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Illumina Body Map 2: averaged replicates
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Results for TBX1
Z-value: 2.27
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Transcription factors associated with TBX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX1 | hg19_v2_chr22_+_19744226_19744226 | -0.14 | 4.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_123480194 Show fit | 4.47 |
ENST00000371139.4
|
SH2 domain containing 1A |
|
| chr6_-_31560729 Show fit | 4.41 |
ENST00000340027.5
ENST00000376073.4 ENST00000376072.3 |
natural cytotoxicity triggering receptor 3 |
|
| chr12_-_53594227 Show fit | 4.29 |
ENST00000550743.2
|
integrin, beta 7 |
|
| chr3_+_48264816 Show fit | 4.12 |
ENST00000296435.2
ENST00000576243.1 |
cathelicidin antimicrobial peptide |
|
| chr14_+_22689792 Show fit | 4.07 |
ENST00000390462.1
|
T cell receptor alpha variable 35 |
|
| chr11_-_64511789 Show fit | 3.84 |
ENST00000419843.1
ENST00000394430.1 |
RAS guanyl releasing protein 2 (calcium and DAG-regulated) |
|
| chr19_+_544034 Show fit | 3.75 |
ENST00000592501.1
ENST00000264553.3 |
granzyme M (lymphocyte met-ase 1) |
|
| chr20_-_1538319 Show fit | 3.49 |
ENST00000381621.1
|
signal-regulatory protein delta |
|
| chr19_-_51875894 Show fit | 3.42 |
ENST00000600427.1
ENST00000595217.1 ENST00000221978.5 |
natural killer cell group 7 sequence |
|
| chr2_+_7865923 Show fit | 3.39 |
ENST00000417930.1
|
AC092580.4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.2 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.1 | 13.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.4 | 12.1 | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity(GO:0045954) |
| 0.1 | 12.0 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 6.9 | GO:0042100 | B cell proliferation(GO:0042100) |
| 0.3 | 6.3 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.1 | 6.0 | GO:0002260 | lymphocyte homeostasis(GO:0002260) |
| 0.1 | 5.9 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.1 | 5.4 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.1 | 5.3 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.2 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 15.2 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.2 | 12.5 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 11.7 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 9.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 7.8 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.1 | 7.1 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.7 | 5.5 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
| 0.1 | 5.1 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.1 | 4.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.4 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 23.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.3 | 17.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 8.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.3 | 7.4 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.0 | 7.3 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.2 | 6.8 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.0 | 6.8 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 1.1 | 5.7 | GO:0051916 | granulocyte colony-stimulating factor binding(GO:0051916) |
| 0.5 | 5.6 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.3 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.2 | 13.4 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 10.9 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.2 | 9.7 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.1 | 8.0 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 7.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 6.4 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.2 | 5.9 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 4.7 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 4.7 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.0 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 14.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 11.5 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.3 | 8.0 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 7.9 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 6.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 5.6 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 5.2 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.2 | 5.1 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 5.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |