.4	25.2	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
1.1	23.7	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.4	19.3	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.5	18.9	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	18.8	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.5	18.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling

Showing 1 to 10 of 156 entries

Results for TAL1

Z-value: 4.55

Motif logo

Transcription factors associated with TAL1

Activity-expression correlation:

Activity profile of TAL1 motif

Sorted Z-values of TAL1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TAL1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: