ISMARA results: TBP

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Illumina Body Map 2: averaged replicates

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Results for TBP

Z-value: 4.63

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Transcription factors associated with TBP

Gene Symbol	Gene ID	Gene Info
TBP Ensembl NCBI GeneCards UniProt NextProt	ENSG00000112592.8	TATA-box binding protein

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TBP	hg19_v2_chr6_+_170863421_170863484	-0.18	3.3e-01	Click!

Activity profile of TBP motif

Sorted Z-values of TBP motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_59043166 Show fit	11.92	ENST00000371225.2	TACSTD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	tumor-associated calcium signal transducer 2
chr16_+_82068830 Show fit	10.46	ENST00000199936.4	HSD17B2 Ensembl NCBI GeneCards UniProt NextProt Show fit	hydroxysteroid (17-beta) dehydrogenase 2
chr11_+_18287721 Show fit	10.28	ENST00000356524.4	SAA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serum amyloid A1
chr11_+_18287801 Show fit	10.25	ENST00000532858.1 ENST00000405158.2	SAA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serum amyloid A1
chr15_+_45722727 Show fit	10.01	ENST00000396650.2 ENST00000558435.1 ENST00000344300.3	C15orf48 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 15 open reading frame 48
chr17_-_34345002 Show fit	10.00	ENST00000293280.2	CCL23 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-C motif) ligand 23
chr1_+_159557607 Show fit	9.55	ENST00000255040.2	APCS Ensembl NCBI GeneCards UniProt NextProt Show fit	amyloid P component, serum
chr7_+_142829162 Show fit	9.48	ENST00000291009.3	PIP Ensembl NCBI GeneCards UniProt NextProt Show fit	prolactin-induced protein
chr19_+_46367518 Show fit	8.42	ENST00000302177.2	FOXA3 Ensembl NCBI GeneCards UniProt NextProt Show fit	forkhead box A3
chr17_-_34344991 Show fit	8.40	ENST00000591423.1	CCL23 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-C motif) ligand 23

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TBP

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	42.1	GO:0048247	lymphocyte chemotaxis(GO:0048247)
0.2	28.4	GO:0006958	complement activation, classical pathway(GO:0006958)
0.9	22.7	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.6	16.6	GO:0051798	positive regulation of hair follicle development(GO:0051798)
0.6	15.7	GO:0015669	gas transport(GO:0015669) oxygen transport(GO:0015671)
0.1	15.2	GO:0070268	cornification(GO:0070268)
0.3	12.2	GO:0071294	cellular response to zinc ion(GO:0071294)
2.4	12.0	GO:0015688	iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
1.5	11.9	GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.1	11.4	GO:0001895	retina homeostasis(GO:0001895)

Showing 1 to 10 of 241 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	138.0	GO:0005615	extracellular space(GO:0005615)
0.1	53.2	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.3	36.7	GO:0035580	specific granule lumen(GO:0035580)
0.9	25.5	GO:0071682	endocytic vesicle lumen(GO:0071682)
0.1	24.4	GO:0072562	blood microparticle(GO:0072562)
0.2	20.5	GO:0035578	azurophil granule lumen(GO:0035578)
0.2	18.7	GO:0045095	keratin filament(GO:0045095)
0.1	17.2	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
1.1	15.7	GO:0005833	hemoglobin complex(GO:0005833)
0.3	15.7	GO:0009925	basal plasma membrane(GO:0009925)

Showing 1 to 10 of 85 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	34.0	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.5	28.4	GO:0042056	chemoattractant activity(GO:0042056)
0.2	25.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
4.1	24.4	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.1	21.9	GO:0003735	structural constituent of ribosome(GO:0003735)
2.6	18.5	GO:0031726	CCR1 chemokine receptor binding(GO:0031726)
0.0	17.9	GO:0030246	carbohydrate binding(GO:0030246)
2.1	16.6	GO:0042289	MHC class II protein binding(GO:0042289)
0.8	15.7	GO:0005344	oxygen transporter activity(GO:0005344)
0.1	13.1	GO:0005044	scavenger receptor activity(GO:0005044)

Showing 1 to 10 of 161 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	30.4	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	28.5	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	28.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5	21.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.2	21.2	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	16.7	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.2	14.7	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.2	12.5	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2	12.3	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	12.0	NABA CORE MATRISOME	Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans

Showing 1 to 10 of 47 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	22.2	REACTOME AMYLOIDS	Genes involved in Amyloids
0.6	20.5	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.3	19.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.4	17.6	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.1	15.2	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.2	13.1	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.4	11.8	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.2	9.8	REACTOME DEFENSINS	Genes involved in Defensins
0.1	9.7	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.6	9.3	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins

Showing 1 to 10 of 57 entries

Results for TBP

Z-value: 4.63

Motif logo

Transcription factors associated with TBP

Activity-expression correlation:

Activity profile of TBP motif

Sorted Z-values of TBP motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TBP

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: